Bisfenol A İçerikli Rezin Esaslı Dental Materyallerde Bisfenol A Salınımı ve İnsan Vücuduna Östrojenik Etkilerinin İncelenmesi

Abstract

Dünyada her yıl 5 milyon tonu aşkın üretim kapasitesiyle en çok kullanılan ürün olan Bisfenol A, endokrin bozucu kimyasallar arasında yer almaktadır. Dayanıklı yapısıyla plastikler, gıda saklama kapları, plastik su şişeleri, elektronik cihazlar, metal konserve ve içecek kutularının iç yüzey kaplamaları, bebek biberonları, diş hekimliğinde kullanılan dolgu malzemeleri ve çürükten koruma amacıyla yaygın kullanılan fissür örtücüler gibi çok çeşitli ve yaygın alanda karşımıza çıkmaktadır. Geniş bir yelpazede kullanım alanına sahip olan Bisfenol A, canlılarda ksenoöstrojen olarak etki göstermektedir. Diş hekimliğinde kullanılan bazı materyaller, hava, su, toprak, besinler gibi çeşitli kaynaklardan Bisfenol A ile maruziyet söz konusudur ve bu maruziyetler sonucu vücutta toksik etkiler görülebilmektedir. Bisfenol A ile maruziyetle meydana gelebilecek etkilerin önemli bir halk sağlığı problemi olduğu düşünülmekte ve bu konuda yapılan çalışmalar her geçen gün artmaktadır. Bu derlemede Bisfenol A’nın yapısı, insan vücudundaki yazgısıyla beraber doz bağımlı östrojenik etkileri, diş hekimliğinde kullanılan kompozit restoratif dolgu materyali ve fissür örtücülerindeki yeri ile Bisfenol A sızıntılarının östrojenik etkileri arasındaki bağlantı incelenmiştir. İncelenen çalışmalar net bir kanıda buluşmasa da, dental tedavilerde kompozit ve fissür örtücü uygulanması ile Bisfenol A ile maruziyet söz konusu olabileceği ve uzun dönemde sağlık üzerine olumsuz etkileri olabileceği ortaya konmuştur.

Keywords

• Bisfenol A
• kompozit
• fissür örtücü
• östrojen

Bisphenol A Release in Resin-Based Dental Materials Containing Bisphenol A and Investigation of Estrogenic Effects on Human Body

Abstract

Bisphenol A, which is the most used product in the world with a production capacity of more than 5 million tons every year, is among the endocrine disrupting chemicals. With its durable structure, plastics, food storage containers, plastic water bottles, electronic devices, inner surface coatings of metal can and beverage cans, baby bottles, filling materials used in dentistry and fissure sealants that are widely used for decay protection, are encountered in a wide range of and widespread areas. Bisphenol A has a wide range of uses and acts as a xenoestrogen. There are several exposure routes of Bisphenol A from various sources such as some materials used in dentistry, air, water, soil and nutrients and toxic effects can be seen in the body as a result of these exposures. These effects are considered to be an important public health problem, and studies on this subject are increasing day by day. In this review, the structure of Bisphenol A, its dose-dependent estrogenic effects along with its fate in the human body, its place in composite restorative filling materials and fissure sealants used in dentistry, and the relationship between the estrogenic effects of Bisphenol A leaks were investigated. Although the studies examined do not meet a clear conclusion, it has been revealed that the application of composite and fissure sealant in dental treatments may lead to Bisphenol A exposure and may have negative effects on health in the long term.

