etd Ege Tıp Dergisi 1016-9113 2147-6500 Ege Üniversitesi 10.19161/etd.648528 Health Care Administration Sağlık Kurumları Yönetimi Biyolojik ajanların pulmoner komplikasyonları Pulmonary complications of biological agents https://orcid.org/0000-0003-4507-9851 Taşbakan M. Sezai Ege Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı 10 25 2019 13 14 10 19 2018 08 15 2019 Copyright © 1962, Ege Tıp Dergisi 1962 Ege Tıp Dergisi

İnflamatuvar romatolojik hastalıklarda biyolojik ajanların kullanımı ile ilgili veri sayısı artmaktadır. Son zamanlarda, biyolojik ajanlarla ilişkili non-enfeksiyöz komplikasyonlar arasında en sık granülomatöz hastalık ve interstisyel akciğer hastalığı görülmektedir. Ek olarak, bu ilaçlarla ilişkili en ciddi yan etkiler bakteriyel pnömoni gibi solunum sistemi enfeksiyonları, tüberküloz ve Pneumocystis jirovecii pnömonisidir. Özellikle, tümör nekroz faktör-alfa (TNF-α) gibi biyolojik ajanlar ile yapılan tedaviler artmış tüberküloz riski ile ilişkilidir. Bu ilaçları alan hastalarda tüberküloz taraması ve latent tüberküloz tedavisi yapılması bu nedenle endikedir

There are increasing data available about use of biologic agents in treatment of systemic inflammatory rheumatologic disorders. Currently reported noninfectious pulmonary complications related to biologic agents use include most commonly granulomatous disease and interstitial lung disease. In addition, the most serious adverse events from these drugs are respiratory infections, especially bacterial pneumonia, tuberculosis, and Pneumocystis jirovecii pneumonia. Treatment with biologic agents, in particular tumor necrosis factor alpha (TNF-α) inhibitors, is associated with an increased risk of tuberculosis. Screening and treatment for latent tuberculosis infection in patients undergoing such treatment is therefore indicated

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