The metabolites of ellagitannin metabolism urolithins display various biological activities

Year 2019, Volume: 2 Issue: 2 , 102 - 110 , 30.12.2019

Jale Yuzugulen , Bahareh Noshadi , Karar Shukur Mustafa Fethi Sahin Hayrettin Ozan Gulcan

https://izlik.org/JA94RG84WJ

Abstract

Dietary consumption to various nuts, berries, and particularly
pomegranate is an important source of ellagitannins. These molecules are
particularly subject to gastrointestinal metabolism producing urolithins as their
metabolites. Urolithins (i.e., hydroxylated benzo[c]chromen-6-one analogues) have
a greater absorption than the ellagitannins thus; greater bioavailability is of
great significance. Therefore, the biological activities obtained through the use
of ellagitannin rich foods are mainly attributed tourolithins. These compounds
possess a good peripheral distribution. In addition, some of their further
metabolitescan penetrate to the central nervous system which, is of a topic of
interest for CNS related pathologies. This review has aimed to introduce the
structure and metabolism related formation of different urolithins concomitant
to their biological activities discovered so far in the literature.

Keywords

Urolithins , Ellagitannins , Metabolism , Cholinesterases , Antioxidant , Anticancer , Antimalarial , anti-inflammatory

Thanks

The authors declare no conflict of interest.

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