New Fused Hyterocyclic Compounds: Synthesis of Some 1,4-di[1,2,4- Triazoles[3,4-b]5-phnyl/aryl-1,3,4-thiadiazole] Benzene

Yıl 2018, Sayı: 2, 39 - 48, 19.08.2018

Mohanad Yakdhan Saleh

Öz

In
this paper the synthesis of some substituted di – 1,2,4-triazoles and it is
conversion to multi nuclear heterocyclic compounds ; described Terphthalic acid
was esterified to its ethyl ester(1)by its reaction with absolute ethanol ,
concentrated sulfuric acid , the ethyl ester (1) was treated with hydrazine
hydrate is ethanol to give the acid hydrazide (2). the hydrazide (2) then
treated with ammonium thiocyanate to give thiosemicarbazide (3) , reaction of
thiosemicarbazide (3) with  hydrazine
hydrate gave  1,4-bis(
3-thiol-4-amino-1,2,4-triazole-5-yl) benzene (4). Compound (4) treatment with
three type substituted benzaldehyde gave 1,4-di hydrazones phenyl (5,6 and 7).
Cyclization hydrazones compounds (5,6,7) with phosphorous oxychloride in xylene
to gave bicyclic system 1,4-bis[1,2,4-triazole[3,4-b]-5-substituted –
1,3,4-thiadiazole] benzene (8,9 and 10) 
. On the other hand some physical parameters of compounds ( 4 -10 )
under investigation such as the Mullikan charge at the active atoms, HOMO and
LUMO energy levels , hardness (η) , electronic chemical potential (µ) and global electrophilicty index (W) were theoretically calculated using ( Gaussian program ). The
antibacterial activity some of the synthesis compounds was studied. The
structures of the synthesized compounds were confirmed by physical and spectral
methods.

Anahtar Kelimeler

Hyterocyclic, Triazoles, Thiadiazole, Terphthalic acid

Kaynakça

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