Effect of metaclopramide on urinary bladder smooth muscle contraction-relaxation mechanism

Abstract

Objectives: Metoclopramide, a dopamine receptor antagonist, a benzamide, is a commonly used antiemetic drug in many diseases with nausea and vomiting. The aim of this study is to examine the effects of metoclopramide, which is also used in urinary system infections, on the urinary bladder contraction-relaxation mechanism.

Methods: In the study, bladder tissue strips obtained from adult female Wistar rats in diestrus were placed in an isolated organ bath containing Krebs solution. The effect of metoclopramide at concentrations of 10 µM and 20 µM on sections where spontaneous contractions were observed under 1.5 g of tension was investigated.

Results: Metaclopramide caused a statistically significant increase in the area under the contraction curve (AUC) and peak to peak (p-p) parameters of spontaneous bladder contractions at concentrations of 10 and 20 μM (p < 0.01).

Conclusions: Metaclopramide has an activator effect on spontaneous bladder contractions. This effect should be taken into consideration in clinical use, especially when used in urinary system infections.

Keywords

• Metoclopramide
• urinary bladder
• isometric contraction
• rat

References

1. 1. Ponte CD, Nappi JM. Review of a new gastrointestinal drug--metoclopramide. Am J Hosp Pharm 1981;38:829-33.
2. 2. DiPalma J. Metoclopramide: a dopamine receptor antagonist. Am Fam Physician 1990;41:919-24.
3. 3. van der Padt A, van Schaik RH, Sonneveld P. Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms. Neth J Med 2006;64:160-2.
4. 4. Kohli-Kumar M, Pearson ADJ, Sharkey I, Craft AW. Urinary retention-an unusual dystonic reaction to continuous metoclopramide infusion. DICP 1991;25:469-70.
5. 5. Mitchell WC, Venable DD. Effects of metoclopramide on detrusor function. J Urol 1985;134:791-4.
6. 6. Robain G, Combrisson H, Perrigot M. Effects of metoclopramide on urethral pressure profile of healthy dogs. J Urol 1995;154:1545-7.
7. 7. Little W, Bissada N, Fredericks C, Finkbeiner A. In vitro action of metoclopramide on guinea pig bladder. Afr J Urol 1998;4:12-9.
8. 8. Nestler JE, Stratton MA, Hakim CA. Effect of metoclopramide on diabetic neurogenic bladder. Clin Pharm 1983;2:83-5.

9. 9. Vaidyanathan S, Rao M, Bapna B, Chary K, Swamy R. Role of dopamine receptors in vesicourethral function. A urodynamic study with dopamine receptor antagonist metoclopramide. Ann Clin Res 1980;12:1-4.