Toksikolojik Bir Perspektiften Sinsi Bir Tehlike: Pestisit Maruziyeti ve Nörodejeneratif Hastalıklar Arasındaki İlişki

Abstract

Artan sayıda araştırma, pestisit maruziyetini Alzheimer hastalığı, Parkinson hastalığı ve amiyotrofik lateral skleroz gibi nörodejeneratif hastalıkların etiyolojisinde önemli bir çevresel tetikleyici olarak göstermektedir. Pestisitler, nörotoksik potansiyelleri ile bilinir; kan-beyin bariyerini geçebilir, çevrede kalıcı olabilir ve oksidatif stres, mikroglial aktivasyon ve protein agregasyonu gibi mekanizmalar yoluyla hücresel hasara neden olabilirler. Bu etkiler yıllarca klinik belirti göstermeden sürebilir; bu durum “sessiz nörotoksisite” olarak adlandırılmaktadır. Bu derleme, pestisit kaynaklı nörodejenerasyonun toksikolojik temellerini ve bu hastalıkların artan küresel yükü ile ekonomik etkilerini epidemiolojik veriler ışığında incelemektedir. Ayrıca, yüksek riskli pestisit kullanımının kısıtlanması, güvenlik düzenlemelerinin iyileştirilmesi, biyopestisitlerin teşvik edilmesi ve erken tanı biyobelirteçlerinin geliştirilmesi gibi önleyici toksikolojik stratejilerin uzun vadeli nörolojik sonuçları azaltmak ve sürdürülebilir halk sağlığı politikalarını desteklemek için gerekliliği vurgulanmaktadır.

Keywords

• Pestisit maruziyeti
• nörotoksisite
• nörodejeneratif hastalıklar
• sessiz nörotoksisite

Project Number

no

Toxicological Perspective on a Stealth Threat: The Link Between Pesticide Exposure and Neurodegenerative Diseases

Abstract

Mounting research implicates pesticide exposure as a major environmental trigger in the etiology of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Pesticides, known for their neurotoxic potential, can cross the blood–brain barrier, persist in the environment, and trigger cellular damage through mechanisms including oxidative stress, microglial activation, and protein aggregation. Notably, these effects may remain clinically silent for years, a phenomenon termed “silent neurotoxicity.” This review explores the toxicological basis of pesticide-induced neurodegeneration, supported by epidemiological data showing a growing global burden and economic impact of these diseases. It further underscores the need for preventive toxicological strategies—such as restricting high-risk pesticide use, enhancing safety regulations, promoting biopesticides, and developing early diagnostic biomarkers—to mitigate long-term neurological outcomes and support sustainable public health policy.

Keywords

• Pesticide exposure
• neurotoxicity
• neurodegenerative diseases
• silent neurotoxicity

Supporting Institution

no

Project Number

no

Ethical Statement

Ethics committee approval is not required.

Thanks

no

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