The Relationship between Zinc, Copper and Manganese Levels on Bone Formation, Which Increases the Risk of Uterine Cancer

Yıl 2018, Sayı: 4, 108 - 112, 04.12.2018

Zena A.m. Aljawadı

Öz

Due to
the lack of previous studies on the impact of osteoporosis on the incidence of
uterine cancer, and the rapid spread of uterine cancer in recent years all the
world, and the exact mechanism of its occurrence is not entirely clear. The
study focused on the possibility of consideration of osteoporosis as a marker
to uterine cancer by study the relationship between osteoporosis and uterine cancer
through the measurement of both Zinc, Copper and Manganese which operate inside
the body as antioxidation when its linked with enzymes, which affect the bone
density and their impact on the incidence of uterine cancer. The study involved
collecting samples from hospitals in Mosul, women without uterine cancer as the
control group and divided into two groups (44 women with good health and 38
women diagnosed as osteoporosis only). And patients women also divided to the
two groups did not receive any treatment (43 with uterine cancer only and 58
women with osteoporosis and uterine cancer). Each patient was evaluated
clinically and then was estimated Zinc, Copper and Manganese in serum using
atomic absorption spectroscopy technique as well as appreciation of both
estrogen and progesterone in the serum. The results showed that osteoporosis
may increase the incidence of uterine cancer through hormonal changes and the
concentration of antioxidants and their impact on the bone-building and thus
its impact on the amount of free radicals in the body which cause increase the
likelihood of uterine cancer before and after menopause. The study showed that
osteoporosis is a new risk factors increase the likelihood of uterine cancer.
Women should pay attention to bone health by maintaining the concentration of
antioxidant mineral, which has a role in bone health and prevent fragility and
early diagnosis and treatment of osteoporosis to reduce the risk of uterine
cancer.

Anahtar Kelimeler

Uterine cancer, Zinc, Copper, Osteoporosis

Kaynakça

• Yang, S., Thiel, K. W. and Leslie, K. K., Trends in Endocrinology & Metabolism Progesterone 22(4): 145-152, (2011). Haughian, J. M., Reno, E. M., Thorne, A. M., and Bradford, A. P., Int J Cancer.125(11): 2556-2564, (2009). Colombo, N., Preti, E., Landoni, F., Carinelli, S., Colombo, A., Marini, C. and Sessa, C., Ann Oncol. 22(6): 35-39, (2011). Haughian, J. M., Jackson, T. A., Koterwas, D. M. and Bradford, A. P., Endocrine-Related Cancer. 13: 1251-1267, (2006). Demirci, S., Ozsaran, Z., Celik, H. A., Aras, A. B. and Aydin, H. H., Tumori. 97: 290-295, (2011). Badjatia, N., Satyam, A., Singh, P., Seth, A. and Sharma, A., Urol Oncol. 28: 360-367, (2010). Gokul, S., Patil, V. S., Jailkhani, R., Hallikeri, K. and Kattappagari, K.K., Oral Dis. 16: 29-33, (2010). Sugiura , M., Nakamura, M., Ogawa, K., Ikoma, Y., Ando, F., Shimokata , H., and Yano, M., International Osteoporosis Foundation and National Osteoporosis Foundation. 22: 143-152, (2010). Sendur, O. S., Turan, Y., Tastaban, E. and Serter, M., Joint bone spine. 76(5): 514 – 518, (2009). Chuin, A., Labonté, M., Tessier, D., Khalil, A., Bobeuf, F., Doyon, C. Y., Rieth, N. and Dionne, I. J., International Osteoporosis Foundation and National Osteoporosis Foundation. 20(7): 1253-1258, (2009). Sahni, S., Hannan, M. T., Gagnon, D., Blumberg, J., Cupples, L.A ., Kiel, D.P., and Tucker, K.L., International Osteoporosis Foundation and National Osteoporosis Foundation. 20(11): 1853-1861, (2009). Richmond, S. J., Brown, S. R., Campion, P. D., Porter, A. J., Moffett, J. A., Jackson, D. A., Featherstone, V. A. and Taylor, A. J., Complement Ther Med. 17(5-6): 249-256, (2009). Kazi, T. G., Afridi, H. I., Kazi, N., Jamali, M. K., Biol Trace Elem Res. 122(1): 1-18, (2008). Antanasopoulos N., Flame methods manual for atomic absorption, published by GBC scientific equipment PTY Ltd, 2010. Kirkpatrick L. Feeney B. C. A Simple Guide to IBM SPSS Statistics for Version 18.0 and 19.0 11th Edn., Wadsworth Cengage Learning, Belmont, ISBN-10:1111352550,2012; P115. Kim, H. J., Kim, T. J. and Lee, Y. Y., J Gynecol Oncol. 24(2): 120-127, (2013). Llaurado, M., Ruiz, A., Majem, B., Ertekin, T., Colas, E., Pedrola, N. and Reventos, J., Molecular and cellular endocrinology. 358(2): 244-255, (2012). Lee, W. L., Lee, F. K., Su, W. H., Tsui, K. H., Kuo, C. D., Hsieh, S. L. and Wang, P. H., Taiwanese journal of obstetrics & gynecology. 51(4): 495-505, (2012). McTiernan, A., Irwin, M. and Vongruenigen, V., Journal of clinical oncology. 28(26): 4074-4080, (2010). Wehrli, F. W., J Bone Miner Res. 23(5): 730-740, (2008). Raisz, L. G., Pathogenesis of osteoporosis: concepts, conflicts and prospects. J Clin Invest. 115: 3318-3325, (2005). Orenzo, J., Horowitz, M. and Choi, Y., Endocrine Reviews. 29(4): 403-440, (2008). Mackinnon, E. S., Rao, A. V. and Rao, L. G., The Journal of Nutrition, Health & Aging.15(2): 133-138, (2011). Baek, K. H., Oh, K. W., Lee, W. Y., Lee, S. S., Kim, M. K. and Kwon, H. S., Calcified Tissue International. 87(3): 226-235, (2010). Zhang, J., Munger, R.G., West, N. A., Cutler, D. R, Am. J. Epidemiol. 163 (1): 9-17, (2006). Medeiros Pinheiro, M., Ciconelli, R. M., Chaves, G. V., Aquino, L., Juzwiak, C. R., Genaro, P. D. S. and Ferraz, M. B., Nutrition Journal. 10(39): 1-8, (2011). Berger, M.M., Clin Nutr. 24: 172-83, (2005). Clark, S. F., Nutr Clin Pract. 17: 5-17, (2002). Oveisi, M. R., Sadeghi, N,. Jannat, B., Hajimahmoodi, M., Hadjibabaie, M. and Behfar, A., Iranian Journal of Basic Medical Sciences. 14(2): 158-166, (2011). Chavan, S. N., More, U., Mulgund, S., Saxena, V. and Sontakke, A. N., Indian Journal of Clinical Biochemistry. 22 (2): 101-105, (2007).