The effect of teicoplanin coating on osteointegration of titanium screws: a biomechanical and histomorphometric study in a rabbit model

Abstract

Objectives: The aim of this experimental animal study was to make a biomechanical and histomorphometric evaluation of the effects of titanium screws covered with teicoplanin, which is wanted to prevent the development of infection, on osteointegration of the screw.

Methods: Twenty New Zealand white rabbits were randomly separated into 2 groups. In Group 1, 2 mini screws with teicoplanin coating were placed in the femoral condyles of the right knee and in Group 2, 2 mini screws with no coating. After 4 weeks, all the animals were sacrificed and prepared for biomechanical and histological examinations.

Results: In the pull-out test, the values of Group 1 were found to be higher and in the removal torque test, the values of Group 2 were higher. No positive correlation was found between the pull-out and removal torque tests (r = 0.88). The bone-implant contact value was found to be similar in both groups (p = 0.132).

Conclusions: The results showed that titanium screws with teicoplanin coating did not interfere with osteointegration process biomechanically andhistomorphometrically by comparison with screws having no coating so that teicoplanincoating can be considered for use in orthopedic devices and joint prosthesis to prevent the development of infection. 

Keywords

• teicoplanin
• osteointegration
• histomorphometry
• biomechanics
• titanium

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