Erzincan University Journal of Science and Technology 2149-4584 Erzincan Binali Yıldırım Üniversitesi 10.18185/erzifbed.1555393 Pharmaceutical Biochemistry Eczacılık Biyokimyası Radioprotective effect of Umbelliferon Against Radiation-Induced Myocardial Damages https://orcid.org/0009-0009-1658-6484 Dumlu Nurdan https://orcid.org/0000-0003-2488-1757 Geyikoğlu Fatime Atatürk üniversitesi https://orcid.org/0000-0001-8320-3038 Çolak Suat ECZACILIK FAKÜLTESİ 12 31 2024 17 3 811 825 09 24 2024 11 01 2024 Copyright © 2008, Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 2008 Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

Radiation at a high dose may attenuate myocardial functions while presenting the therapeutic effect on cancer cells and thus can be life-threatening. Today, many studies reveal that supportive treatments provide important protective effects against acute radiation damage in vital organs including the heart. To our knowledge, the role of umbelliferone in the prevention of radiation damage to the heart has not yet been clarified. Therefore, the current study was planned to evaluate the role of umbelliferone radiation-induced cardiac injury using biochemical and histological data. Rats will be divided into eight different groups as control, radiation and treatment groups. No application was made to the control group. The second group animals were exposed to a single dose (12Gy) radiation throughout the body. Groups 3, 4 and 5 were orally given umbelliferone (25, 50 and 100 mg/kg) single dose for 3 days. Groups 6, 7 and 8 received umbelliferone and then radiation was applied. After the experiments, the myocardial tissues of the rats were removed and the protection of the substance against radiation was investigated. Radiation exposure to the rats induced oxidative stress, inflammation, pathological changes and vascular dysfunction in cardiac tissue. Whereas umbelliferone in high dose (100 mg/kg) pretreatment supported the anti-oxidant activity and also reduced the inflammatory response on heart tissue against radiation-associated toxicity. Besides, radiation-induced histopathological changes significantly ameliorated in umbelliferone-treated rat groups. Umbelliferone (100 mg/kg) pretreatment reduced radiation-induced heart damage, which was thought to provide the greatest opportunity for umbelliferone's efficacy as a new drug against the side effects of radiotherapy

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