Synthesis of 7-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)-3,4-dihydroquinolin-2(1H)-one and Screening Its Cholinesterase Inhibitor Properties

Year 2025, Volume: 8 Issue: 1, 8 - 13, 03.07.2025

Manijeh Dehnabi , Açelya Mavideniz , Tugba Ercetin , Hayrettin Ozan Gülcan

https://doi.org/10.54994/emujpharmsci.1697699

Abstract

Aripiprazole is a well-known atypical antipsychotic drug [i.e., 7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one]. The pharmacological effects of aripiprazole are primarily attributed to its partial agonist activity at dopamine and serotonin receptors, although the exact mechanism of action remains unclear. However, it is generally accepted that aripiprazole exerts its therapeutic effects by modulating dopaminergic and serotoninergic neurotransmission. This study aimed to synthesize a modified derivative of aripiprazole and to investigate the cholinesterase inhibitory potential of this compound. The cholinesterase inhibition potential of the synthesized compound was evaluated using the Ellman’s method. The inhibitory activities against various cholinesterases were determined. The results indicated that the scaffold employed might be used for further cholinesterase inhibitor molecule design.

Keywords

Alzheimer’s disease , Antioxidant activity , Aripiprazole , Cholinesterase inhibition , Modified Ellman’s method

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