etd Ege Tıp Dergisi 1016-9113 2147-6500 Ege Üniversitesi 10.19161/etd.648718 Health Care Administration Sağlık Kurumları Yönetimi Hastalığı modifiye eden antiromatizmal ilaçlarla etkileşimler bakımından analjezik ilaçların akılcı kullanımı Rational use of analgesics with regard to the interactions with disease-modifying anti-rheumatic drugs https://orcid.org/0000-0002-7273-1131 Önal Aytül Ege Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı 10 25 2019 27 33 10 19 2019 08 15 2019 Copyright © 1962, Ege Tıp Dergisi 1962 Ege Tıp Dergisi

İnflamatuar nitelikli romatizmal hastalıklarda, analjezikler özellikle de NSAİİ’ler “Hastalığı modifiye eden antiromatizmal ilaçlar (Disease-Modifying Anti-Rheumatic drugs; DMARDs)” ile birlikte sıklıkla kullanılan ilaçlardandır. Söz konusu ilaçlar arasındaki etkileşimler ile ilgili yapılmış kontrollü çalışmalar çok değildir ve daha çok metotreksat ve NSAİİ’ler arasındaki etkileşimler ile ilgilidir. Özellikle son yıllarda kullanımı artan biyolojik DMARD’ler ile analjezik ilaçlar arasındaki etkileşmelere yönelik kontrollü araştırmalara büyük ihtiyaç vardır. Derlememizde, DMARD’ler ile analjezik ilaçlar arasındaki etkileşimler bakımından akılcı ilaç kullanımından söz edilmiştir. Bu etkileşimler, proteine bağlanma, renal, gastrointestinal, hematolojik, hepatik fonksiyonlar ve enzim düzeyindeki değişimler ile ilgili alt başlıklar şeklinde sunulmuştur.

In the inflammatory rheumatic diseases, analgesics, especially the NSAIDs are the most used drugs with the disease-modifying anti-rheumatic drugs (DMARDs). The controlled studies which were done related with the interactions between the aforementioned drugs are not too many and they are more related with interactions between methotrexate and NSAIDs. Controlled studies are mostly needed related with the interactions between analgesic drugs and biologic DMARDs which were especially came into use in the recent years. In our review, rational use of drugs was mentioned with regard to the interaction between DMARDs and analgesic drugs. These interactions were presented as subtitles related with changes in binding to proteins, renal, gastrointestinal system, hematologic, hepatic functions and the levels of enzymes.

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