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Bir Yenidoğanda Tekrarlayan Intravenöz Immünoglobulin ve Eritrosit Transfüzyonu ile Tedavi Edilen Anti-E, C ve Kell İzoimmünizasyonuna Bağlı Ciddi Hemolitik Hastalık

Yıl 2022, Cilt: 4 Sayı: 2, 97 - 99, 30.06.2022
https://doi.org/10.46969/EZH.1081460

Öz

Yenidoğanın alloimmün hemolitik hastalığının (YHH) etiyolojisinde Rhesus D dışındaki antikorların önemi giderek artmaktadır. Anti E, c ve Kell antikorlarının birlikte olduğu YHH daha önce bildirilmemiştir. Bu olgu sunumunda ciddi hemolitik hastalık ve sarılık nedeni ile tekrarlayan intravenöz immunoglobulin (İVİG) ve eritrosit transfüzyonu ile tedavi edilen bir vakayı sunmak istedik. Erkek yenidoğana doğumdan sonra 2 ve 3. günde 1 gr/kg IVIG verildi. Eritrosit transfüzyonu 6. günde yapıldı. Postnatal 12. günde hemoliz bulgularının devam etmesi üzerine 3. doz İVİG 1 gr/kg dozunda verildi. Taburculuk sonrası 3. haftada hemoliz bulguları saptanmadı. Sonuç olarak hemoliz, anemi ve sarılık saptanan yenidoğanlarda nadir olsa da birden fazla subgrup uyuşmazlığının olması akla gelmelidir. Fototerapi, İVİG ve eritrosit transfüzyonu tedavi seçenekleri arasındadır.

Kaynakça

  • Referans1. De Alarcon PA, EJ. W. Neonatal Hematology. New York: Cambridge University Press; 2005.
  • Referans2. Moise KJ, Jr. Non-anti-D antibodies in red-cell alloimmunization. European journal of obstetrics, gynecology, and reproductive biology 2000; 92: 75-81. Referans3. Dajak S, Stefanovic V, Capkun V. Severe hemolytic disease of fetus and newborn caused by red blood cell antibodies undetected at first-trimester screening (CME). Transfusion 2011; 51: 1380-8.
  • Referans4. Westhoff CM. The Rh blood group system in review: a new face for the next decade. Transfusion 2004; 44: 1663-73.
  • Referans5. Eder AF. Update on HDFN: new information on long-standing controversies. Immunohematology / American Red Cross 2006; 22: 188-95.
  • Referans6. Babinszki A, Berkowitz RL. Haemolytic disease of the newborn caused by anti-c, anti-E and anti-Fya antibodies: report of five cases. Prenatal diagnosis 1999; 19: 533-6.
  • Referans7. Bashawri LA. A Case of Haemolytic Disease of the Newborn Due to Maternal Anti-E and Anti-c. Bahrain Medical Bulletin 2007; 29:
  • Referans8. Farnault L, Garcia-Meric P, Cortey A, Arnaud F. [Fetomaternal anti-RH3, -4 (anti-E and anti-c) rhesus isoimmunization: a case report]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2011; 18: 176-82.
  • Referans9. Gottstein R, Cooke RW. Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn. Archives of disease in childhood Fetal and neonatal edition 2003; 88: F6-10.
  • Referans10. Demirel G, Akar M, Celik IH, Erdeve O, Uras N, Oguz SS, et al. Single versus multiple dose intravenous immunoglobulin in combination with LED phototherapy in the treatment of ABO hemolytic disease in neonates. International journal of hematology 2011; 93: 700-3.
  • Referans11. Onesimo R, Rizzo D, Ruggiero A, Valentini P. Intravenous Immunoglobulin therapy for anti-E hemolytic disease in the newborn. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet 2010; 23: 1059-61.
  • Referans12. Karagol BS, Zenciroglu A, Okumus N, Karadag N, Dursun A, Hakan N. Hemolytic disease of the newborn caused by irregular blood subgroup (Kell, C, c, E, and e) incompatibilities: report of 106 cases at a tertiary-care centre. Am J Perinatol 2012; 29: 449-54.

A Neonate with Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization

Yıl 2022, Cilt: 4 Sayı: 2, 97 - 99, 30.06.2022
https://doi.org/10.46969/EZH.1081460

Öz

Maternal Ig-G type blood group antibodies other than Rhesus D (RhD) are an increasingly significant cause of alloimmune hemolytic disease of the newborn (HDN). Anti-E, c and Kell associated HDN has not been reported in the literature. We report first case report of this combination with severe hemolytic anemia and hyperbilirubinemia requiring repeated doses of intravenous immunoglobulin (IVIG) and erythrocyte transfusion. He received 1 g/kg IVIG therapy on postnatal day 2 and 3 because of hemolysis. Erythrocyte transfusion was performed on postnatal day 6. Third dose IVIG as 1 gr/kg was given because of ongoing hemolysis on postnatal day 12. Three weeks after discharge he had no hemolysis. In conclusion, isoimmunization due to combination of subgroup incompatibility such as anti-E, c and Kell should be considered in patients with hemolysis, anemia and jaundice although combination of these isoimmunization is rare. Phototherapy, IVIG and erythrocyte transfusion are treatment options.

