Overcoming Centrosome Duplication Defects by the SESA Network

Yıl 2018, Sayı: 4, 82 - 86, 04.12.2018

Bengu Erguden

Öz

The
correct separation of chromosomes during mitosis is necessary to prevent
genetic instability and aneuploidy which causes cancer, and other diseases. The
main criteria for this is the correct duplication of the centrosome. Recently,
we reported that Smy2 can suppress the essential role of MPS2 in the insertion of yeast centrosome into the nuclear membrane
and co-operates with Eap1, Scp160, Asc1 for this task. We gave the name SESA (Smy2,
Eap1, Scp160, Asc1) network to the system consisting of
these four proteins. Detailed analysis showed that the SESA system is part of a
mechanism which regulates translation of POM34
mRNA. Thus, SESA, is a system which suppresses spindle pole body (SPB)
duplication defects by inhibiting the translation of POM34 mRNA (Sezen,
et al., 2009). Although many important points regarding SESA network
have been discovered, many others remain obscure. In this study, we performed a
genome-wide screen in order to unearth new members of the system and showed
that Dhh1 is a member of the SESA network. Dhh1 is a known cytoplasmic DEAD-box
helicase known to play role in translational regulation. Thus we propose that
Dhh1 contributes to the highly selective nature of the inhibition of translation
by SESA system.

Anahtar Kelimeler

S. cerevisiae, Centrosome duplication, Translational control, SESA network

Kaynakça

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