Case Report

A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use

Volume: 1 Number: 2 July 17, 2019
Eurasian Journal of Toxicology Cover
Eurasian Journal of Toxicology
PDF Download
TR EN

A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use

Abstract

Serotonin syndrome is a life-threatening, undesirable drug reaction. It is a combination of symptoms caused by over activation at central and peripheral serotonin receptors secondary to high serotonin levels. Olanzapine, a second generation antipsychotic agent, is an antagonist of serotonin receptor. Despite the effect of serotonin antagonism, it is reported that olanzapine may paradoxically trigger serotonin syndrome. In this case report, we present a patient with SS due to chronic olanzapine use accompanied by bullous drug reaction.

Keywords

References

  1. 1- Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013; 13(4): 533-40.
  2. 2- Monte AA, Waksman JC. Chronic olanzapine, serotonin receptors, and subsequent serotonin toxicity. J Clin Psychopharmacol. 2010; 30(5): 628-9.
  3. 3- Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005; 352: 1112-20.
  4. 4- Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003; 96(9): 635-42.
  5. 5- McDaniel WW. Serotonin syndrome: early management with cyproheptadine. Ann Pharmacother. 2001; 35(7-8): 870-873.
  6. 6- Haslett CD, Kumar S. Can olanzapine be implicated in causing serotonin syndrome? Psychiatry Clin Neurosci. 2002; 56(5): 533-5.
  7. 7- Isbister GK, Downes F, Whyte IM. Olanzapine and serotonin toxicity. Psychiatry Clin Neurosci. 2003; 57: 244.

Details

Primary Language

English

Subjects

Emergency Medicine

Journal Section

Case Report

Authors

Publication Date

July 17, 2019

Submission Date

January 14, 2019

Acceptance Date

February 23, 2019

Published in Issue

Year 2019 Volume: 1 Number: 2

IZ

https://izlik.org/JA83KB26TZ

Cite

RIS / Bibtex
APA
Dağar, S., Emektar, E., Tandoğan, M., Çorbacıoğlu, Ş. K., Uzunosmanoğlu, H., & Çevik, Y. (2019). A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian Journal of Toxicology, 1(2), 65-68. https://izlik.org/JA83KB26TZ
AMA
1.Dağar S, Emektar E, Tandoğan M, Çorbacıoğlu ŞK, Uzunosmanoğlu H, Çevik Y. A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian J Tox. 2019;1(2):65-68. https://izlik.org/JA83KB26TZ
Chicago
Dağar, Seda, Emine Emektar, Meral Tandoğan, Şeref Kerem Çorbacıoğlu, Hüseyin Uzunosmanoğlu, and Yunsur Çevik. 2019. “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”. Eurasian Journal of Toxicology 1 (2): 65-68. https://izlik.org/JA83KB26TZ.
EndNote
Dağar S, Emektar E, Tandoğan M, Çorbacıoğlu ŞK, Uzunosmanoğlu H, Çevik Y (July 1, 2019) A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian Journal of Toxicology 1 2 65–68.
IEEE
[1]S. Dağar, E. Emektar, M. Tandoğan, Ş. K. Çorbacıoğlu, H. Uzunosmanoğlu, and Y. Çevik, “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”, Eurasian J Tox, vol. 1, no. 2, pp. 65–68, July 2019, [Online]. Available: https://izlik.org/JA83KB26TZ
ISNAD
Dağar, Seda - Emektar, Emine - Tandoğan, Meral - Çorbacıoğlu, Şeref Kerem - Uzunosmanoğlu, Hüseyin - Çevik, Yunsur. “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”. Eurasian Journal of Toxicology 1/2 (July 1, 2019): 65-68. https://izlik.org/JA83KB26TZ.
JAMA
1.Dağar S, Emektar E, Tandoğan M, Çorbacıoğlu ŞK, Uzunosmanoğlu H, Çevik Y. A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian J Tox. 2019;1:65–68.
MLA
Dağar, Seda, et al. “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”. Eurasian Journal of Toxicology, vol. 1, no. 2, July 2019, pp. 65-68, https://izlik.org/JA83KB26TZ.
Vancouver
1.Seda Dağar, Emine Emektar, Meral Tandoğan, Şeref Kerem Çorbacıoğlu, Hüseyin Uzunosmanoğlu, Yunsur Çevik. A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian J Tox [Internet]. 2019 Jul. 1;1(2):65-8. Available from: https://izlik.org/JA83KB26TZ