HARNESSING GOLD NANORODS FOR NON-ENZYMATIC GLUCOSE SENSING

Yıl 2023, Cilt: 24 Sayı: 4 - Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering, 300 - 308, 27.12.2023

Zeliha Cansu Canbek Ozdil

https://doi.org/10.18038/estubtda.1330450

Öz

This study presents a straightforward and non-enzymatic approach for glucose detection utilizing aggregated gold nanorods (GNRs) based on surface plasmon resonance (SPR). The GNRs exhibited enhanced sensitivity toward glucose concentrations of up to 10 mM. The LSPR-based glucose detection method demonstrated superior sensitivity, stability, ease of use, and a convenient readout. Moreover, the LSPR detection technique can be seamlessly integrated with various sensing platforms, offering the potential to expand the sensor's range and applicability. This study highlights the promising prospects of LSPR-based non-enzymatic glucose detection and its potential for integration into diverse sensing systems. For the 10 mM glucose solution, the addition of 5.85x109 GNRs caused a 136 nm shift. On the other hand, when 50 mM glucose is added, the shift amounted to 82 nm, while adding 100 mM glucose resulted in a shift of 71 nm. This implies that at lower glucose concentrations, the degree of aggregation is greater, suggesting a heightened sensitivity to smaller concentrations. TEM images depicted the formation of the gold nanorod aggregates upon the introduction of 10 mM glucose.

Anahtar Kelimeler

Gold nanorods, Non-enzymatic glucose sensing, Nanosensor

Destekleyen Kurum

Boğaziçi Üniversitesi

Proje Numarası

19A01P1

Kaynakça

• [1] Cao J, Sun T, Kenneth T, Grattan V. Development of gold nanorod-based localized surface plasmon resonance optical fiber biosensor. 22nd International Conference on Optical Fiber Sensors, 2012; p 8421.
• [2] Saeed AA, Sánchez JLA, O’Sullivan CK, Abbas MN. DNA biosensors based on gold nanoparticles-modified graphene oxide for the detection of breast cancer biomarkers for early diagnosis. Bioelectrochemistry. 2017; 118, 91-99.
• [3] Xu M, Song Y, Ye Y, et al. A novel flexible electrochemical glucose sensor based on gold nanoparticles/polyaniline arrays/carbon cloth electrode. Sensors and Actuators B: Chemical. 2017; 252, 1187-1193.
• [4] Hu M, Chen J, Li ZY, et al. Gold nanostructures: engineering their plasmonic properties for biomedical applications. Chem Soc Rev. 2006; 35 (11), 1084-1094.
• [5 ] Kelly KL, Coronado E, Zhao LL, Schatz GC. The Optical Properties of Metal Nanoparticles:  The Influence of Size, Shape, and Dielectric Environment. J Phys Chem B. 2002; 107 (3), 668-677.
• [6] Lohse SE, Murphy CJ. The Quest for Shape Control: A History of Gold Nanorod Synthesis. Chem Mater. 2013; 25(8), 1250-1261.
• [7] Huang X, Neretina S, El-Sayed MA. Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications. Advanced Materials. 2009; 21 (48), 4880-4910.
• [8] Elechiguerra JL, Reyes-Gasga J, Yacaman MJ. The role of twinning in shape evolution of anisotropic noble metal nanostructures. J Mater Chem. 2006; 16 (40), 3906-3919.
• [9] Ramadoss R. MEMS devices for biomedical applications. Solid State Technology. Published online 2013. https://electroiq.com/2013/10/mems-devices-for-biomedical-applications/.
• [10] Scarabelli L, Coronado-Puchau M, Giner-Casares JJ, Langer J, Liz-Marzán LM. Monodisperse Gold Nanotriangles: Size Control, Large-Scale Self-Assembly, and Performance in Surface-Enhanced Raman Scattering. ACS Nano. 2014; 8, p 5833.
• [11] Jana NR. Nanorod Shape Separation Using Surfactant Assisted Self-Assembly. Chem Commun. 2003;15, p 1950.
• [12] Scarabelli L, Sánchez-Iglesias A, Pérez-Juste J, Liz-Marzán LM. A “Tips and Tricks” Practical Guide to the Synthesis of Gold Nanorods. J Phys Chem Lett. 2015; 6 (21), 4270-4279.
• [13] Lin Y, Zhao M, Guo Y, et al. Multicolor Colormetric Biosensor for the Determination of Glucose based on the Etching of Gold Nanorods. Scientific Reports. 2016; 6 (1), p 37879.
• [14] Chen KC, Li YL, Wu CW, Chiang CC. Glucose Sensor Using U-Shaped Optical Fiber Probe with Gold Nanoparticles and Glucose Oxidase. Sensors (Basel). 2018; 18 (4), p 1217.
• [15] Yin B, Zheng W, Dong M, et al. An enzyme-mediated competitive colorimetric sensor based on Au@Ag bimetallic nanoparticles for highly sensitive detection of disease biomarkers. Analyst. 2017; 142 (16), 2954-2960.
• [16] Tao Y, Luo F, Lin Y, Dong N, Li C, Lin Z. Quantitative gold nanorods based photothermal biosensor for glucose using a thermometer as readout. Talanta. 2021; 230, p 122364.
• [17] Peng CA, Pachpinde S. Longitudinal Plasmonic Detection of Glucose Using Gold Nanorods. Nanomaterials and Nanotechnology. 2014; 4, p 9.
• [18] Xianyu Y, Sun J, Li Y, Tian Y, Wang Z, Jiang X. An ultrasensitive, non-enzymatic glucose assay via gold nanorod-assisted generation of silver nanoparticles. Nanoscale. 2013; 5 (14): 6303-6306.
• [19] Nikoobakht B, El-Sayed MA. Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method. Chem Mater. 2003; 15, p 1957.
• [20] Brioude A, Jiang XC, Pileni MP. Optical Properties of Gold Nanorods:  DDA Simulations Supported by Experiments. J Phys Chem B. 2005; 109(27), 13138-13142.