Postmenopozal Kadınlarda Hiperlipideminin Mamografi Sonuçları Üzerindeki Etkisi

Yıl 2024, , 124 - 130, 06.11.2024

Fahri Burçin Fıratlıgil , Belgin Savran Üçok , Erkan Sağlam , Yıldız Akdaş Reis , Yaprak Ustun

https://doi.org/10.46969/EZH.1561035

Öz

Amaç: Postmenopozal kadınlarda hiperlipideminin mamografi ile saptanabilen spesifik veya nonspesifik değişikliklere neden olup olmadığını belirlemek.
Gereç ve Yöntem: Bu çalışma Ocak 2017-Ocak 2020 tarihleri arasında Etlik Zübeyde Hanım Kadın Sağlığı Eğitim ve Araştırma Hastanesi jinekoloji kliniklerinde retrospektif olarak yürütülmüş ve vaka-kontrol çalışması olarak tasarlanmıştır. Polikliniklerimizde muayene olan ve mamografik kontrolleri hastanemizde gerçekleşen, total kolesterol (TC) düzeyi 200 mg/dL ve 200 mg/dL’nin üzerinde olan sağlıklı postmenopozal kadınlar çalışma grubuna (Grup I) dahil edildi. Aynı klinikte takip edilen ve mamografik kontrolleri kliniğimizde yapılan sağlıklı postmenopozal kadınlardan TC düzeyi 200 mg/dL’nin altında olanlar kontrol grubuna (Grup II) dahil edildi. Mamografi bulguları ile TC, düşük yoğunluklu lipoprotein kolesterol, çok düşük yoğunluklu lipoprotein kolesterol, yüksek yoğunluklu lipoprotein kolesterol ve trigliseridler analiz edildi.
Bulgular: Gruplar arasında yaş ve vücut kitle indeksi açısından anlamlı bir fark yoktu. Sigara içme durumu ve ailede meme kanseri öyküsü arasında anlamlı bir fark bulunmamıştır. BAC ve BI-RADS skorlama kategorileri değerleri arasında anlamlı fark vardı (sırasıyla p=0.006 vs p=0.042)
Sonuç: Hiperlipidemisi olan postmenopozal kadınlar meme kanserine yol açabilecek mamografik bulgulara sahiptir. Hiperlipideminin hipertansiyon, diabetes mellitus ve kardiyovasküler hastalık gibi başka morbidite ve mortalite nedenleri de olabileceği düşünüldüğünde, yaşam tarzı değişiklikleri ve/veya ilaç tedavisi ile tedavi edilmesi gerekmektedir. Bu çalışma sınırlı sayıda hastayı içeren retrospektif bir çalışma olduğundan, gelecekte yapılacak randomize kontrollü çalışmaların bu konuda daha güvenilir veriler sağlayabileceği açıktır.

Anahtar Kelimeler

meme kanseri, hiperlipidemi, mamografi, post-menopoz

The Influence of Hyperlipidemia on the Results of Mammography in Postmenopausal Women

Öz

Aim: To determine whether hyperlipidemia causes specific or nonspecific changes that can be detected by mammography in postmenopausal women.
Materials and Method: This study was conducted retrospectively and designed as a case-control study in the gynecology clinics of Etlik Zubeyde Hanim Women’s Health Education and Training Hospital between January 2017 and January 2020. Healthy postmenopausal women with a total cholesterol (TC) level of 200 mg/dL and above 200 mg/dL, who were examined in our outpatient clinics and whose mammographic controls were performed in our hospital, were included in the study group (Group I). Healthy postmenopausal women with a TC level below 200 mg/dL who were followed up at the same clinic and whose mammographic controls were performed at our clinic were included in the control group (Group II). We analyzed TC, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides with mammography findings.
Results: There were no significant differences between the groups in terms of age and body mass index. There were no significant differences between smoking status and family history of breast cancer. The BAC and BI-RADS scoring category scores differed significantly (p=0.006 and p=0.042, respectively).
Conclusion: Postmenopausal women with hyperlipidemia have mammographic findings that can lead to breast cancer. Considering that hyperlipidemia may also have other causes of morbidity and mortality, such as hypertension, diabetes mellitus and cardiovascular disease, it is necessary to treat it with lifestyle changes and / or medications. As this was a retrospective study with a limited number of patients, it is clear that future randomized controlled trials could provide more reliable data on this topic.

Anahtar Kelimeler

breast cancer, hyperlipidemia, mammography, post-menopause

Etik Beyan

This study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the local ethics committee (with number: 01/08; January 2022).

Destekleyen Kurum

None.

Teşekkür

None.

Kaynakça

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