etd

Ege Tıp Dergisi

1016-9113 2147-6500

Ege Üniversitesi

10.19161/etd.648954

Inflammatory myositis: Idiopathic? Overlap? Paraneoplastic?

İnflamatuar miyozitler: İdiyopatik mi? Çakışma mı? Paraneoplastik mi?

https://orcid.org/0000-0001-8347-0873

Can

Gerçek

Dokuz Eylül Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı

10 25 2019

51 57 10 19 2018 08 15 2019

1962

Ege Tıp Dergisi

Inflammatory myositis is a heterogeneous group of diseases, mainly involving muscle inflammation, where extramuscular lesions such as the skin, lung, heart, and gastrointestinal tract can be involved. It is characterized by proximal muscle weakness, elevated muscle enzyme, myopathic pattern in electromyography, typical histological findings in muscle biopsy and typical skin lesions in dermatomyositis. Inflammatory myositis can be divided into subgroups, including dermatomyositis, immune-mediated necrotizing myopathy, overlap myositis (containing antisynthetase syndrome), inclusion body myositis, amyopathic dermatomyositis, polymyositis, cancer-associated myositis through new myositis specific autoantibodies, histopathological developments, and classification criteria.

İnflamatuar miyozitler temel olarak kas inflamasyonu ile karakterize, bunun yanında cilt, akciğer, kalp, gastrointestinal sistem gibi ekstramusküler tutulum yapabilen heterojen bir grup hastalıktır. Proksimal kas güçsüzlüğü, kas enzim yüksekliği, elektromiyografide miyopatik patern, kas biyopsisinde tipik histolojik bulgular, dermatomiyozitte tipik deri lezyonları ile karakterizedir. İnflamatuar miyozitler, yeni miyozit spesifik otoantikorlar, histopatolojik gelişmeler, sınıflandırma kriterlerinin ışığında; dermatomiyozit, immün aracılı nekrotizan miyopati, overlap miyozit (antisentetaz sendromunu içeren), sporodik inklüzyon cisimcikli miyozit, amiyopatik dermatomiyozit, polimiyozit, kanser ilişkili miyozit olmak üzere alt gruplara ayrılabilir

İdiyopatik inflamatuvar miyozitler inflamatuar miyozit alt tipleri miyozit spesifik otoantikorlar miyozit sınıflandırma kriterleri

Idiopathic inflammatory myositis subgroups myositis-specific autoantibodies classification criteria

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