Postmenopozal Kadınlarda Hiperlipideminin Mamografi Sonuçları Üzerindeki Etkisi

Year 2024, Volume: 6 Issue: 4, 124 - 130, 06.11.2024

Fahri Burçin Fıratlıgil , Belgin Savran Üçok , Erkan Sağlam , Yıldız Akdaş Reis , Yaprak Ustun

https://doi.org/10.46969/EZH.1561035

Abstract

Amaç: Postmenopozal kadınlarda hiperlipideminin mamografi ile saptanabilen spesifik veya nonspesifik değişikliklere neden olup olmadığını belirlemek.
Gereç ve Yöntem: Bu çalışma Ocak 2017-Ocak 2020 tarihleri arasında Etlik Zübeyde Hanım Kadın Sağlığı Eğitim ve Araştırma Hastanesi jinekoloji kliniklerinde retrospektif olarak yürütülmüş ve vaka-kontrol çalışması olarak tasarlanmıştır. Polikliniklerimizde muayene olan ve mamografik kontrolleri hastanemizde gerçekleşen, total kolesterol (TC) düzeyi 200 mg/dL ve 200 mg/dL’nin üzerinde olan sağlıklı postmenopozal kadınlar çalışma grubuna (Grup I) dahil edildi. Aynı klinikte takip edilen ve mamografik kontrolleri kliniğimizde yapılan sağlıklı postmenopozal kadınlardan TC düzeyi 200 mg/dL’nin altında olanlar kontrol grubuna (Grup II) dahil edildi. Mamografi bulguları ile TC, düşük yoğunluklu lipoprotein kolesterol, çok düşük yoğunluklu lipoprotein kolesterol, yüksek yoğunluklu lipoprotein kolesterol ve trigliseridler analiz edildi.
Bulgular: Gruplar arasında yaş ve vücut kitle indeksi açısından anlamlı bir fark yoktu. Sigara içme durumu ve ailede meme kanseri öyküsü arasında anlamlı bir fark bulunmamıştır. BAC ve BI-RADS skorlama kategorileri değerleri arasında anlamlı fark vardı (sırasıyla p=0.006 vs p=0.042)
Sonuç: Hiperlipidemisi olan postmenopozal kadınlar meme kanserine yol açabilecek mamografik bulgulara sahiptir. Hiperlipideminin hipertansiyon, diabetes mellitus ve kardiyovasküler hastalık gibi başka morbidite ve mortalite nedenleri de olabileceği düşünüldüğünde, yaşam tarzı değişiklikleri ve/veya ilaç tedavisi ile tedavi edilmesi gerekmektedir. Bu çalışma sınırlı sayıda hastayı içeren retrospektif bir çalışma olduğundan, gelecekte yapılacak randomize kontrollü çalışmaların bu konuda daha güvenilir veriler sağlayabileceği açıktır.

Keywords

meme kanseri, hiperlipidemi, mamografi, post-menopoz

The Influence of Hyperlipidemia on the Results of Mammography in Postmenopausal Women

Abstract

Aim: To determine whether hyperlipidemia causes specific or nonspecific changes that can be detected by mammography in postmenopausal women.
Materials and Method: This study was conducted retrospectively and designed as a case-control study in the gynecology clinics of Etlik Zubeyde Hanim Women’s Health Education and Training Hospital between January 2017 and January 2020. Healthy postmenopausal women with a total cholesterol (TC) level of 200 mg/dL and above 200 mg/dL, who were examined in our outpatient clinics and whose mammographic controls were performed in our hospital, were included in the study group (Group I). Healthy postmenopausal women with a TC level below 200 mg/dL who were followed up at the same clinic and whose mammographic controls were performed at our clinic were included in the control group (Group II). We analyzed TC, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides with mammography findings.
Results: There were no significant differences between the groups in terms of age and body mass index. There were no significant differences between smoking status and family history of breast cancer. The BAC and BI-RADS scoring category scores differed significantly (p=0.006 and p=0.042, respectively).
Conclusion: Postmenopausal women with hyperlipidemia have mammographic findings that can lead to breast cancer. Considering that hyperlipidemia may also have other causes of morbidity and mortality, such as hypertension, diabetes mellitus and cardiovascular disease, it is necessary to treat it with lifestyle changes and / or medications. As this was a retrospective study with a limited number of patients, it is clear that future randomized controlled trials could provide more reliable data on this topic.

Keywords

breast cancer, hyperlipidemia, mammography, post-menopause

Ethical Statement

This study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the local ethics committee (with number: 01/08; January 2022).

Supporting Institution

None.

Thanks

None.