Keywords

• bisphenol a
• composite
• fissure sealant
• estrogen

References

1. Akyüz, S., Yarat, A., & Egil, E. (2011). Bisfenol-A içerikli dental materyallere güncel yaklaşım. Clinical and Experimental Health Sciences, 1(3), 190-195.
2. Alonso-Magdalena, P., Vieira, E., Soriano, S., Menes, L., Burks, D., Quesada, I., & Nadal, A. (2010). Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring. Environmental health perspectives, 118(9), 1243-1250.
3. Atalayın, Ç., Tezel, H., & Ergücü, Z. (2016). Rezin Esaslı Dental Materyallerin Sitotoksisitesine Genel Bir Bakış.
4. Ayazgök, B., & Küçükkilinç, T. T. (2017). Düşük Doz Bisfenol A'nın Büyük Etkileri. FABAD Journal of Pharmaceutical Sciences, 42(2), 139.
5. Battal D. Mersin İlinde Yaşayan Bireylerdeki Bisfenol A Düzeyinin Belirlenmesi. Mersin Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, 2012, Mersin (Danışman: Prof. Dr. Bahar Tunçtan, Prof. Dr. İsmet Çok)
6. Bergman, Å., Heindel, J. J., Jobling, S., Kidd, K., Zoeller, T. R., & World Health Organization. (2013). State of the science of endocrine disrupting chemicals 2012. World Health Organization.
7. Bondesson, M., Jönsson, J., Pongratz, I., Olea, N., Cravedi, J. P., Zalko, D., Manthey, D. vd. (2009). A CASCADE of effects of bisphenol A. Reproductive toxicology (Elmsford, NY), 28(4), 563.
8. Carwile, J. L., & Michels, K. B. (2011). Urinary bisphenol A and obesity: NHANES 2003–2006. Environmental research, 111(6), 825-830.

