Prevalence and predictors of molar-incisor hypomineralization among Egyptian children: a cross-sectional study

Yıl 2024, Cilt: 58 Sayı: 3, 120 - 126, 20.09.2024

Ahmed Mahmoud Etman , Rabaa Mahmoud Aboubakr , Doaa Alkhadragy

https://doi.org/10.26650/eor.20241394207

Öz

Purpose: The primary aim of this study was twofold: first, to assess the prevalence of molar incisor hypomineralization (MIH) within a cohort of Egyptian children and, second, to investigate the potential correlation between MIH and various factors, including age, sex, birth complications, and endogamous marriage.

Patients and Methods: This cross-sectional investigation took place in Egypt's Delta region, with approximately 3000 children aged between eight and twelve years being recruited for participation. The European Academy of Pediatric Dentistry (EAPD; 2003) criteria served as the diagnostic tool for identifying MIH cases. Upon detection of clinical signs or symptoms indicative of MIH, parents were queried regarding any potential birth complications or endogamous marriages. Lesion severity levels were diagnosed using Mathu-Muju and Wright criteria.

Results: The prevalence rate for MIH was found to be 7.2%. Molars exhibited higher susceptibility rates than incisors (64.8% vs 35.2%), with approximately 37% of participants displaying severe scores, followed by mild (33.8%) and moderate (29.2%). Male subjects had significantly more occurrences than females, with positive correlations identified between MIH incidence rates alongside each gender category as well as both birth complications and endogamous marriages.

Conclusion: Children born from complicated pregnancies or whose parents are related should receive frequent check-ups from pediatric dentists during their first permanent molar eruption period. so that early detection of MIH can be facilitated allowing timely intervention.

Anahtar Kelimeler

incisors, molars, hypomineralization, children, Egyptians

Mısır’lı çocuklarda büyük azı-kesici diş hipomineralizasyonunun prevalansı ve belirleyicileri: kesitsel bir çalışma

Öz

Amaç: Bu çalışmanın birincil amacı iki yönlüydü: birincisi, bir grup Mısırlı çocuk arasında büyük azı-kesici diş hipomineralizasyonu (MIH) prevalansını değerlendirmek ve ikincisi, MIH ile yaş, cinsiyet, doğum komplikasyonları ve akraba evliliği gibi çeşitli faktörler arasındaki olası korelasyonu araştırmak.

Hastalar ve Yöntemler: Bu kesitsel araştırma, Mısır’ın Delta bölgesinde gerçekleştirildi ve sekiz ile on iki yaşları arasında yaklaşık 3000 çocuk katılım için seçildi. MIH vakalarını belirlemek için Avrupa Pediatrik Diş Hekimliği Akademisi (EAPD; 2003) kriterleri tanı aracı olarak kullanıldı. MIH’ı gösteren klinik belirti veya semptomlar tespit edildiğinde, ebeveynlere olası doğum komplikasyonları veya akraba evlilikleri hakkında sorular soruldu. Lezyon şiddet seviyeleri Mathu-Muju ve Wright kriterlerine göre teşhis edildi.

Sonuçlar: MIH prevalans oranı %7,2 olarak bulundu. Büyük azı dişlerinde kesici dişlere göre daha yüksek duyarlılık oranları görüldü (%64,8’e karşı %35,2), katılımcıların yaklaşık %37’si ciddi skorlar gösterirken, bunu hafif (%33,8) ve orta (%29,2) dereceler izledi. Erkek denekler, kadınlara göre anlamlı derecede daha fazla vaka gösterdi ve MIH insidans oranları ile her iki cinsiyet kategorisinin yanı sıra hem doğum komplikasyonları hem de akraba evlilikleri arasında pozitif korelasyonlar tespit edildi.

Sonuç: Komplike gebeliklerden doğan veya ebeveynleri akraba olan çocuklar, ilk daimi büyük azı dişlerinin sürme döneminde pediatrik diş hekimleri tarafından sık sık kontrol edilmelidir. Bu şekilde MIH’ın erken tespiti sağlanarak zamanında müdahale yapılabilir.

