The effects of autologous platelet concentrate on the healing of intra-bony defects: a randomized clinical trial

Abstract

Purpose

The present study aimed to evaluate the clinical and radiographic effects of

autologous platelet concentrate (APC) on the healing of intra-bony defects filled

with β-tricalcium phosphate (β-TCP) and covered with collagen membranes.

Subjects and methods

This study included 30 defects of 14 systemically healthy subjects. All of them had,

at least, two deep intra-bony, inter-proximal periodontal defects. Minimum probing

pocket depth (PPD) was 6 mm. Clinical and imaging examination was performed

both at baseline and at 3, 6, and 9 months after surgery.

Results

Both the test and control group revealed a significant reduction in all variables

when compared with the base line. Mean reduction of the PPD in two groups at

each follow-up time point showed no significant difference. Means of the clinical

attachment gain of the same groups were significantly different (p<0.05). Mean

gingival recession at 3 month was not significant. However, the means of gingival

recession coverage of two groups were significantly different at 6 and 9 months

(p<0.05 for both).

Conclusion

Sites treated with APC are more likely to demonstrate more clinical attachment gain

and recession coverage at the end of 9 month compared to those without APC.

Keywords

• Intra-bony defects,periodontal regeneration,periodontitis,latelet rich plasma,β‑tricalcium phosphate

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