Beta endorphins - molecules of therapeutics

Abstract

Endorphins are endogenous morphine, neuropeptides produced in the pituitary gland. There are three types of endorphins beta-endorphins, enkephalins, and dynorphins. Beta-endorphins are an abundant endorphins synthesized and stored in the anterior pituitary gland; it is a precursor of POMC (Proopiomelanocortin). Beta-endorphins has got various mechanisms of actions such as anti-inflammatory activity, analgesic activity, stress buster activity, and immune stimulatory activity can be used to treat various diseases such as chronic inflammatory diseases such as heart disease, Alzheimer’s disease, cancer, auto-immune disease, diabetes mellitus, and aging. This article highlights about the basic research findings of beta-endorphins and mechanisms of actions in management of various diseases.

Keywords

• NF-KB,STAT-3,Cortisol,ACTH,Noradrenaline

References

1. 1. Shrihari TG. Endorphins on cancer: a novel therapeutic approach. J Carcinog Mutagen 2017;8:298.
2. 2. Shrihari TG. Endorphins - A novel hidden magic holistic healer. J Clin Cell Immunol 2018;9:547-52.
3. 3. Shrihari TG. Endorphins - A forgotten hidden magic holistic healer: Minireview. Adv Complement Alt Med 2018;2:170-2.
4. 4. Shrihari TG. Beta-Endorphins - A novel natural holistic healer. J Microb Biochem Technol 2018;10:25-6.
5. 5. IwaszkiewicZ KS, Schneider JJ, Hua S. Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions. Front Pharmacol 2013;4:132.
6. 6. Hua S. Neuroimmune interaction in the regulation of peripheral opioid mediated analgesia in inflammation. Front Immunol 2016;7:293.
7. 7. Shrihari TG. Dual role of inflammatory mediators in cancer. Ecancermedicalscience 2017;11:721.
8. 8. Shrihari TG. Quantum healing approach to new generation of holistic healing. Transl Med 2017;7:198.

9. 9. Zhang CQ. Role of Beta-endorphin in control of stress and cancer progression in fetal alcohol exposed rats. Thesis. 2013. doi:10.7282/T3XS5SG3.