Antihipertansif İlaçların Dental İmplant Stabilitesi ve İmplant Çevresi Sağlığı Üzerindeki Etkisi: Retrospektif Kohort Çalışması

Abstract

Amaç: Bu çalışmanın amacı, antihipertansif ilaç kullanan bireyler ile normotansif bireyler arasında implant stabilitesini (rezonans frekans analizi ile ölçülen) ve klinik parametreleri (sondalamada kanama ve radyografik kemik kaybı) karşılaştırmaktır. Materyal ve Metot: Retrospektif kohort tasarımı ile gerçekleştirilen bu çalışmaya toplam 265 implant yerleştirilen 50 katılımcı dahil edilmiştir. Primer (ISQ-1) ve sekonder (ISQ-2) stabilite için RFA ölçümleri yapılmış ve klinik parametreler değerlendirilmiştir. Kohort, antihipertansif ilaç kullananlar ve normotansif bireyler olmak üzere iki gruba ayrılmıştır. Bulgular: Antihipertansif kullanan bireylerde ISQ-1 (ortalama: 78.9, SD: 6.0) ve ISQ-2 (ortalama: 82.9, SD: 4.6) değerleri kontrol grubuna kıyasla (ISQ-1 ortalama: 72.3, SD: 5.2; ISQ-2 ortalama: 80.4, SD: 3.9) anlamlı derecede yüksekti (p<0.001). Sondalamada kanama oranı antihipertansif kullanan grupta daha yüksek (%25.9) bulunurken, kontrol grubunda bu oran %22.4 olarak tespit edilmiştir (p<0.001). Radyografik kemik kaybı açısından ise gruplar arasında anlamlı bir fark bulunmamıştır (antihipertansif: 0.99 mm, SD: 0.7; kontrol: 0.96 mm, SD: 0.5; p=0.733). Sonuç: Antihipertansif ilaç kullanan bireylerde implant stabilitesi daha yüksek bulunmuş olup, bu ilaçların osseointegrasyon süreci üzerinde olumlu etkileri olabileceği düşünülmektedir. Ancak, sondalamada kanama oranındaki artış peri-implant inflamasyon riskine işaret edebilir. Daha geniş örneklemlerle prospektif çalışmalar yapılması önerilmektedir.

Keywords

• Antihipertansif İlaçlar
• Diş İmplantları
• Kemik Yoğunluğu
• Hipertansiyon
• Osseointegrasyon

Effect of Antihypertensive Drugs on Dental Implant Stability and Peri-Implant Health: Retrospective Cohort Study

Abstract

Objective: The aim of this study was to compare implant stability (measured by resonance frequency analysis) and clinical parameters (bleeding on probing and radiographic bone loss) between individuals using antihypertensive medication and normotensive individuals. Materials and Methods: A total of 265 50 participants who received implants were included. RFA measurements were performed for primary (ISQ-1) and secondary (ISQ-2) stability and clinical parameters were evaluated. The cohort was divided into two groups: those using antihypertensive drugs and normotensive individuals. Results: ISQ-1 in individuals using antihypertensive drugs (mean: 78.9, SD: 6.0) and ISQ-2 (mean: 82.9, SD: 4.6) values were significantly higher compared to the control group (ISQ-1 mean: 72.3, SD: 5.2; ISQ-2 mean: 80.4, SD: 3.9) (p< The rate of bleeding on probing was found to be higher in the antihypertensive group (25.9%), while this rate was found to be 22.4% in the control group (p<0.001). There was no significant difference between the groups in terms of radiographic bone loss (antihypertensive: 0.99 mm, SD: 0.7; control: 0.96 mm, SD: 0.5; p=0.733). Conclusion: Implant stability was found to be higher in individuals using antihypertensive drugs, and It is thought that it may have positive effects on the osseointegration process. However, an increase in the rate of bleeding on probing may indicate a risk of peri-implant inflammation. Prospective studies with larger samples are recommended.

Keywords

• Antihypertensive Agents
• Dental Implants
• Bone Density
• Hypertension
• Osseointegration

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