Yıl 2019, Cilt 7 , Sayı , Sayfalar 93 - 98 2019-11-24

Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds

Mohammed Ahmed AL-IRAQI [1] , Rand Arshad SAAD-ALDEEN [2]


Quinazolin-4(3H)-one is a well-known heterocyclic compound with a unique place in medicinal chemistry, and it has drawn much attention due to its diversified biological activity. In this research we report the synthesis of some quinazolin-4-one derivatives containing acetylenic moiety. The quinazolin-4(3H)-one (1) was synthesized from the reaction of anthranilic acid with formamide under the conventional or microwave irradiation conditions. The quinazolin-4(3H)-one was converted to the corresponding 3-propargyl derivative (2) by its reaction with propargyl bromide in presence of potassium carbonate as a base and acetone as a solvent. The 3-propargyl quinazolin-4(3H)-one (2) was used as a precursor to synthesize new three series of heterocyclic compounds containing quinazolin-4(3H)-one moiety. Compound (2) was treated with ethyl magnesium bromide, then the resulted solution treated immediately with carbon disulfide and sublimed sulfur to synthesize 1,2-dithiol-3-thione compound (3). The 1,2,3-triazole compounds (5a-d) were synthesized by the reaction of compound (2) with alkyl azides (4a-d) according to Click reaction. The Mannich bases (6a-i) were synthesized via Mannich reaction by reaction of the acetylenic compound (2) with secondary amines in presence of paraformaldehyde in1,4-dioxane as a solvent. All the synthesized compounds were characterized by physical and spectral measurements.
Quinazolin-4-one, 2-dithiol-3-thione, 1, 2, 3-triazole, Click reaction, Mannich reaction
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Birincil Dil en
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Yazar: Mohammed Ahmed AL-IRAQI
Kurum: University of Mosul
Ülke: Iraq


Yazar: Rand Arshad SAAD-ALDEEN
Kurum: University of Mosul
Ülke: Iraq


Tarihler

Yayımlanma Tarihi : 24 Kasım 2019

Bibtex @araştırma makalesi { epstem653237, journal = {The Eurasia Proceedings of Science Technology Engineering and Mathematics}, issn = {}, eissn = {2602-3199}, address = {isresoffice@gmail.com}, publisher = {ISRES Organizasyon Turizm Eğitim Danışmanlık Ltd. Şti.}, year = {2019}, volume = {7}, pages = {93 - 98}, doi = {}, title = {Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds}, key = {cite}, author = {SAAD-ALDEEN, Rand Arshad} }
APA AL-IRAQI, M , SAAD-ALDEEN, R . (2019). Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds. The Eurasia Proceedings of Science Technology Engineering and Mathematics , 7 () , 93-98 . Retrieved from https://dergipark.org.tr/tr/pub/epstem/issue/50288/653237
MLA AL-IRAQI, M , SAAD-ALDEEN, R . "Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds". The Eurasia Proceedings of Science Technology Engineering and Mathematics 7 (2019 ): 93-98 <https://dergipark.org.tr/tr/pub/epstem/issue/50288/653237>
Chicago AL-IRAQI, M , SAAD-ALDEEN, R . "Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds". The Eurasia Proceedings of Science Technology Engineering and Mathematics 7 (2019 ): 93-98
RIS TY - JOUR T1 - Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds AU - Mohammed Ahmed AL-IRAQI , Rand Arshad SAAD-ALDEEN Y1 - 2019 PY - 2019 N1 - DO - T2 - The Eurasia Proceedings of Science Technology Engineering and Mathematics JF - Journal JO - JOR SP - 93 EP - 98 VL - 7 IS - SN - -2602-3199 M3 - UR - Y2 - 2020 ER -
EndNote %0 The Eurasia Proceedings of Science Technology Engineering and Mathematics Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds %A Mohammed Ahmed AL-IRAQI , Rand Arshad SAAD-ALDEEN %T Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds %D 2019 %J The Eurasia Proceedings of Science Technology Engineering and Mathematics %P -2602-3199 %V 7 %N %R %U
ISNAD AL-IRAQI, Mohammed Ahmed , SAAD-ALDEEN, Rand Arshad . "Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds". The Eurasia Proceedings of Science Technology Engineering and Mathematics 7 / (Kasım 2019): 93-98 .
AMA AL-IRAQI M , SAAD-ALDEEN R . Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds. EPSTEM. 2019; 7: 93-98.
Vancouver AL-IRAQI M , SAAD-ALDEEN R . Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds. The Eurasia Proceedings of Science Technology Engineering and Mathematics. 2019; 7: 98-93.

Makalenin Yazarları
Mohammed Ahmed AL-IRAQI [1]
Rand Arshad SAAD-ALDEEN [2]