Research Article

Maternal heart disease and pregnancy complications: a tertiary hospital experience from Turkiye

Volume: 11 Number: 2 March 4, 2025
EN

Maternal heart disease and pregnancy complications: a tertiary hospital experience from Turkiye

Abstract

Objectives: Maternal heart disease is a leading cause of non-obstetric maternal mortality and morbidity, complicating the necessary physiological changes during pregnancy. This study aimed to evaluate maternal and perinatal outcomes in pregnancies complicated by maternal heart disease.

Methods: A retrospective analysis was conducted from November 2022 to November 2023 at a tertiary care hospital. Ninety-three pregnant women with maternal heart disease were included and categorized into congenital heart disease, rheumatic heart disease, and other cardiac conditions. Data on demographics, obstetric complications, and perinatal outcomes were analyzed.

Results: Among the participants, 47.3% had rheumatic heart disease, 37.6% had other cardiac conditions, and 15.1% had congenital heart disease. Maternal outcomes included a 29% incidence of preterm delivery, and an 8.6% occurrence of fetal growth restriction, and 7.5% of mothers requiring postpartum intensive care. However, no maternal mortality was observed. Neonatal outcomes included a 30.3% admission rate to the neonatal intensive care unit and a 12.9% incidence of respiratory distress syndrome, with no recorded fetal mortality. Outcomes were consistent across the three cardiac disease groups, demonstrating the effectiveness of multidisciplinary care approaches.

Conclusions: Early diagnosis, individualized care, and multidisciplinary management are essential for improving outcomes in pregnancies with maternal heart disease. Despite no observed maternal or fetal mortality, high rates of preterm births and neonatal complications emphasize the need for targeted interventions. Addressing modifiable risk factors like hypertension and obesity is critical. Multicenter studies with larger cohorts are recommended to enhance management strategies.

Keywords

Ethical Statement

The study was conducted in accordance with the principles specified in the Declaration of Helsinki. The Ankara Etlik City Hospital’s Ethics Committee gave its permission to the study protocol (approval number: 2023-474 and date: 16.08.2023).

References

  1. 1. Eggleton EJ, McMurrugh KJ, Aiken CE. Perinatal outcomes in pregnancies complicated by maternal cardiomyopathy: a systematic review and meta-analysis. Am J Obstet Gynecol. 2023;228(3):283-291. doi: 10.1016/j.ajog.2022.09.025.
  2. 2. Knight M, Nair M, Brocklehurst P, et al. Examining the impact of introducing ICD-MM on observed trends in maternal mortality rates in the UK 2003-13. BMC Pregnancy Childbirth. 2016;16(1):178. doi: 10.1186/s12884-016-0959-z.
  3. 3. Yucel A, Koksal Z, Ensari T, et al. Maternal mortality due to valvular heart disease: a population-based study in Turkey. Ir J Med Sci. 2022;191(6):2531-2537. doi: 10.1007/s11845-021-02879-7.
  4. 4. Múnera-Echeverri AG. [Heart disease and pregnancy]. Rev Colomb Cardiol. 2018;25(S1):49-58. doi: 10.1016/j.rccar.2017.11.028. [Article in Spanish]
  5. 5. Nguyen Manh T, Bui Van N, Le Thi H, et al. Pregnancy with Heart Disease: Maternal Outcomes and Risk Factors for Fetal Growth Restriction. Int J Environ Res Public Health. 2019;16(12):2075. doi: 10.3390/ijerph16122075.
  6. 6. Kearney K, Zentner D, Cordina R. Management of Maternal Complex Congenital Heart Disease During Pregnancy. Curr Heart Fail Rep. 2021;18(6):353-361. doi: 10.1007/s11897-021-00534-x.
  7. 7. Chapman AB, Abraham WT, Zamudio S, et al. Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int. 1998;54(6):2056-2063. doi: 10.1046/j.1523-1755.1998.00217.x.
  8. 8. Mahendru AA, Everett TR, Wilkinson IB, Lees CC, McEniery CM. A longitudinal study of maternal cardiovascular function from preconception to the postpartum period. J Hypertens. 2014;32(4):849-856. doi: 10.1097/HJH.0000000000000090.

Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Early Pub Date

February 12, 2025

Publication Date

March 4, 2025

Submission Date

January 24, 2025

Acceptance Date

February 9, 2025

Published in Issue

Year 2025 Volume: 11 Number: 2

AMA
1.Karabay G, Şeyhanlı Z, Filiz AA, et al. Maternal heart disease and pregnancy complications: a tertiary hospital experience from Turkiye. Eur Res J. 2025;11(2):151-160. doi:10.18621/eurj.1626635