9. Choi, S. M., Yoo, S. D., & Lee, B. M. (2004). Toxicological characteristics of endocrine-disrupting chemicals: developmental toxicity, carcinogenicity, and mutagenicity. Journal of Toxicology and Environmental Health, Part B, 7(1), 1-23.
10. Chung, S. Y., Kwon, H., Choi, Y. H., Karmaus, W., Merchant, A. T., Song, K. B., Kang, D. vd. (2012). Dental composite fillings and bisphenol A among children: a survey in South Korea. International dental journal, 62(2), 65-69.
11. Colborn, T. (2004). Neurodevelopment and endocrine disruption. Environmental health perspectives, 112(9), 944-949.
12. Corrales, J., Kristofco, L. A., Steele, W. B., Yates, B. S., Breed, C. S., Williams, E. S., & Brooks, B. W. (2015). Global assessment of bisphenol A in the environment: review and analysis of its occurrence and bioaccumulation. Dose-Response, 13(3), 1559325815598308.
13. Davis, D. L., Bradlow, H. L., Wolff, M., Woodruff, T., Hoel, D. G., & Anton-Culver, H. (1993). Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environmental health perspectives, 101(5), 372-377.
14. Diamanti-Kandarakis, E., Bourguignon, J. P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Gore, A. C. vd. (2009). Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocrine reviews, 30(4), 293-342.
15. Dodds, E. C., & Lawson, W. (1936). Synthetic strogenic agents without the phenanthrene nucleus. Nature, 137(3476), 996-996.
16. Durmaz, E., & BK, G. (2013). Çevresel bir endokrin bozucu: Bisfenol A ve toksik etkilerinin değerlendirilmesi. Çocuk Sağlığı ve Hastalıkları Dergisi, 56, 192-9.
17. European Food Safety Authority (EFSA), 2015. No consumer health risk from bisphenol A exposure. Erişim adresi: https://www.efsa.europa.eu/en/press/news/150121 Erişim tarihi: 20 Kasım 2020.
18. Fendoğlu, B. Y., Koçer-Gümüşel, B., & Erkekoğlu, P. Endokrin Bozucu Kimyasal Maddeler ve Kanser Arasındaki İlişkinin Değerlendirilmesi ve Korunma Önerileri. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, 39(1), 44-57.
19. Fendoğlu, B. Y., Koçer-Gümüşel, B., & Erkekoğlu, P. Endokrin Bozucu Kimyasal Maddelere ve Etki Mekanizmalarına Genel Bir Bakış. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, 39(1), 30-43.
20. Fernandez, M. F., Arrebola, J. P., Taoufiki, J., Navalón, A., Ballesteros, O., Pulgar, R., Olea, N. vd. (2007). Bisphenol-A and chlorinated derivatives in adipose tissue of women. Reproductive toxicology, 24(2), 259-264.
21. Fleisch, A. F., Sheffield, P. E., Chinn, C., Edelstein, B. L., & Landrigan, P. J. (2010). Bisphenol A and related compounds in dental materials. Pediatrics, 126(4), 760-768.
22. Freitas, J., Cano, P., Craig-Veit, C., Goodson, M. L., Furlow, J. D., & Murk, A. J. (2011). Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay. Toxicology in Vitro, 25(1), 257-266.
23. Fung, E. Y., Ewoldsen, N. O., GERMAIN JR, H. A. S., Marx, D. B., MIAW, C. L., Siew, C., Meyer, D. M. vd. (2000). Pharmacokinetics of bisphenol A released from a dental sealant. The journal of the american dental association, 131(1), 51-58.
24. Gao, H., Yang, B. J., Li, N., Feng, L. M., Shi, X. Y., Zhao, W. H., & Liu, S. J. (2015). Bisphenol A and hormone-associated cancers: current progress and perspectives. Medicine, 94(1).
25. Geens, T., Aerts, D., Berthot, C., Bourguignon, J. P., Goeyens, L., Lecomte, P., Van Loco, J. vd. (2012). A review of dietary and non-dietary exposure to bisphenol-A. Food and chemical toxicology, 50(10), 3725-3740.
26. Ginsberg, G., & Rice, D. C. (2009). Does rapid metabolism ensure negligible risk from bisphenol A?. Environmental health perspectives, 117(11), 1639-1643.
27. Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Zoeller, R. T. vd. (2015). EBK-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals. Endocrine reviews, 36(6), E1-E150.
28. Gould, J. C., Leonard, L. S., Maness, S. C., Wagner, B. L., Conner, K., Zacharewski, T., Gaido, K. W. vd. (1998). Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol. Molecular and cellular endocrinology, 142(1-2), 203-214.
29. Gül, P. & Akgül, N. (2013). Kompozit Materyallerin Biyouyumluluğu Hakkında Literatür Derlemesi. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 23.
30. Harorlı, O. T. Triethylene Glycol Dimethacrylate (TEGDMA)’ın Biyouyumluluğunun Hücre Kültürü Yöntemi ile Sitomorfolojik Olarak İncelenmesi. Atatürk Üniversitesi Sağlık Bilimleri Enstitüsü, Doktora Tezi, 2009, Erzurum (Danışman: Doç. Dr. Y. Z. Bayındır)
31. HIROI, H., TSUTSUMI, O., MOMOEDA, M., TAKAI, Y., OSUGA, Y., & TAKETANI, Y. (1999). Differential interactions of bisphenol A and17β-estradiol with estrogen receptor α (ERα) and ERβ. Endocrine journal, 46(6), 773-778.
32. İnce O.T. Tip I Diyabetli Çocuklarda Bisfenol A Maruziyeti ve İdrar Bisfenol A Düzeyleri. Hacettepe Üniversitesi Sağlık Bilimleri Enstitüsü, Doktora Tezi, 2017, Ankara (Danışman: Prof. Dr. Kadriye Yurdakök)
