Year 2017,
Volume: 3 Issue: 2, 111 - 117, 04.07.2017
Haci Murat Cayci
,
Umut Eren Erdogdu
,
Mehmet Akif Turkoglu
,
Suleyman Orman
,
Hasan Cantay
Evren Dilektasli
References
- [1] Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013;63:11-30.
- [2] Hu CJ, Liao CC, Chang CC, Wu CH, Chen TL. Postoperative adverse outcomes in surgical patients with dementia: a retrospective cohort study. World J Surg 2012;36:2051-8.
- [3] Partridge JS, Harari D, Dhesi JK. Frailty in the older surgical patient: a review. Age Ageing 2012;41:142-7.
- [4] Sawhney R, Sehl M, Naeim A. Physiological aspects of aging: impact on cancer management and decision making. Part I. Cancer J 2005;11:449-60.
- [5] Cheung HY, Chung CC, Fung JT, Wong JC, Yau KK, Li MK. Laparoscopic resection for colorectal cancer in octogenarians: results in a decade. Dis Colon Rectum 2007;50:1905-10.
- [6] Colorectal Cancer Collaborative Group: Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 2000;356:968-74.
- [7] Shahir MA, LemmensVE,van de Poll-Franse LV, Voogd AC, Martijn H, Janssen-Heijnen ML. Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: a population-based study. Eur J Cancer 2006;42:3015-21.
- [8] Malkhosyan SR, Yamamoto H, Piao Z, Perucho M. Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women. Gastroenterology 2000;119:98.
- [9] Arai T, Takubo K, Sawabe M, Esaki Y. Pathologic characteristics of colorectal cancer in the elderly: a retrospective study of 947 surgical cases. J Clin Gastroenterol 2000;31:67-72.
- [10] Basili G, Lorenzetti L, Biondi G, Preziuso E, Angrisano C, Carnesecchi P, et al. Colorectal cancer in the elderly. Is there a role for safe and curative surgery? ANZ J Surg 2008;78:466-70.
- [11] Tekkis PP, Kinsman R, Thompson MR, Stamatakis JD. The Association of Coloproctology of Great Britain and Ireland study of large bowel obstruction caused by colorectal cancer. Ann Surg 2004;240:76-81.
- [12] Gross CP, Guo Z, McAvay GJ, Allore HG, Young M, Tinetti ME. Multimorbidity and survival in older persons with colorectal cancer. J Am Geriatr Soc 2006;54:1898-904.
- [13] Faivre J, LemmensVE, Quipourt V, Bouvier AM. Management and survival of colorectal cancer in the elderly in population-based studies. Eur J Cancer 2007;43:2279-84.
- [14] Theocharis GJ, Arvaniti V, Assimakopoulos SF, Thomopoulos KC, Xourgias V, Mylonakou I, et al. Acute upper gastrointestinal bleeding in octogenarians: clinical outcome and factors related to mortality. World J Gastroenterol 2008;14:4047-53.
- [15] Surgery for colorectal cancer in elderly patients: a systematic review. Colorectal Cancer Collaborative Group. Lancet 2000;356:968-74.
- [16] Marusch F, Koch A, Schmidt U, Steinert R, Ueberrueck T, Bittner R, et al. The impact of the risk factor “age” on the early postoperative results of surgery for colorectal carcinoma and its significance for perioperative management. World J Surg 2005;29:1013-121.
- [17] Frasson M, Braga M, Vignali A, Zuliani W, Di Carlo V. Benefits of laparoscopic colorectal resection are more pronounced in elderly patients. Dis Colon Rectum 2008;51:296-300.
- [18] The Colon Cancer Laparoscopic or Open Resection Study Group. Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial. Lancet Oncol 2009;10: 44-52.
- [19] Vignali A, DiPalo S, Tamburini A, Radaelli G, Orsenigo E, Staudacher C. Laparoscopic vs. open colectomies in octogenarians: A case-matched control study. Dis Colon Rectum 2005;48:2070-5.
- [20] Hildebrandt U, Kessler K, Plusczyk T, Pistorius G, Vollmar B, Menger MD. Comparison of surgical stress between laparoscopic and open colonic resections. Surg Endosc 2003;17:242-6.
- [21] Phillips PS, Farquharson SM, Sexton R, Heald RJ, Moran BJ. Rectal cancer in the elderly: patients’ perception of bowel control after restorative surgery. Dis Colon Rectum 2004;47:287-90.
- [22] Pinto RA, Ruiz D, Edden Y, Weiss EG, Nogueras JJ, Wexner SD. How reliable is laparoscopic colorectal surgery compared with laparotomy for octogenarians? Surg Endosc 2011;25:2692-8.
