A
new series of five and six membered ring heterocyclic compounds were
synthesized using 2-[(2,6-dichloroanilino) phenyl] acetic acid (Dichlofenac)
(1) as starting material. This compound was converted to its ethyl ester
derivative (2) via the acid catalyzed esterification. The ester (2) was
converted to the hydrazide derivative (3) through its reaction with hydrazine
hydrate. The hydrazide (3) was used as precursor to synthesize the heterocycle
containing compounds. Moreover, the hydrazide (3) was converted to the
thiosemicarbazide derivatives (5-7) by their reaction with isothiacyanate
compounds. The compounds (5-7) were converted to five membered ring
heterocyclic compounds, such as, 1,3,4-triazols (8, 9, 12, 13),
1,3,4-thiadiazoles (10, 11) and 1,3,4-oxadiazol (14) under the influence of a
miscellaneous of reagents. The cabohydrazide (3) was incorporated in to
1,3,4-oxadiazol (4), phthalimido derivative (15), tetrazine
compound (17), pyrazolines (18-22) and isocyanate compound (24). All the
synthesized compounds were characterized by physical and spectral data.
1-3-4 oxadiazole 1-3-4 thiadiazole 1-3-4 triazole Tetrazine Thiosemicarbazide
Birincil Dil | İngilizce |
---|---|
Konular | Mühendislik |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 4 Aralık 2018 |
Yayımlandığı Sayı | Yıl 2018Sayı: 4 |