Yıl 2019, Cilt 5 , Sayı 5, Sayfalar 836 - 846 2019-09-04

The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients

Nizameddin KOCA [1] , Alparslan ERSOY [2] , Barış ŞENSOY [3] , Emine KIRHAN [4] , Sümeyye GÜLLÜLÜ [5] , Melahat DİRİCAN [6] , Emre SARANDÖL [7]


Objectives: Kidney transplantation recipients (KTRs) have higher cardiovascular complications risk compared to the general population. Cardiovascular risk factors (CVRF, Traditional and non-traditional) are widely studied to understand the causes of increased cardiovascular disease (CVD) risk in KTRs. Fetuin-A prevents from vascular calcification (VC) by inhibiting production and collapsing of apatite crystals to the vascular wall. The relationship between fetuin-A levels and CVRF in KTRs was investigated in this study.

Methods: Sixty-two KTRs with no prior CVD history participated. Anthropometrical, laboratory (fetuin-A, inflammation markers, antioxidants, lipid peroxidation products) and cardiological (echocardiographic, pulse wave velocity) measurements were performed. Participants were divided into two groups according to normal (≥ 0.5 g/L, n = 32, NFA) and low (< 0.5 g/L, n = 30, LFA) fetuin-A levels according to manufacturer’s reference range, and the results were compared.

Results: No significant difference was observed in demographic features, body mass index, systolic and diastolic blood pressures, left ventricle mass index, waist and hip circumferences, left ventricle hypertrophy and waist-hip ratios between the two groups (p > 0.05). The ratios of drug usage such as immunosuppressives, anti-hypertensives and statin were comparable between two groups. Parathormone levels were significantly higher in the NFA group (p = 0.015) and glomerular filtration rate was calculated significantly higher in LFA group (p = 007). The comparison of other CVRF reveals no significant difference (p > 0.05).

Conclusions: Although many CVRF improved in KTRs, subclinical inflammation markers were still higher than the healthy population. Identification and early recognition of CVRF in high-risk individuals may contribute to the reduction of cardiovascular mortality. In our study, we observed no significant relationship between fetuin-A levels and CVRFs. We evaluated the relationship between serum fetuin-A levels on cardiovascular risk factors by its role in pathophysiology. 

Kidney transplantation, cardiovascular risk factor, fetuin-A
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Birincil Dil en
Konular Biyokimya ve Moleküler Biyoloji, Kalp ve Kalp Damar Sistemi, Transplantasyon, Üroloji ve Nefroloji
Bölüm Original Article
Yazarlar

Orcid: 0000-0003-1457-4366
Yazar: Nizameddin KOCA (Sorumlu Yazar)
Kurum: Department of Internal Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0002-0710-0923
Yazar: Alparslan ERSOY
Kurum: Department of Nephrology & Transplantation, Uludağ University School of Medicine, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0003-0066-9946
Yazar: Barış ŞENSOY
Kurum: Department of Cardiology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0003-1521-9366
Yazar: Emine KIRHAN
Kurum: Department of Biochemistry, Tavşanlı State Hospital, Kütahya, Turkey
Ülke: Turkey


Orcid: 0000-0003-2831-002X
Yazar: Sümeyye GÜLLÜLÜ
Kurum: Department of Cardiology, Uludağ University School of Medicine, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0002-4956-5278
Yazar: Melahat DİRİCAN
Kurum: Department of Biochemistry, Uludağ University School of Medicine, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0002-2593-7196
Yazar: Emre SARANDÖL
Kurum: Department of Biochemistry, Uludağ University School of Medicine, Bursa, Turkey
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 4 Eylül 2019

EndNote %0 The European Research Journal The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients %A Nizameddin Koca , Alparslan Ersoy , Barış Şensoy , Emine Kırhan , Sümeyye Güllülü , Melahat Di̇ri̇can , Emre Sarandöl %T The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 5 %R doi: 10.18621/eurj.572606 %U 10.18621/eurj.572606