Evaluation of Cardiac Functions and Rhythm in Pediatric Patients Diagnosed with Chronic Kidney Failure

Abdullah Akkuş; Fatih Şap; Bülent Ataş; Mehmet Burhan Oflaz; Tamer Baysal

doi:10.18621/eurj.1809664

Evaluation of Cardiac Functions and Rhythm in Pediatric Patients Diagnosed with Chronic Kidney Failure

Abstract

Objectives: Chronic renal failure (CRF) represents a progressive and irreversible decline in renal function. Among individuals with end-stage renal disease (ESRD), cardiovascular disorders are recognized as the leading contributors to morbidity and mortality. The present study aimed to assess cardiac function in pediatric patients diagnosed with CRF.

Methods: This cross-sectional study included 30 pediatric patients with CRF who were under follow-up between October 2018 and August 2019, along with 30 age- and sex-matched healthy controls. The CRF group was further divided into two subgroups according to dialysis status. For all participants, conventional 12-lead electrocardiography was performed, and indices associated with atrial (P-wave dispersion, Pd) and ventricular (QT dispersion, corrected QT dispersion, Tp–e, Tp–e/QT, Tp–e/QTc) arrhythmia risk were recorded. Each subject also underwent a detailed echocardiographic evaluation, including both conventional and tissue Doppler measurements.

Results: Anthropometric characteristics and blood pressure values did not significantly differ between the patient and control groups. Apart from an increased mean corrected QT dispersion (QTcd), other electrocardiographic parameters were comparable between groups. Ejection fraction (EF) and fractional shortening (FS) values were lower in CRF patients compared with controls. LV mass index (LVMI) was significantly higher in the dialysis subgroup relative to the control group. Additionally, the myocardial performance index (Tei index) was markedly elevated in CRF patients (P<0.001).

Conclusions: These findings underscore the need for comprehensive cardiac evaluation in children with CRF. Nonetheless, larger-scale studies are warranted to confirm and expand upon these observations.

Keywords

Ethical Statement

This study was approved by the Necmettin Erbakan University Meram Faculty of Medicine Non-Drug and Medical Device Research Ethics Committee (Decision No: 2018/71448-72; date: 29.06.2018). All procedures were conducted in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments. Written informed consent was obtained from all individual participants included in the study.

Thanks

We are grateful to Prof. Dr. Bülent Atas, who deceased during the conduction of this study, for his invaluable efforts and contributions to the field of medicine.

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Details

Primary Language

English

Subjects

Pediatric Cardiology

Journal Section

Research Article

Authors

Abdullah Akkuş ^*
0000-0002-0642-8759
Türkiye

Fatih Şap
0000-0001-7870-9704
Türkiye

Bülent Ataş
0000-0003-2708-8738
Türkiye

Mehmet Burhan Oflaz
0000-0003-1515-4654
Türkiye

Tamer Baysal
0000-0001-6145-1831
Türkiye

Early Pub Date

December 19, 2025

Publication Date

February 1, 2026

Submission Date

October 23, 2025

Acceptance Date

November 24, 2025

Published in Issue

Year 2026 Volume: 12 Number: 2

DOI

https://doi.org/10.18621/eurj.1809664

IZ

https://izlik.org/JA63UX29TJ

Cite

RIS / Bibtex

AMA

1.Akkuş A, Şap F, Ataş B, Oflaz MB, Baysal T. Evaluation of Cardiac Functions and Rhythm in Pediatric Patients Diagnosed with Chronic Kidney Failure. Eur Res J. 2026;12(2):173-186. doi:10.18621/eurj.1809664