Cytotoxic Activity Against Cancer Cells of Pistacia vera

Yıl 2018, Sayı: 2, 265 - 269, 19.08.2018

Basak Sımıtcıoglu Ahmet Cakır İbrahim Halil Kılıc Mehmet Ozaslan İsik Didem Karagoz

Öz

Pistacia vera
fruit, one of the leading products of today's sweet and snack sector, which has
been seen in the history of the kingdom, are able to support daily nutritional
needs and treatment of many diseases due to the phenolic and flavonoid content
in the literature. Especially the studies on colon cancer and breast cancer are
remarkable potential antitumoral activity of pistachio examined. The aim of
this study is to examine in more detail the P.
vera plant, in which we have previously tested the methanol-hexane extracts
of the seed and the test and obtained positive results. As well as observing
the cytotoxic activities of the plant extracts and active ingredients obtained
from different parts on the lung cancer cells. After counting A549 and HUVEC
cell lines which replicated in the medium, were added on 96 well plate. Then,
different part of plants extract and 2 major active ingredients also added.
Then MTT dye was applied and measured spectrophotometrically. P. vera extracts and active ingredients
which studied cytotoxic activity research were found to be effective in all
cell lines in general. Particularly P.
vera's remaining after the fruit parts, methanol extract which obtained
from waste containing leaf and stem parts and PVK-1 active agent showed
selective activity on normal cells and cancer cells, therefore we consider that
it has a high therapeutic index. We believe that this plant should be imparted
to sciences and health sector with further studies.

Anahtar Kelimeler

Pistacia vera, Lung cancer, Cytotoxic activitiy, Phytotherapy

Kaynakça

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