Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study

Candan Çelik; Mehmet Semih Çelik

doi:10.18621/eurj.1829668

Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study

Abstract

Objectives: Atopic dermatitis is a chronic inflammatory skin condition with a multifactorial etiology involving genetic, environmental, and immunologic influences. Although several mechanisms have been proposed, the potential association between ABO/Rh blood groups and the risk of developing atopic dermatitis is still uncertain. The present study sought to investigate the distribution of ABO and Rh blood groups in individuals with atopic dermatitis compared with healthy, age- and sex-matched controls.

Methods: A retrospective analysis was performed covering a 10-year interval (2014–2024). The study included 3,470 patients diagnosed with atopic dermatitis and 7,449 matched controls, yielding a total sample of 10,919 individuals. Demographic data and blood group characteristics (ABO and Rh typing) were collected and evaluated.

Results: The O Rh– phenotype was observed significantly more often in patients with atopic dermatitis than in controls (5.2% vs. 3.5%; OR=1.52, 95% CI: 1.25–1.85; P<0.001). Conversely, the A Rh– blood group was notably less frequent in atopic dermatitis patients compared with the control group (3.7% vs. 4.7%; OR=0.79, 95% CI: 0.64–0.96; P=0.021).

Conclusions: The findings indicate that the general distribution of ABO and Rh blood groups among patients with atopic dermatitis is comparable to that of healthy individuals. However, the increased prevalence of the O Rh– type and the lower frequency of A Rh– among atopic dermatitis patients suggest that specific blood group antigens may influence susceptibility to atopic dermatitis. Future large-scale, multicenter, and prospective studies are required to further elucidate this potential relationship.

Keywords

Ethical Statement

This study was approved by the University of Health Sciences, Gazi Yaşargil Training and Research Hospital Clinical Research Ethics Committee (Decision No: 2025/440; date: 25.04.2025. All procedures were conducted in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments. Because the study was retrospective and no additional intervention was performed on the participants, the informed consent form was waived.

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Details

Primary Language

English

Subjects

Dermatology

Journal Section

Research Article

Authors

Candan Çelik
0009-0008-6759-388X
Türkiye

Mehmet Semih Çelik ^*
0000-0002-3378-0619
Türkiye

Early Pub Date

January 6, 2026

Publication Date

March 1, 2026

Submission Date

November 24, 2025

Acceptance Date

January 4, 2026

Published in Issue

Year 2026 Volume: 12 Number: 3

DOI

https://doi.org/10.18621/eurj.1829668

IZ

https://izlik.org/JA72GL48PM

Cite

RIS / Bibtex

APA

Çelik, C., & Çelik, M. S. (2026). Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study. The European Research Journal, 12(3), 323-328. https://doi.org/10.18621/eurj.1829668

AMA

1.Çelik C, Çelik MS. Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study. Eur Res J. 2026;12(3):323-328. doi:10.18621/eurj.1829668

Chicago

Çelik, Candan, and Mehmet Semih Çelik. 2026. “Distribution of Blood Groups in Patients With Atopic Dermatitis: A Retrospective Case-Control Study”. The European Research Journal 12 (3): 323-28. https://doi.org/10.18621/eurj.1829668.

EndNote

Çelik C, Çelik MS (March 1, 2026) Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study. The European Research Journal 12 3 323–328.

IEEE

[1]C. Çelik and M. S. Çelik, “Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study”, Eur Res J, vol. 12, no. 3, pp. 323–328, Mar. 2026, doi: 10.18621/eurj.1829668.

ISNAD

Çelik, Candan - Çelik, Mehmet Semih. “Distribution of Blood Groups in Patients With Atopic Dermatitis: A Retrospective Case-Control Study”. The European Research Journal 12/3 (March 1, 2026): 323-328. https://doi.org/10.18621/eurj.1829668.

JAMA

1.Çelik C, Çelik MS. Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study. Eur Res J. 2026;12:323–328.

MLA

Çelik, Candan, and Mehmet Semih Çelik. “Distribution of Blood Groups in Patients With Atopic Dermatitis: A Retrospective Case-Control Study”. The European Research Journal, vol. 12, no. 3, Mar. 2026, pp. 323-8, doi:10.18621/eurj.1829668.

Vancouver

1.Candan Çelik, Mehmet Semih Çelik. Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study. Eur Res J. 2026 Mar. 1;12(3):323-8. doi:10.18621/eurj.1829668