33. Kabir, E. R., Rahman, M. S., & Rahman, I. (2015). A review on endocrine disruptors and their possible impacts on human health. Environmental toxicology and pharmacology, 40(1), 241-258.
34. Kang, J. H., Aasi, D., & Katayama, Y. (2007). Bisphenol A in the aquatic environment and its endocrine-disruptive effects on aquatic organisms. Critical reviews in toxicology, 37(7), 607-625.
35. Kang, J. H., Katayama, Y., & Kondo, F. (2006). Biodegradation or metabolism of bisphenol A: from microorganisms to mammals. Toxicology, 217(2-3), 81-90.
36. Konieczna, A., Rutkowska, A., & Rachon, D. (2015). Health risk of exposure to Bisphenol A (BFA). Roczniki Państwowego Zakładu Higieny, 66(1).
37. Kuiper, G. G., Lemmen, J. G., Carlsson, B. O., Corton, J. C., Safe, S. H., Van Der Saag, P. T., Gustafsson, J. A. vd. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology, 139(10), 4252-4263.
38. La Rocca, C., Tait, S., Guerranti, C., Busani, L., Ciardo, F., Bergamasco, B., Caserta, D. vd. (2015). Exposure to endocrine disruptors and nuclear receptors gene expression in infertile and fertile men from Italian areas with different environmental features. International journal of environmental research and public health, 12(10), 12426-12445.
39. Lagos-Cabré, R., & Moreno, R. D. (2012). Contribution of environmental pollutants to male infertily: a working model of germ cell apoptosis induced by plasticizers. Biological research, 45(1), 5-14.
40. LaKind, J. S., Goodman, M., & Mattison, D. R. (2014). Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: a systematic review of epidemiologic research. Critical reviews in toxicology, 44(2), 121-150.
41. Löfroth, M., Ghasemimehr, M., Falk, A., & von Steyern, P. V. (2019). Bisphenol A in dental materials–existence, leakage and biological effects. Heliyon, 5(5), e01711.
42. Mahamuni, D., & Shrinithivihahshini, N. D. (2019). Inferring Bisphenol-A influences on estrogen-mediated signalling in estrogen and androgen receptors: an in silico approach. Biocatalysis and Agricultural Biotechnology, 20, 101178.
43. Marmugi, A., Lasserre, F., Beuzelin, D., Ducheix, S., Huc, L., Polizzi, A., Mselli-Lakhal, L. vd. (2014). Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Toxicology, 325, 133-143.
44. McKinney, C., Rue, T., Sathyanarayana, S., Martin, M., Seminario, A. L., & DeRouen, T. (2014). Dental sealants and restorations and urinary bisphenol A concentrations in children in the 2003-2004 National Health and Nutrition Examination Survey. The Journal of the American Dental Association, 145(7), 745-750.
45. McKinney, J. D., & Waller, C. L. (1994). Polychlorinated biphenyls as hormonally active structural analogues. Environmental Health Perspectives, 102(3), 290-297.
46. McKinney, J. D., & Waller, C. L. (1998). Molecular determinants of hormone mimicry: halogenated aromatic hydrocarbon environmental agents. Journal of Toxicology and Environmental Health, Part B Critical Reviews, 1(1), 27-58.
47. Miller, W. R., & Sharpe, R. M. (1998). Environmental oestrogens and human reproductive cancers. Endocrine-related cancer, 5(2), 69-96.
48. Moriyama, K., Tagami, T., Akamizu, T., Usui, T., Saijo, M., Kanamoto, N., Nakao, K. vd. (2002). Thyroid hormone action is disrupted by bisphenol A as an antagonist. The Journal of Clinical Endocrinology & Metabolism, 87(11), 5185-5190.
49. Olea, N., Pulgar, R., Pérez, P., Olea-Serrano, F., Rivas, A., Novillo-Fertrell, A., Sonnenschein, C. vd. (1996). Estrogenicity of resin-based composites and sealants used in dentistry. Environmental health perspectives, 104(3), 298-305.
50. Otlu, H. G., & Türköz, Y. (2016). Bisphenol A Exposure Routes Metabolism and Toxicity..
51. Öz E. Bisfenol A’nın HEPG2 Hücrelerine Olan Etkilerinin İncelenmesi. Hacettepe Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, 2020, Ankara (Danışman: Doç. Dr. Z.Tuba Tüylü Küçükkılınç)
52. Papalou, O., Kandaraki, E. A., Papadakis, G., & Diamanti-Kandarakis, E. (2019). Endocrine disrupting chemicals: an occult mediator of metabolic disease. Frontiers in Endocrinology, 10, 112.
53. Park, M. A., & Choi, K. C. (2014). Effects of 4-nonylphenol and bisphenol A on stimulation of cell growth via disruption of the transforming growth factor-β signaling pathway in ovarian cancer models. Chemical research in toxicology, 27(1), 119-128.
54. Seiwa, C., Nakahara, J., Komiyama, T., Katsu, Y., Iguchi, T., & Asou, H. (2004). Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells. Neuroendocrinology, 80(1), 21-30.
55. Sevencan, F., & Vaizoğlu, S. A. (2007). Pet ve geri dönüşümü. TSK Koruyucu Hekimlik Bülteni, 6(4), 307-312.
56. Shelby, M. D. (2008). NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. Ntp cerhr mon, (22), v.
57. Snyder, R. W., Maness, S. C., Gaido, K. W., Welsch, F., Sumner, S. C., & Fennell, T. R. (2000). Metabolism and disposition of bisphenol A in female rats. Toxicology and applied pharmacology, 168(3), 225-234.