Kaynakça

  • Referans1. De Alarcon PA, EJ. W. Neonatal Hematology. New York: Cambridge University Press; 2005.
  • Referans2. Moise KJ, Jr. Non-anti-D antibodies in red-cell alloimmunization. European journal of obstetrics, gynecology, and reproductive biology 2000; 92: 75-81. Referans3. Dajak S, Stefanovic V, Capkun V. Severe hemolytic disease of fetus and newborn caused by red blood cell antibodies undetected at first-trimester screening (CME). Transfusion 2011; 51: 1380-8.
  • Referans4. Westhoff CM. The Rh blood group system in review: a new face for the next decade. Transfusion 2004; 44: 1663-73.
  • Referans5. Eder AF. Update on HDFN: new information on long-standing controversies. Immunohematology / American Red Cross 2006; 22: 188-95.
  • Referans6. Babinszki A, Berkowitz RL. Haemolytic disease of the newborn caused by anti-c, anti-E and anti-Fya antibodies: report of five cases. Prenatal diagnosis 1999; 19: 533-6.
  • Referans7. Bashawri LA. A Case of Haemolytic Disease of the Newborn Due to Maternal Anti-E and Anti-c. Bahrain Medical Bulletin 2007; 29:
  • Referans8. Farnault L, Garcia-Meric P, Cortey A, Arnaud F. [Fetomaternal anti-RH3, -4 (anti-E and anti-c) rhesus isoimmunization: a case report]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2011; 18: 176-82.
  • Referans9. Gottstein R, Cooke RW. Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn. Archives of disease in childhood Fetal and neonatal edition 2003; 88: F6-10.
  • Referans10. Demirel G, Akar M, Celik IH, Erdeve O, Uras N, Oguz SS, et al. Single versus multiple dose intravenous immunoglobulin in combination with LED phototherapy in the treatment of ABO hemolytic disease in neonates. International journal of hematology 2011; 93: 700-3.
  • Referans11. Onesimo R, Rizzo D, Ruggiero A, Valentini P. Intravenous Immunoglobulin therapy for anti-E hemolytic disease in the newborn. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet 2010; 23: 1059-61.
  • Referans12. Karagol BS, Zenciroglu A, Okumus N, Karadag N, Dursun A, Hakan N. Hemolytic disease of the newborn caused by irregular blood subgroup (Kell, C, c, E, and e) incompatibilities: report of 106 cases at a tertiary-care centre. Am J Perinatol 2012; 29: 449-54.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk Sağlığı ve Hastalıkları
Bölüm Olgu Sunumu
Yazarlar

Hüsniye Yücel 0000-0002-7477-0302

İstemi Han Çelik 0000-0002-2952-8154

Ayşen Sumru Kavurt 0000-0003-0329-1846

Beyza Özcan 0000-0002-2834-5823

Semih Sandal 0000-0002-0790-7399

Ahmet Yağmur Baş 0000-0002-1329-2167

Nihal Demirel 0000-0003-2044-2212

Yayımlanma Tarihi 30 Haziran 2022
Kabul Tarihi 13 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 4 Sayı: 2

Kaynak Göster

APA Yücel, H., Çelik, İ. H., Kavurt, A. S., Özcan, B., vd. (2022). A Neonate with Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization. Türk Kadın Sağlığı Ve Neonatoloji Dergisi, 4(2), 97-99. https://doi.org/10.46969/EZH.1081460
AMA Yücel H, Çelik İH, Kavurt AS, Özcan B, Sandal S, Baş AY, Demirel N. A Neonate with Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization. Türk Kadın Sağlığı ve Neonatoloji Dergisi. Haziran 2022;4(2):97-99. doi:10.46969/EZH.1081460
Chicago Yücel, Hüsniye, İstemi Han Çelik, Ayşen Sumru Kavurt, Beyza Özcan, Semih Sandal, Ahmet Yağmur Baş, ve Nihal Demirel. “A Neonate With Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization”. Türk Kadın Sağlığı Ve Neonatoloji Dergisi 4, sy. 2 (Haziran 2022): 97-99. https://doi.org/10.46969/EZH.1081460.
EndNote Yücel H, Çelik İH, Kavurt AS, Özcan B, Sandal S, Baş AY, Demirel N (01 Haziran 2022) A Neonate with Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization. Türk Kadın Sağlığı ve Neonatoloji Dergisi 4 2 97–99.
IEEE H. Yücel, “A Neonate with Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization”, Türk Kadın Sağlığı ve Neonatoloji Dergisi, c. 4, sy. 2, ss. 97–99, 2022, doi: 10.46969/EZH.1081460.
ISNAD Yücel, Hüsniye vd. “A Neonate With Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization”. Türk Kadın Sağlığı ve Neonatoloji Dergisi 4/2 (Haziran 2022), 97-99. https://doi.org/10.46969/EZH.1081460.
JAMA Yücel H, Çelik İH, Kavurt AS, Özcan B, Sandal S, Baş AY, Demirel N. A Neonate with Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization. Türk Kadın Sağlığı ve Neonatoloji Dergisi. 2022;4:97–99.
MLA Yücel, Hüsniye vd. “A Neonate With Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization”. Türk Kadın Sağlığı Ve Neonatoloji Dergisi, c. 4, sy. 2, 2022, ss. 97-99, doi:10.46969/EZH.1081460.
Vancouver Yücel H, Çelik İH, Kavurt AS, Özcan B, Sandal S, Baş AY, Demirel N. A Neonate with Severe Hemolytic Disease Treated With Repeated Doses of Intravenous Immunoglobulin and Erythrocyte Transfusion Due to Anti-E, C and Kell Isoimmunization. Türk Kadın Sağlığı ve Neonatoloji Dergisi. 2022;4(2):97-9.