2012-2019 Yılları Arasında Acil Servise Parasetamol İntoksikasyonu ile Başvuran Hastaların Retrospektif Analizi

Abstract

Amaç:  Bu çalışma üçüncü basamak bir acil servis kliniğine kendine zarar verme amacıyla parasetamol alan hastaların demografik, klinik, tedavi, yan etkiler, laboratuar verileri gibi bir takım değişkenlerin analizini yapmak amacıyla planlanmıştır.

Gereç ve Yöntem: Bu çalışma retrospektif bir çalışmadır. Çalışmamıza 14.01.2012 ile 04.05.2019 tarihleri arasında Atatürk Üniversitesi Araştırma Hastanesi acil servis polikliniğine suisid amacıyla parasetamol etken maddeli ilaç alan 18 yaş üstü hastalar dahil edildi. Veriler hasta dosyaları taranarak elde edildi. Kronik hastalığı olanlar, gebeler, genel durumu kötü olanlar, eksik verisi olanlar çalışma dışı bırakıldı.

Bulgular: Çalışmamıza 129 hasta dahil edildi. Hastaların 89’u (%69) kadın cinsiyetteydi. Hastaların yaş ortalaması 25,8 ± 8,6’ydı. Hastaların yaşları 18-69 arasında değişmekteydi. 43 hasta toksik dozda parasetamol almıştı. Hastaların aldıkları parasetamol miktarı ile kan parasetamol düzeyi arasında korelasyon vardı. Alınan parasetamol miktarı ile diğer kan parametreleri arasında anlamlı ilişki yoktu.

Tartışma: Çalışmamızda alınan parasetamol miktarı ile kan parasetamol düzeyi arasında korelasyon tespit edilmiştir. Ancak karaciğer fonksiyon testlerinde ve Uluslararası Düzeltme Oranı  (INR) değerinde istatistiksel olarak anlamlı bir farklılık gösterilememiştir. Bu konuda daha fazla prospektif çalışmaya ihtiyaç vardır.

Keywords

• Asetaminofen,intoksikasyon,karaciğer fonksiyon testleri,INR,parasetamol zehirlenmesi

Retrospective Analysis of Patients Presented With Parasetamol Intoxation to the Emergency Department Between 2012-2019

Abstract

Objective: This study was planned to analyze some variables such as demographic, clinical, treatment, side effects, laboratory data of patients taking paracetamol for self-harm in a tertiary emergency department.

Materials and Methods: This is a retrospective study. Patients over 18 years of age who received paracetamol active substance for suicidal purposes in the emergency department of Atatürk University Research Hospital between 14.01.2012 and 04.05.2019 were included in the study. Patients with chronic disease, pregnant women, patients with poor general condition and missing data were excluded from the study.

Results: 129 patients were included in the study. 89 (69%) of the patients were female. The mean age of the patients was 25.8 ± 8.6 years. The ages of the patients ranged from 18 to 69 years. Forty-three patients had received paracetamol in toxic doses. There was a correlation between the amount of paracetamol and blood paracetamol levels. There was no significant relationship between the amount of paracetamol and other blood parameters.

Conclusion: In our study, there was a correlation between the amount of paracetamol taken and blood paracetamol level. However, there was no statistically significant difference in liver function tests and International Normalized Ratio (INR) values. Further prospective studies are needed.

Keywords

• Acetaminophen,intoxication,paracetamol intoxication,INR,liver function tests

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