etd Ege Tıp Dergisi 1016-9113 2147-6500 Ege Üniversitesi 10.19161/etd.465086 Health Care Administration Sağlık Kurumları Yönetimi Coronary artery calcium score is associated with red blood cell distribution width and mean platelet volume Koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ve ortalama trombosit hacmi ile ilişkilidir https://orcid.org/0000-0002-3996-5681 Altın Cihan Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir https://orcid.org/0000-0002-2557-9579 Yılmaz Mustafa Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Adana https://orcid.org/0000-0002-1001-6028 Gezmiş Esin Başkent Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, İzmir https://orcid.org/0000-0002-9635-6313 Müderrisoğlu Haldun Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara 09 20 2019 58 3 222 228 04 20 2018 07 06 2018 Copyright © 1962, Ege Tıp Dergisi 1962 Ege Tıp Dergisi

Aim: In this paper, itis aimed to investigate red blood celldistribution width (RDW), mean platelet volume (MPV) and coronary arterycalcium scores (CACS) in patients with and without coronary artery disease(CAD) detected by coronary computed tomography angiography (CCTA).Materials and Methods: Clinicalrecords of 172 patients who underwent CCTA due to the presence of angina-likesymptoms were retrospectively investigated. Clinical characteristics, riskfactors for CAD, CACS and biochemical parameters including RDW and MPV wererecorded.Results: Mean MPV (7.95 ±1.57 fL vs.7.12±1.26 fL, p<0.001) and RDW (15.36±1.15% vs 14.37±2.01%; p<0.001)levels were significantly higher in patients with CAD (n=85) than in those withnormal coronary arteries (n=87). CACS is positively corralated with age(r=0.339, p<0.001), fasting glucose (r=0.223, p=0.003), C-reactive protein(r=0.294, p<0.001), RDW (r=0.157, p=0.04) and MPV (r=0.221, p=0.004). Onmultivariate logistic regression analysis, CACS [odds ratio (OR): 1.005; 95%confidence interval (CI): 1.002-1.008; p=0.001] and MPV [OR: 1.410; 95% CI:1.069-1.860; p=0.015] were shown to be one of the independent predictors forCAD detected by CCTA.Conclusion: RDW andMPV were increased in patients with CAD detected by CCTA. These parameters werepossitively corralated with CACS which is a well-known indicator for CAD.Because several factors may affect these parameters further prospective studiesare needed to confirm our results.

Amaç: Bu çalışmada, koroner bilgisayarlıtomografik anjiyografi (KBTA) ile saptanan koroner arter hastalığı (KAH) vekoroner arter kalsiyum skorunun (KAKS) kırmızı kan hücresi dağılım genişliği(RDW) ve ortalama trombosit hacmi (MPV) arasındaki ilişkinin değerlendirilmesi amaçlandı.Gereç ve Yöntem: Anjina veya benzeri semptomlar nedeniyle 64 kesitli KBTA uygulanan 172hastanın tıbbi kayıtları geriye dönük olarak incelendi. Hastaların kliniközellikleri, risk faktörleri, KAKS’ı da içeren KBTA sonuçları, RDW, MPVdeğerlerini de içeren biyokimyasal ve hematolojik parametreleri kaydedildi.Bulgular: Çalışma popülasyonu KBTA sonuçlarına göre KAH (n=85) ve normal koronerarter (NKA) (n=87) olmak üzere iki gruba ayrıldı. Ortalama RDW (%15,36±1,15’ekarşı %14,37±2,01; p<0,001) ve MPV (7,95 ± 1,57 fL’e karşı 7,12±1,26 fL,p<0,001) seviyeleri KAH grubunda NKA grubuna göre anlamlı olarak yükseksaptandı. KAKS ile yaş (r=0,339, p<0,001), açlık kan şekeri (r=0,223, p=0,003),C-reaktif protein (r=0,294, p<0,001), RDW (r=0,157, p=0,04) ve MPV (r=0,221,p=0,004) arasında pozitif korelasyon saptandı. Yapılan çok değişkenli lojistikregresyon analizinde KAKS [odds oranı (OR): 1,005; %95 güven aralığı (CI): 1,002-1,008;p=0,001] ve MPV [OR: 1,410; %95 CI: 1,069-1.860; p=0.015] KBTA ile saptananKAH’ın bağımsız risk faktörleri arasında saptandı.Sonuç: RDW ve MPV KAH grubunda anlamlı olarak daha yüksek saptanmıştır. Koroneraterosklerozun iyi bir göstergesi olan KAKS ile bu parametreler arasındapozitif bir korelasyon gösterilmiştir. MPV ve RDW düzeylerinin çok çeşitlifaktörlerden etkilenebileceği de düşünülürse bu konuda geniş kapsamlı ileri prospektifçalışmalara ihtiyaç duyulmaktadır.

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