Is the clinical significance of double-J stent colonization following ureteroscopic lithotripsy ignored?

Öz

Objective: To assess the significance of colonizing microorganisms in double-J stent (DJS) and determine the safest indwelling time of DJS that would cause no or less urinary tract infection (UTI) or colonization. Another objective was to examine the factors that influence DJS colonization.
Material And Methods: The data of patients that underwent ureteroscopic lithotripsy in our clinic from November 2017 till February 2020 were retrospectively reviewed and patients with DJS culture were included in the study. The patients were divided into two groups: DJS colonization positive (group 1) and DJS colonization negative (group 2).
Results: The colonization rate of 215 consecutive DJSs was 31.2%. Colonization increased with increasing age, especially in the 7th decade and later (p=0.013). The mean duration of DJS indwelling was 43.1±40.0 days in group 1 and 32.0 ± 15.6 days in group 2 (p=0.032). The colonization rates of DJS indwelling for 4 week or less, 4-6 weeks, and more than 6 weeks were 27.5%, 26.0% and 50.0%, respectively (p=0.017). DJS colonization positively correlated with development of UTI and urine culture positivity (kappa (κ) coefficient=0.100, κ=0.216, respectively, p<0,05). The multivariate regression analysis showed that the independent risk factors associated with UTI were urine culture positivity before stent removal (OR:29.487, p<0.001) and >6 weeks DJS indwelling time (OR:7.584, p=0.003).
Conclusion: Urine culture positivity and DJS indwelling longer than 6 weeks were the factors that could predict UTI in patients with DJS after ureteroscopic lithotripsy. In addition, high comorbidity score, UTI history and urine culture positivity were independent risk factors for DJS colonization.

Anahtar Kelimeler

• colonization
• double j stent
• ureteroscopy
• urine culture
• urinary tract infection
• urolithiasis.

Üreteroskopik litotripsi sonrası yerleştirilen double-J stentteki kolonizasyonun klinik önemi göz ardı edilir mi?

Öz

Amaç: Double-J stent (DJS) üzerinde mikroorganizmaların kolonize olmasının önemini değerlendirmek ve idrar yolu enfeksiyonuna (İYE) veya kolonizasyona neden olmayacak veya daha az olmasına neden olacak en güvenli DJS kalma süresini belirlemek. Diğer bir amaç ise DJS kolonizasyonunu etkileyen faktörleri incelemekti.
Gereç ve Yöntemler: Kliniğimizde Kasım 2017-Şubat 2020 tarihleri arasında üreteroskopik litotripsi uygulanan hastaların verileri geriye dönük olarak incelendi ve DJS kültürü olan hastalar çalışmaya dahil edildi. Hastalar DJS kolonizasyonu pozitif (grup 1) ve DJS kolonizasyonu negatif (grup 2) olmak üzere iki gruba ayrıldı.
Bulgular: Ardışık 215 DJS’nin kolonizasyon oranı %31,2 idi. Özellikle 7. dekat ve sonrasında belirgin olmakla birlikte kolonizasyon yaş ilerledikçe daha fazla görüldü (p=0,013). Ortalama DJS kalma süresi grup 1’de 43,1±40,0 gün ve grup 2’de 32,0±15,6 gündü (p=0,032). 4 hafta veya daha az, 4-6 hafta ve 6 haftadan uzun süreli DJS’lerin kolonizasyon oranları sırasıyla %27,5, %26 ve %50 idi (p=0,017). DJS kolonizasyonu, İYE görülmesi ve idrar kültürü pozitifliği ile pozitif korelasyon gösterdi (sırasıyla kappa (κ) katsayısı=0,100, κ=0,216, p<0,05). Çok değişkenli regresyon analizi, İYE’ye neden olan bağımsız risk faktörlerinin stent çıkarılmadan önceki idrar kültürünün pozitif olması (OR:29,487, p<0,001) ve >6 hafta DJS bulunma süresi (OR:7,584, p=0,003) olduğunu gösterdi.
Sonuç: İdrar kültürü pozitifliği ve DJS’nin 6 haftadan uzun sürmesi, DJS’li hastalarda üreteroskopik litotripsi sonrası İYE’yi öngörebilecek faktörlerdir. Ayrıca yüksek komorbidite skoru, İYE öyküsü ve idrar kültürü pozitifliği de DJS kolonizasyonu için bağımsız risk faktörleridir.

Anahtar Kelimeler

• kolonizasyon
• double j stent
• üreteroskopi
• idrar kültürü
• idrar yolu enfeksiyonu
• ürolitiyazis.

Destekleyen Kurum

yok

Kaynakça

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