ORALLY DISINTEGRATING TABLETS: A SHORT REVIEW

Year 2018, Volume: 1 Issue: 1, 76 - 81, 01.06.2018

Dilek Emine Ozyılmaz Leyla Beba Pozharani Mustafa Alhadi Adama Emmanuella Ochanya

Abstract

The oral route is widely accepted and common method of drug delivery. Nowadays, with the rising the patient compliance and ease of drug administration, especially for pediatrics, new dosage forms are being introduced. When the ODT oral disintegrating tablets are placed on the tongue, with the help of saliva they disintegrate and then they are absorbed into the bloodstream from the oromucosal cavity without the need for water. These dosage forms have some advantages over the conventional oral dosage forms due to the fact that,amongst all other advantages, they bypass hepatic metabolism, which means that more of the drug is absorbed into the systemic circulation, leading to higher bioavailability and higher therapeutic efficacy. Novel techniques have been investigated to formulate ODT’s in order to achieve desired tablet characteristics to improve API compatibility and patient acceptance with this oral dosage form.

Keywords

Oral dosage forms, oral disintegrating tablet, hepatic metabolism, novel techniques.

References

• Abdelbary, G., Eouani, C., Prinderre, P., Joachim, J., Reynier, J. P., & Piccerelle, P. H. (2005).Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration.International journal of pharmaceutics, 292 (1), 29-41.
• Baber, N. (1994). International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (ICH).British journal of clinical pharmacology, 37(5), 401-404.
• Bhati, R., Nagrajan, R. K. (2012). A detailed review on oral mucosal drug delivery system.International Journal of Pharmaceutical Sciences and Research, 3(3), 659.
• Bi, Y. X., Sunada, H., Yonezawa, Y., & Danjo, K. (1999).Evaluation of rapidly disintegrating tablets prepared by a direct compression method.Drug development and Industrial pharmacy, 25(5), 571-581.
• Bi, Y., Sunada, H., Yonezawa, Y., Danjo, K., Otsuka, A., & IIDA, K. (1996).Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity.Chemical and pharmaceutical bulletin, 44(11), 2121-2127.
• Davtyan, L., Voronkina, A. (2016). International Journal of PharmTech Research. Desai, P. M., Liew, C. V., & Heng, P. W. S. (2016). Review of disintegrants and the disintegration phenomena. Journal of pharmaceutical sciences, 105(9), 2545-2555.
• Handa, U., Saroha, K., & Rana, R. (2016).World Journal of Pharmaceutical and Life Sciences WJPLS.drugs, 1, 2.
• Hannan, P. A., Khan, J. A., Khan, A., & Safiullah, S. (2016). Oral dispersible system: A new approach in drug delivery system. Indian journal of pharmaceutical sciences, 78(1), 2.
• Hooda, R., Tripathi, M., & Kapoor, K. (2012).A review on oral mucosal drug delivery system.The pharma innovation, 1(1).
• Hu, X., Li, Y., Zhang, E., Wang, X., Xing, M., Wang, Q., ...& Huang, H. (2013). Preparation and evaluation of orally disintegrating tablets containing taste-masked microcapsules of berberine hydrochloride.AAPS Pharm.SciTech, 14(1), 29-37.
• Klancke, J. (2003). Dissolution testing of orally disintegrating tablets.Dissolution technologies, 10(2), 6-9. Kraemer, J., Gajendran, J., Guillot, A., Schichtel, J., & Tuereli, A. (2012).Dissolution testing of orally disintegrating tablets.Journal of Pharmacy and Pharmacology, 64(7), 911-918.
• Manivannan, R. (2009). Oral disintegrating tablets: A future compaction. Drug Invention Today, 1(1), 61-65. Mathew, A. K. (2015). Oral local drug delivery: An overview. Pharm. Pharmacol Res, 3, 1-6.
• Mishra, D. N., Bindal, M., Singh, S. K., & Kumar, S. G. V. (2006). Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets. Chemical and pharmaceutical bulletin, 54(1), 99-102.
• Nagar, P., Singh, K., Chauhan, I., Verma, M., Yasir, M., Khan, A. and Gupta, N. (2011).Orally disintegrating tablets: formulation, preparation techniques and evaluation.
• Rao, K. V., and Venkatachalam, V. V. (2010).Recent Advances in Gastro-Retentive Drug Delivery Systems. Sastry, S. V., Nyshadham, J. R., and Fix, J. A. (2000).Recent technological advances in oral drug delivery–a review.Pharmaceutical science & technology today, 3(4), 138-145.
• Sharma, D. (2013). Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders.ISRN pharmaceutics, 2013.
• Sharma, D., Singh, G., Kumar, D., & Singh, M. (2015). Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate, cetirizine hydrochloride in combined pharmaceutical dosage form: A new era in novel drug delivery for pediatrics and geriatrics. Journal of drug delivery, 2015.
• Sotoyama, M., Uchida, S., Tanaka, S., Hakamata, A., Odagiri, K., Inui, N.and Namiki, N. (2017). Citric Acid Suppresses the Bitter Taste of Olopatadine Hydrochloride Orally Disintegrating Tablets. Biological and Pharmaceutical Bulletin, 40(4), 451-457.
• Thyssen, A., Remmerie, B., D'Hoore, P., Kushner, S., & Mannaert, E. (2007). Rapidly disintegrating risperidone in subjects with schizophrenia or schizoaffective disorder: a summary of ten phase I clinical trials assessing taste, tablet disintegration time, bioequivalence, and tolerability. Clinical therapeutics, 29 (2), 290-304.
• Velmurugan, S. and Vinushitha, S. (2010). Oral disintegrating tablets: An overview. International Journal of Chemical and Pharmaceutical Sciences, 1(2), 1-12. Zhang, Y., & Carlin, B. (2010).U.S. Patent Application No. 12/702,846.