58. Soto, A. M., & Sonnenschein, C. (2010). Environmental causes of cancer: endocrine disruptors as carcinogens. Nature Reviews Endocrinology, 6(7), 363-370.
59. Sözlü, S., & Akdevelioğlu, Y. (2018). Bisfenol A (BFA) ve insan üreme sağlığı. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 11(1), 86-99.
60. Stahlhut, R. W., Welshons, W. V., & Swan, S. H. (2009). Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both. Environmental health perspectives, 117(5), 784-789.
61. Sun, H., Shen, O. X., Wang, X. R., Zhou, L., Zhen, S. Q., & Chen, X. D. (2009). Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay. Toxicology in vitro, 23(5), 950-954.
62. Ustundag, U. V., İsmail, U. N. A. L., Ates, P. S., Alturfan, A. A., Yigitbasi, T., & Alturfan, E. E. (2017). Oxidant-Antioxidant Status and c-myc Expression in BFA-and DEHP-Exposed Zebrafish Embryos. European Journal of Biology, 76(1), 26-30.
63. Ünlügenç, E., & Bolgül, B. (2019). Güncel Fissür Örtücüler–Literatür Derlemesi. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 30(3), 507-518.
64. Üstündağ, Ü. V., Ünal, İ., Ateş, P. S., Alturfan, A. A., Yiğitbaşı, T., & Emekli-Alturfan, E. (2017). Bisphenol A and di (2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/β-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action. Toxicology and industrial health, 33(12), 901-910.
65. Vandenberg, L. N., Chahoud, I., Heindel, J. J., Padmanabhan, V., Paumgartten, F. J., & Schoenfelder, G. (2010). Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environmental health perspectives, 118(8), 1055-1070.
66. Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs Jr, D. R., Lee, D. H., Zoeller, R. T. vd. (2012). Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocrine reviews, 33(3), 378-455.
67. Vandenberg, L. N., Hunt, P. A., Myers, J. P., & vom Saal, F. S. (2013). Human exposures to bisphenol A: mismatches between data and assumptions. Reviews on environmental health, 28(1), 37-58.
68. Vandenberg, L. N., Maffini, M. V., Sonnenschein, C., Rubin, B. S., & Soto, A. M. (2009). Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocrine reviews, 30(1), 75-95.
69. Veiga-Lopez, A., Kannan, K., Liao, C., Ye, W., Domino, S. E., & Padmanabhan, V. (2015). Gender-specific effects on gestational length and birth weight by early pregnancy BFA exposure. The Journal of Clinical Endocrinology & Metabolism, 100(11), E1394-E1403.
70. Vom Saal, F. S., VandeVoort, C. A., Taylor, J. A., Welshons, W. V., Toutain, P. L., & Hunt, P. A. (2014). Bisphenol A (BFA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures. Reproductive Toxicology, 45, 105-116.
71. Welshons, W. V., Nagel, S. C., & vom Saal, F. S. (2006). Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology, 147(6), s56-s69.
72. Willhite, C. C., Ball, G. L., & McLellan, C. J. (2008). Derivation of a bisphenol A oral reference dose (RfD) and drinking-water equivalent concentration. Journal of Toxicology and Environmental Health, Part B, 11(2), 69-146.
73. Wioletta, R. W., Małgorzata, R., Karolina, N., Milena, D., Piotr, R., & Ewa, J. (2020). Effect of bisphenol A on human neutrophils immunophenotype. Scientific Reports (Nature Publisher Group), 10(1).
74. Yaman, Ü., Erkekoğlu, P., & Gümüşel, B. K. Endokrin Bozucu Kimyasal Maddeler ve Tiroid Üzerine Etkileri: Poliklorlu Bifeniller, Ftalat ve Bisfenol A. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, (1), 1-19.
75. Ye, X., Pierik, F. H., Angerer, J., Meltzer, H. M., Jaddoe, V. W., Tiemeier, H., Longnecker, M. P. vd. (2009). Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). International journal of hygiene and environmental health, 212(5), 481-491.
76. Ye, X., Pierik, F. H., Hauser, R., Duty, S., Angerer, J., Park, M. M., Steegers, E. A. vd. (2008). Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study. Environmental research, 108(2), 260-267.
77. Ye, X., Wong, L. Y., Bishop, A. M., & Calafat, A. M. (2011). Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections. Environmental health perspectives, 119(7), 983-988.
78. ZEMHERİ, F., & Cevdet, U. Ğ. U. Z. (2018). Endokrin bozucu kimyasallar: Nonilfenol ve Bisfenol A. Marmara Fen Bilimleri Dergisi, 30(1), 71-76.
79. Zoeller, R. T. (2005). Environmental chemicals as thyroid hormone analogues: new studies indicate that thyroid hormone receptors are targets of industrial chemicals?. Molecular and cellular endocrinology, 242(1-2), 10-15.
80. Zoeller, R. T., Bansal, R., & Parris, C. (2005). Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain. Endocrinology, 146(2), 607-612.
81. Zoeller, R. T., Brown, T. R., Doan, L. L., Gore, A. C., Skakkebaek, N. E., Soto, A. M., Vom Saal, F. S. vd. (2012). Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology, 153(9), 4097-4110.