Yıl 2019, Cilt 5 , Sayı 5, Sayfalar 734 - 739 2019-09-04

Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population

Yurdaer DÖNMEZ [1] , Hasan KOCA [2] , Yahya Kemal İÇEN [3] , Mustafa DEMİRTAŞ [4]


Objectives: Factor VII has a crucial role in the extrinsic coagulation pathway and initiates the thrombus formation. Some studies showed that high plasma factor VII level was related to increased acute myocardial infarction (AMI) risk. But, some studies were reported opposite findings. Some polymorphisms can change the factor VII level. There is limited information about factor VII polymorphisms in southern Turkey population. Our aim was to determine the frequencies of Factor VII-401 and -402 polymorphisms and their relation to AMI in southern Turkey area.

Methods: We enrolled 83 patients with AMI and 71 healthy subjects. Routine laboratory tests and factor VII-401 and -402 polymorphisms were determined from blood samples. Factor VII -401 and -402 polymorphisms were analyzed by LightCycler device using Real-Time PCR technique.

Results: Family history of coronary artery disease and smoking frequencies were higher in patients group (p < 0.001 and p = 0.013, respectively). Patients had higher LDL cholesterol (p = 0.011) level, and lower HDL cholesterol (p = 0.025) level compared to healthy subjects. Factor VII-401 and -402 polymorphism genotypes were not significantly different in both groups. Also allele frequencies were similar in both groups.

Conclusion: Factor VII-401 and -402 polymorphisms do not seem to increase AMI risk in southern Turkey. 

Acute myocardial infarction, factor VII-401 and -402 polymorphisms
  • [1] Rao LV, Rapaport SI. Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation. Proc Natl Acad Sci USA 1988;85:6687-91.
  • [2] Sakakibara H, Fujii C, Naito M. Plasma fibrinogen and its association with cardiovascular risk factors in apparently healthy Japanese subjects. Heart Vessels 2004;19:144-8.
  • [3] Broze GJ Jr, Majerus PW. Purification and properties of human coagulation factor VII. J Biol Chem 1980;255:1242-7.
  • [4] Meade TW, Ruddock V, Stirling Y, Chakrabarti R, Miller GJ. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 1993;342:1076-9.
  • [5] Heinrich J, Balleisen L, Schulte H, Assmann G, van de Loo J. Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler Thromb 1994;14:54-9.
  • [6] Heywood DM, Ossei-Gerning N, Grant PJ. Association of factor VII:C levels with environmental and genetic factors in patients with ischaemic heart disease and coronary atheroma characterised by angiography. Thromb Haemost 1996;76:161-5.
  • [7] Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE. Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1997;96:1102-8.
  • [8] Green F, Humphries S. Genetic determinants of arterial thrombosis. Baillieres Clin Haematol 1994;7:675-92.
  • [9] van't Hooft FM, Silveira A, Tornvall P, Iliadou A, Ehrenborg E, Eriksson P, et al. Two common functional polymorphisms in the promoter region of the coagulation factor VII gene determining plasma factor VII activity and mass concentration. Blood 1999;93:3432-41.
  • [10] Matheus AS, Tannus LR, Cobas RA, Palma CC, Negrato CA, Gomes MB. Impact of diabetes on cardiovascular disease: an update. Int J Hypertens 2013;2013:653789.
  • [11] Endler G, Mannhalter C. Polymorphisms in coagulation factor genes and their impact on arterial and venous thrombosis. Clin Chim Acta 2003;330:31-55.
  • [12] Grant PJ, Humphries SE. Genetic determinants of arterial thrombosis. Baillieres Best Pract Res Clin Haematol 1999;12:505-32.
  • [13] Iacoviello L, Di Castelnuovo A, de Knijff P, D'Orazio A, Amore C, Arboretti R, et al. Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction. N Engl J Med 1998;338:79-85.
  • [14] Girelli D, Russo C, Ferraresi P, Olivieri O, Pinotti M, Friso S, et al. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N Engl J Med 2000;343:774-80.
  • [15] Corral J, González-Conejero R, Lozano ML, Rivera J, Vicente V. Genetic polymorphisms of factor VII are not associated with arterial thrombosis. Blood Coagul Fibrinolysis 1998;9:267-72.
  • [16] Lane A, Green F, Scarabin PY, Nicaud V, Bara L, Humphries S, et al. Factor VII Arg/Gln353 polymorphism determines factor VII coagulant activity in patients with myocardial infarction (MI) and control subjects in Belfast and in France but is not a strong indicator of MI risk in the ECTIM study. Atherosclerosis 1996;119:119-27.
  • [17] Kang WY, Wang HL, Xiong LF, Wang XF, Chu HY, Qu B, et al. Study on plasma coagulation factor VII (FVII) levels and polymorphisms of FVII gene in patients with coronary heart diseas. Zhonghua Xue Ye Xue Za Zhi 2002;23:457-9.
  • [18] Kang WY, Wang HL, Xiong LF, Wang XF, Chu HY, Qu B, et al. Polymorphisms of the coagulation factor VII gene and its plasma levels in relation to acute cerebral infarction differences in allelic frequencies between Chinese Han and European populations. Chin Med 2004;117:71-4.
  • [19] Evangelista FC, Rios DR, Ribeiro DD, Carvalho MG, Dusse LM, Fernandes AP, et al. Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis. Genet Mol Res 2015;14:9585-94.
  • [20] Ramzi M, Cohan N, Yavarian M, Jahromi MR, Beigi MB, Fakhraee F, et al. Coagulation factor VII gene polymorphisms and cardiovascular diseases in Iranian population. J Indian Coll Cardiol 2013;3:6-8.
  • [21] Wang XL, Wang J, McCredie RM, Wilcken DE. Polymorphisms of factor V, factor VII, and fibrinogen genes. Relevance to severity of coronary artery disease. Arterioscler Thromb Vasc Biol 1997;17:246-51.
  • [22] Shimokata K, Kondo T, Ohno M, Takeshita K, Inden Y, Iino S, et al. Effects of coagulation Factor VII polymorphisms on the coronary artery disease in Japanese: Factor VII polymorphism and coronary disease. Thromb Res 2002;105:493-8.
Birincil Dil en
Konular Biyokimya ve Moleküler Biyoloji, Kalp ve Kalp Damar Sistemi
Bölüm Original Article
Yazarlar

Orcid: 0000-0003-4745-7801
Yazar: Yurdaer DÖNMEZ (Sorumlu Yazar)
Kurum: Department of Cardiology, University of Health Sciences, Adana Health Practices and Research Centre, Adana, Turkey
Ülke: Turkey


Orcid: 0000-0002-6232-4567
Yazar: Hasan KOCA
Kurum: Department of Cardiology, University of Health Sciences, Adana Health Practices and Research Centre, Adana, Turkey
Ülke: Turkey


Orcid: 0000-0003-0070-5281
Yazar: Yahya Kemal İÇEN
Kurum: Department of Cardiology, University of Health Sciences, Adana Health Practices and Research Centre, Adana, Turkey
Ülke: Turkey


Orcid: 0000-0003-3560-7489
Yazar: Mustafa DEMİRTAŞ
Kurum: Department of Cardiology, Çukurova University School of Medicine, Adana, Turkey
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 4 Eylül 2019

EndNote %0 The European Research Journal Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population %A Yurdaer Dönmez , Hasan Koca , Yahya Kemal İçen , Mustafa Demi̇rtaş %T Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 5 %R doi: 10.18621/eurj.421781 %U 10.18621/eurj.421781