Evaluation of the Patients Admitted to Emergency Department with Paracetamol İntoxication

Abstract

Aim: We aimed to evaluate the demographical and clinical variations and treatment and complications of the patients admitted to emergency department (ED) with paracetamol intoxication.

Material and Method: This is a retrospective study. Patients who were diagnosed as paracetamol intoxication at the ED of Keçiören Health Research and Application Center Hospital included into the study. Patients with missed data, pregnant patients and patients with drug intoxications other than paracetamol were excluded. Statistical analysis was performed using the Statistical Package for the Social Sciences version 16.0.  P-value less than 0.05 was considered statistically significant.

Results:  Fifty-five patient included into the study. Mean age of the patients was 34±12 years and 63.6% of them were female. The amount of paracetamol ingested was 11.02±4.04 gr and fourth hour paracetamol level was 28.8 µg/dl (IQR 25-75: 12.5-41.7). There was a statistically significant weak correlation between the amount of paracetamol ingested and the blood paracetamol level of the patients(r=0,475 ve p=0,04). Liver function tests of the patients were elevated during the follow up and that was statistically significant (p<0.05).

Conclusion: According to the results despite of more than half of the patients ingested paracetamol at toxic doses, at most of them severity of intoxication was mild. Levels of the liver function tests of the patients could increase at paracetamol intoxication compared to baseline levels.

 

Keywords

• Paracetamol,intoxication,liver function tests

Acil Servise Parasetamol İntoksikasyonu Nedeniyle Başvuran Hastaların Değerlendirilmesi

Abstract

Amaç: Bu çalışmada, acil kliniğine parasetamol intoksikasyonu nedeniyle başvuran hastaların; demografik, klinik değişkenleri, tedavileri ve komplikasyonlarını değerlendirmeyi amaçladık.

Materyal ve Metot: Bu çalışma retrospektif bir çalışmadır. Keçiören Sağlık Araştırma ve Uygulama Merkezi Hastanesi acil kliniğinde parasetamol intoksikasyonu tanısı alan hastalar çalışmaya dahil edildi. Verileri eksik olanlar, gebeler, parasetamol dışı ilaçlarla zehirlenen hastalar çalışma dışı bırakıldı. Verilerin analizi SPSS 16 programında yapıldı. p<0.05 istatistiksel olarak anlamlı kabul edildi.

Bulgular: Çalışmaya 55 hasta dahil edildi.  Hastaların yaş ortalaması 34±12 yıl olup, %63,6’sı kadındı. Hastaların aldıkları parasetamol miktarı 11.02±4.04 gr ve dördüncü saat parasetamol düzeyleri 28.8 µg/dl (IQR 25-75: 12.5-41.7) olarak bulundu. Hastaların aldıkları parasetamol miktarı ile kan parasetamol düzeyi arasında istatistiksel anlamlı zayıf düzeyde korelasyon saptandı (r=0,475 ve p=0,04). Hastaların takip süresince bakılan karaciğer fonksiyon testlerinde artış saptandı ve bu fark istatistiksel olarak anlamlıydı (p<0.05).

Sonuç: Çalışma bulgularımıza göre hastalarımız yarıdan fazlası toksik doz parasetamol almış olmasına rağmen büyük bir kısmında zehirlenme şiddetinin hafif olduğu görülmüştür. Parasetamol zehirlenmelerinde hastaların karaciğer fonksiyon testlerinde başlangıç değerlerine göre artış olabilmektedir.

Keywords

• Parasetamol,zehirlenme,karaciğer fonksiyon testleri

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