Anahtar Kelimeler

kesici dişler, büyük azı dişleri, hipomineralizasyon, çocuklar, Mısırlılar

Kaynakça

• 1. Almuallem Z, Busuttil-Naudi A. Molar incisor hypomineralization (MIH) - an overview. Br Dent J 2018; 225: 601-9. google scholar
• 2. Garg N, Jain AK, Saha S, Singh J. Essentiality of early diagnosis of molar incisor hypomineralization in children and review of its clinical presentation, etiology, and management. Int J Clin Pediatr Dent 2012; 5:190-6. google scholar
• 3. Schwendicke F, Elhennawy K, Reda S, Bekes K, Manton DJ, Krois J. Global burden of molar incisor hypomineralization. J Dent 2018; 68:10-18. google scholar
• 4. Mahoney EK, Rohanizadeh R, Ismail FSM, Kilpatrick NM, Swain MV. Mechanical properties and microstructure of hypomineralized enamel of permanent teeth. Biomaterials 2004; 25:5091-100. google scholar
• 5. Weerheijm KL. Molar incisor hypomineralization (MIH): clinical presentation, etiology, and management. Dent Update 2004; 31:9-12. google scholar
• 6. Lygidakis NA, Wong F, Jalevik B, Vierrou AM, Alaluusua S, Espelid I. Best Clinical Practice Guidance for clinicians dealing with children presenting with Molar-Incisor-Hypomineralization (MIH). Eur Arch Paediatr Dent 2010; 11:75-81. google scholar
• 7. Zhang ZX, Zhang YM, Liu YY, Yang ZR, Jia J, Ren YF. Introduction and application of European Academy of Pediatric Dentistry judgment criteria and scoring system for molar-incisor hypomineralization. Zhonghua Kou Qiang Yi Xue Za Zhi. 2023; 58:944-52. google scholar
• 8. Zhao D, Dong B, Yu D, Ren Q, Sun Y. The prevalence of molar incisor hypomineralization: evidence from 70 studies. Int J Paediatr Dent 2018; 28:170-9. google scholar
• 9. Obeid AT, Antunes Garcia LH, de Lima Nascimento TR, Cancado Castellano LR, Soares Bombonatti JF, Honorio HM, et al. Effects of hybrid inorganic-organic nanofibers on the properties of enamel resin infiltrants - An in vitro study. J Mech Behav Biomed Mater 2022;126. google scholar
• 10. Saber F, Waly N, Moheb D. Prevalence of molar incisor hypomineralization in a group of Egyptian children using the short form: a cross-sectional study. Eur Arch Paediatr Dent 2018; 19:337-45. google scholar
• 11. Abd El Ghaffar A, Mahmoud S, fouad M. Prevalence of molar incisor hypomineralization among a group of Egyptian children: A cross sectional study. Egypt Dent J 2022; 68:29-37. google scholar
• 12. Senosy ASA, Mahmoud SA, Abdelgawad FKI. Prevalence of Molar Incisor Hypomineralization Among a Group of Egyptian Children in Fayoum governorate Schools: A Cross Sectional study. Advanced Dental Journal 2023; 5:659-69. google scholar
• 13. Osman SA, Elmasry ES, Abd Al Gawad RY. Prevalence of Molar Incisor Hypominerlization among a Group of Egyptian Children: A Cross Sectional study. Egypt Dent J 2020; 66:2021-8. google scholar
• 14. Alaluusua S. Etiology of Molar-Incisor Hypomineralization: A systematic review. Eur Arch Paediatr Dent 2010; 11:53-8. google scholar
• 15. Vieira AR, Kup E. On the Etiology of Molar-Incisor Hypomineralization. Caries Res 2016; 50:166-9. google scholar
• 16. Ghanim A, Manton D, MariNO R, Morgan M, Bailey D. Prevalence of demarcated hypomineralization defects in second primary molars in Iraqi children. Int J Paediatr Dent 2013; 23:48-55. google scholar
• 17. Dantas-Neta NB, Moura LdFAdD, Cruz PF, Moura MS, Paiva SM, Martins CC, et al. Impact of molar-incisor hypomineralization on oral health-related quality of life in schoolchildren. Braz Oral Res 2016; 30: e117. google scholar
• 18. de Barros LVC, Vale MP, Tourino L, Bittencourt JM, Bendo CB. Determination of dental caries, molar-incisor hypomineralization, and oral health-related quality of life in schoolchildren: A structural equation modeling approach. Int J Paediatr Dent 2023; 33:289-97. google scholar
• 19. Padavala S, Sukumaran G. Molar Incisor Hypomineralization and Its Prevalence. Contemp Clin Dent 2018;9: S246-s50. google scholar
• 20. Mathu-Muju K, Wright JT. Diagnosis, and treatment of molar incisor hypomineralization. Compend Contin Educ Dent 2006; 27:604-10. google scholar
