Tricyclic Antidepressant Drug in Toxication

Yıl 2024, Cilt: 6 Sayı: 2, 19 - 21, 31.08.2024

Sümeyye Tuğba Sarkı Cander

https://doi.org/10.51262/ejtox.1531689

Öz

Tricyclic antidepressant (TCA) poisoning is one of the conditions that can lead to serious clinical consequences and require urgent medical attention. The clinical presentation of TCA toxicity can range from severe cardiotoxicity to mild antimuscarinic symptoms and signs. The most severe toxicity is to the cardiovascular, central nervous and peripheral nervous system. Sodium bicarbonate therapy is highly effective in treating arrhythmias and improving metabolic acidosis, although there is no known antidote for treatment. This review aims to present current in formation about the pathophysiology, clinical findings, diagnostic and therapeutic methods and prognosis of TCA poisoning.

Anahtar Kelimeler

Tricyclic Antidepressant Drug, Toxication, EMERGENCY MEDİCİNE

Kaynakça

• Gareri P, De Fazio P, De Fazio S, Marigliano N, Ferreri Ibbadu G, De Sarro G. Adverse effects of atypical antipsychotics in the elderly: a review. Drugs Aging. 2006;23:937-56.
• Avau B, Borra V, Vanhove AC, Vandekerckhove P, De Paepe P, De Buck E. First aid interventions by laypeople for acute oral poisoning. Cochrane Database Syst Rev. 2018 Dec 19;12(12):CD013230.
• https://www.uptodate.com/contents/tricyclic-antidepressantpoisoning? search=epidemiology%20of%20tricyclic%20 antidepressant%20poisoning.
• İçme F. Kalp etkilenmesine sebep olan antikolinerjik ilaç zehirlenmelerinde sodyum bikarbonat tedavisinin etkinliğinin karşılaştırılması (Tıpta uzmanlık tezi). Adana, Çukurova Üniversitesi. 2006.
• https://www.uptodate.com/contents/tricyclic-antidepressantpoisoning.
• Liebelt, EL. Cyclic antidepressants. In Goldfrank’s Toxicology Emergencies. 8th ed. (Eds NE Flomenbaum, LR Goldfrank, RS Hoffman, MA Howland, NA Lewin, LS Nelson):1083-98. New York, McGraw-Hill, 2006.
• Benowitz, NL. Antidepressants, Tricyclic. Poisoning and drug overdose. 5th ed: USA, McGraw-Hill Inc, 2007;91-3.
• Muhammad M. Khalid; Muhammad Waseem. Tricyclic Antidepressant Toxicity. StatPearls Publishing; 2024.
• Chan C.Y., Waring W.S. Images in cardiovascular medicine: tricyclic cardiotoxicity treated with sodium bicarbonate. Circulation. 2007;115(5):e63–64.
• Thanacoody H.K., Thomas S.H. Tricyclic antidepressant poisoning: cardiovascular toxicity. Toxicol. Rev. 2005;24(3):205–14.
• ECG, lifeinthefastlane.com – ECG library
• Kalkan Ş. Antidepresanlarla zehirlenme. Türk Farmakoloji Derneği, 20. Ulusal Farmakoloji Kongresi, 3. Klinik Toksikoloji Sempozyumu, 4.Klinik Farmakoloji Sempozyumu Kongre Programı ve Bildiri Özet Kitabı. Antalya. 2009:28-35
• Kerr G.W., McGuffie A.C., Wilkie S. Tricyclic antidepressant overdose: a review. Emerg. Med. J.: EMJ. 2001;18(4):236–41.
• Zapalska-Pozarowska K., Szponar J., Tchorz M., Kostek H., Pozarowski W. [Severe tricyclic antidepressants poisoning?a case study] Przegl. Lek. 2012;69(8):621–3.
• Aslan Ş, Emet M, Çakır Z, Aköz A, Gür STA. Suicide attempts with amitriptyline in adults: A prospective, demographic, clinical study. Turk J Med Sci. 2011;41:243-9.
• Boehnert M.T., Lovejoy F.H., Jr. Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. N. Engl. J. Med. 1985;313(8):474–79.
• Cao D, Heard K, Foran M, Koyfman A. Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. J Emerg Med. 2015 Mar;48(3):387-97.
• Güloglu C, Orak M, Ustündag M, Altunci YA. Analysis of amitriptyline overdose in emergency medicine. Emerg Med J. 2011 Apr;28(4):296-9.