References

• Ivanova M, Porta FM, Giugliano F, et al. Breast Cancer with Brain Metastasis: Molecular Insights and Clinical Management. Genes (Basel). 2023;14(6):1160. https://doi.org/10.3390/genes14061160
• De Cicco P, Catani MV, Gasperi V, Sibilano M, Quaglietta M, Savini I. Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence. Nutrients. 2019;11(7):1514. https://doi.org/10.3390/nu11071514
• Kunkler IH, Williams LJ, Jack WJL, Cameron DA, Dixon JM. Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer. N Engl J Med. 2023;388(7):585-94. https://doi.org/10.1056/NEJMoa2207586
• Yilmaz Baran S, Dogan Durdag G, Alemdaroglu S, Aydın S, Celik H. Leuprolide Acetate Treatment for Ovarian Cysts in Breast Cancer Patients Under Tamoxifen Therapy. Gynecol Obstet Reprod Med. 2022;28(3):265-9. https://doi.org/10.21613/GORM.2022.1320
• Cancer Statistics Center. Available at: https://cancerstatisticscenter.cancer.org/#!/cancer-site/Breast (Accessed on May 4, 2024).
• Zare N, Haem E, Lankarani KB, Heydari ST, Barooti E. Breast cancer risk factors in a defined population: weighted logistic regression approach for rare events. J Breast Cancer. 2013;16(2):214-9. https://doi.org/10.4048/jbc.2013.16.2.214
• Sun YS, Zhao Z, Yang ZN, et al. Risk Factors and Preventions of Breast Cancer. Int J Biol Sci. 2017;13(11):1387-97. https://doi.org/10.7150/ijbs.21635
• Mourouti N, Kontogianni MD, Papavagelis C, Panagiotakos DB. Diet and breast cancer: a systematic review. Int J Food Sci Nutr. 2015;66(1):1-42. https://doi.org/10.3109/09637486.2014.950207
• Protani M, Coory M, Martin JH. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat. 2010;123(3):627-35. https://doi.org/10.1007/s10549-010-0990-0
• Adderley-Kelly B, Williams-Stephens E. The relationship between obesity and breast cancer. ABNF J. 2003;14(3):61-5.
• Schetz M, De Jong A, Deane AM, et al. Obesity in the critically ill: a narrative review. Intensive Care Med. 2019;45(6):757-69. https://doi.org/10.1007/s00134-019-05594-1
• Demographic and Health Survey 1998. Ankara, Turkey: Hacettepe University Institute of Population Studies; 1999.
• Wang J, John EM, Horn-Ross PL, Ingles SA. Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. Nutr Cancer. 2008;60(4):492-504. https://doi.org/10.1080/01635580801956485
• Huang Z, Hankinson SE, Colditz GA, et al. Dual effects of weight and weight gain on breast cancer risk. JAMA. 1997;278(17):1407-11.
• Saxena A, Waddell IC, Friesen RW, Michalski RT. Monckeberg medial calcific sclerosis mimicking malignant calcification pattern at mammography. J Clin Pathol. 2005;58(4):447-8.
• Kataoka M, Warren R, Luben R, et al. How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography? AJR Am J Roentgenol. 2006;187(1):73-80. https://doi.org/10.2214/AJR.05.0365
• Maas AH, van der Schouw YT, Mali WP, van der Graaf Y. Prevalence and determinants of breast arterial calcium in women at high risk of cardiovascular disease. Am J Cardiol. 2004;94(5):655-9. https://doi.org/10.1016/j.amjcard.2004.05.036
• Kemmeren JM, van Noord PA, Beijerinck D, Fracheboud J, Banga JD, van der Graaf Y. Arterial calcification found on breast cancer screening mammograms and cardiovascular mortality in women: The DOM Project. Am J Epidemiol. 1998;147(4):333-41. https://doi.org/10.1093/oxfordjournals.aje.a009455
• IBM Corp. Released 2020. IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY: IBM Corp.
• InformedHealth.org. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Overview: High cholesterol. [Updated 2022 Feb 7]. Available at: https://www.ncbi.nlm.nih.gov/books/NBK279318/
• Vallejo-Vaz AJ, Robertson M, Catapano AL, et al. Low-Density Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above: Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year Randomized Trial and 20-Year Observational Follow-Up. Circulation. 2017;136(20):1878-91. https://doi.org/10.1161/CIRCULATIONAHA.117.027966
• Torgutalp ŞŞ, Babayeva N, Taş S, Dönmez G, Korkusuz F. Effects of hyperlipidemia on patellar tendon stiffness: A shear wave elastography study. Clin Biomech (Bristol, Avon). 2020;75:104998. https://doi.org/10.1016/j.clinbiomech.2020.104998
• Squier K, Scott A, Hunt MA, et al. The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study. PLoS One. 2021;16(9):e0257269. https://doi.org/10.1371/journal.pone.0257269
• Bayrakçeken E, Yaralı S, Alkan Ö. Identify risk factors affecting participation of Turkish women in mammography screening for breast cancer prevention. Breast Cancer Res Treat. 2024;205(3):487-95. https://doi.org/10.1007/s10549-024-07296-9
• Barazi H, Gunduru M. Mammography BI RADS Grading. In: StatPearls. Treasure Island (FL): StatPearls Publishing; July 31, 2023.
• Sickles EA, Galvin HB. Breast arterial calcification in association with diabetes mellitus: too weak a correlation to have clinical utility. Radiology. 1985;155(3):577-9. https://doi.org/10.1148/radiology.155.3.4001355
• Cetin M, Cetin R, Tamer N. Prevalence of breast arterial calcification in hypertensive patients. Clin Radiol. 2004;59(1):92-5. https://doi.org/10.1016/j.crad.2003.09.007
• Schnatz PF, Rotter MA, Hadley S, Currier AA, O'Sullivan DM. Hormonal therapy is associated with a lower prevalence of breast arterial calcification on mammography. Maturitas. 2007;57(2):154-60. https://doi.org/10.1016/j.maturitas.2006.12.002
• Caglayan EK, Caglayan K, Alkis I, et al. Factors Associated with Mammographic Density in Postmenopausal Women. J Menopausal Med. 2015;21(2):82-8. https://doi.org/10.6118/jmm.2015.21.2.82
• Kim JH, Lee HK, Cho JH, Park HK, Yang HJ. Correlations between female breast density and biochemical markers. J Phys Ther Sci. 2015;27(7):2097-100. https://doi.org/10.1589/jpts.27.2097