• 21. Yamunadevi A, Pratibha R, Rajmohan M, Mahendraperumal S, Ganapathy N, Srivandhana R. First Molars in Permanent Dentition and their Malformations in Various Pathologies: A Review. J Pharm Bioallied Sci 2021;13: S23-s30. google scholar
• 22. Weerheijm KL, Groen HJ, Beentjes VE, Poorterman JH. Prevalence of cheese molars in eleven-year-old Dutch children. ASDC J Dent Child 2001; 68:259-62. google scholar
• 23. Almuallem Z, Alsuhaim A, Alqudayri A, Aljarid S, Mousa Alotaibi M, Alkraida R, et al. Prevalence and possible etiological factors of molar incisor hypomineralization in Saudi children: A cross-sectional study. Saudi Dent J 2022; 34:36-44. google scholar
• 24. Allazzam SM, Alaki SM, El Meligy OAS. Molar Incisor Hypomineralization, Prevalence, and Etiology. Int J Dent 2014; 2014:234508. google scholar
• 25. Al-Nerabieah Z, AlKhouli M, Dashash M. Prevalence, and clinical characteristics of molar-incisor hypomineralization in Syrian children: a cross-sectional study. Sci Rep 2023; 13:8582. google scholar
• 26. Hamdan M, Abu-Ghefreh EA, Al-Abdallah M, Rajab LD. The prevalence and severity of molar incisor hypomineralization (MIH) among 8-year-old children in Amman, Jordan. Egypt Dent J 2020; 66:1989-97. google scholar
• 27. Zawaideh FI, Al-Jundi SH, Al-Jaljoli MH. Molar incisor hypomineralization: prevalence in Jordanian children and clinical characteristics. Eur Arch Paediatr Dent 2011; 12:31-6. google scholar
• 28. Abdalla HE, Abuaffan AH, Kemoli AM. Molar incisor hypomineralization, prevalence, pattern, and distribution in Sudanese children. BMC Oral Health 2021; 21:9. google scholar
• 29. Lopes, L.B., Machado, V., Mascarenhas, P. et al. The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis. Sci Rep 2021; 11: 22405. google scholar
• 30. Bukhari ST, Alhasan HA, Qari MT, Sabbagh HJ, Farsi NM. Prevalence and risk factors for molar incisor hypomineralization in the Middle East: A systematic review and meta-analysis. J Taibah Univ Med Sci 2022; 18:696-710. google scholar
• 31. Nisii F, Mazur M, De Nuccio C, Martucci C, Spuntarelli M, Labozzetta S, et al. Prevalence of molar incisor hypomineralization among school children in Rome, Italy. Sci Rep 2022; 12:7343. google scholar
• 32. Mishra A, Pandey RK. Molar incisor hypomineralization: An epidemiological study with prevalence and etiological factors in Indian pediatric population. Int J Clin Pediatr Dent 2016; 9:167-71. google scholar
• 33. Alhowaish L, Baidas L, Aldhubaiban M, Bello LL, Al-Hammad N. Etiology of Molar-Incisor Hypomineralization (MIH): A Cross-Sectional Study of Saudi Children. Children (Basel) 2021; 8: 466. google scholar
• 34. Bahrololoomi Z, Amrollahi N, Mostafaloo N. The Prevalence and Extent of Molar-Incisor Hypo-Mineralization by Gender in a Group of Iranian Children. Iran J Public Health 2020; 49:1585-7. google scholar
• 35. Pitiphat W, Luangchaichaweng S, Pungchanchaikul P, Angwaravong O, Chansamak N. Factors associated with molar incisor hypomineralization in Thai children. Eur J Oral Sci 2014; 122:265-70. google scholar
• 36. Juarez-Lopez MLA, Salazar-Treto LV, Hernandez-Monjaraz B, Molina-Frechero N. Etiological Factors of Molar Incisor Hypomineralization: A Systematic Review and Meta-Analysis. Dent J (Basel) 2023; 11:111. google scholar
• 37. Berenstein Ajzman G, Dagon N, Iraqi R, Blumer S, Fadela S. The Prevalence of Developmental Enamel Defects in Israeli Children and Its Association with Perinatal Conditions: A Cross-Sectional Study. Children (Basel) 2023;10. google scholar
• 38. Garot E, Rouas P, Somani C, Taylor GD, Wong F, Lygidakis NA. An update of the etiological factors involved in molar incisor hypomineralization (MIH): a systematic review and meta-analysis. Eur Arch Paediatr Dent 2022; 23: 39-64. google scholar
• 39. Jeremias F, Pierri RA, Souza JF, Fragelli CM, Restrepo M, Finoti LS, et al. Family-Based Genetic Association for Molar-Incisor Hypomineralization. Caries Res 2016; 50:310-18. google scholar
• 40. Stephanopoulos G, Garefalaki ME, Lyroudia K. Genes and related proteins involved in amelogenesis imperfecta. J Dent Res 2005; 84:1117-26. google scholar