- [23] Laurent C, Leblanc F, Wutrich P, Scheffler M, Rullier E. Laparoscopic versus open surgery for rectal cancer. Long term oncological results. Ann Surg 2009;250:54-61.
- [24] Lujan J, Valero G, Hernandez A, Sanchez A, Frutos MD, Parrilla P. Randomized clinical trial comparing laparoscopic and open surgery in patients with rectal cancer. Br J Surg 2009;96:982-9.
- [25] Issa N, Grassi C, Melki Y, Powsner E, Dreznik Z. Laparoscopic colectomy for carcinoma of the colon in octogenarians. J Gastrointest Surg 2011;15:2011-5.
- [26] Akiyoshi T, Kuroyanagi H, Oya M, Konishi T, Fukuda M, Fujimoto Y, et al. Short-term outcomes of laparoscopic rectal surgery for primary rectal cancer in elderly patients: is it safe and beneficial? J Gastrontest Surg 2009;13:1614-8.
- [27] Rutten H, den Dulk M, Lemmens V, Nieuwenhuijzen G, Krijnen P, Jansen-Landheer M, et al. Survival of elderly rectal cancer patients not improved: analysis of population based data on the impact of TME surgery. Eur J Cancer 2007;43:2295-300.
- [28] Fielding LP, Phillips RK, Hittinger R. Factors influencing mortality after curative resection for large bowel cancer in elderly patients. Lancet 1989;333:595-7.
- [29] Irvin TT. Prognosis of colorectal cancer in the elderly. Br J Surg 1988;75:419-21.
- [30] Hermans E, vanSchaik PM, Prins HA, Ernst MF, Dautzenberg PJ, Bosscha K. Outcome of colonic surgery in elderly patients with colon cancer. J Oncol 2010;2010:865908.
- [31] Widdison AL, Barnett SW, Betambeau N. The impact of age on outcome after surgery for colorectal adenocarcinoma. Ann R Coll Surg Engl 2011;93:445-50.
- [32] Tan KY, Kawamura Y, MizokamiK, Sasaki J, Tsujinaka S, Maeda T, et al. Colorectal surgery in octogenarian patients – outcomes and predictors of morbidity. Int J Colorectal Dis 2009;24:185-9.
- [33] Modini C, Romagnoli F, De Milito R, Romeo V, Petroni R, La Torre F, et al. Octogenarians: an increasing challenge for acute care and colorectal surgeons. An outcomes analysis of emergency colorectal surgery in the elderly. Colorectal Dis 2012;14:312-8.
- [34] Leong QM, Aung MO, Ho CK, Sim R. Emergency colorectal resections in Asian octogenarians: factors impacting surgical outcome. SurgToday 2009;39:575-9.
- [35] Kllingback M, Barron P, Dent O. Elective resection and anastomosis for colorectal caner: a prospective audit of mortality and morbidity 1976-1998. Aust N Z J Surg 2008;72:689-98.
- [36] Ozturk E, Yilmazlar T. Factors affecting the mortality risk in elderly patients undergoing surgery. ANZ J Surg 2007;77:156-9.
- [37] Kotake K, Asano M, Ozawa H, Kobayashi H, Sugihara K. Tumour characteristics, treatment patterns and survival of patients aged 80 years or older with colorectal cancer. Colorectal Disease 2014;17:205-15.
- [38] Patel SS, Nelson R, Sanchez J, Lee W, Uyeno L, Garcia-Aguilar J, et al. Elderly patients with colon cancer have unique tumor characteristics and poor survival. Cancer 2013;119:739-47.
- [39] ASheikh A, Joel AS, Johnson MA, Vimalachandran D. Outcome of colorectal cancer resection in octogenarians. S Afr J Surg 2013;51:68-72.
- [40] Devon KM, Vergara-Fernandez O, Victor JC, McLeod RS. Colorectal cancer surgery in elderly patients: presentation, treatment, and outcomes. Dis Colon Rectum 2009;52:1272-7.
Colorectal surgery in octogenarian patients: is it safe?
Year 2017,
Volume: 3 Issue: 2, 111 - 117, 04.07.2017
Haci Murat Cayci
,
Umut Eren Erdogdu
,
Mehmet Akif Turkoglu
,
Suleyman Orman
,
Hasan Cantay
Evren Dilektasli
Abstract
Objectives. The aim of this
study was to evaluate the efficiency and safety of resection for colorectal
malignancy in elderly patients, by comparing the data from octogenarian (80+
years) patients with other patients of different ages undergoing this
procedure. Methods. Data from 80 patients who underwent elective surgery
for colorectal malignancy,by a single surgeon in the same center between the
dates of May 2013 and May 2015, were evaluated retrospectively. For comparison
purposes, patients were classified into three age groups: 65 years and under;
between the ages of 66 and 79; and 80+ years old. Demographic features; the
presence of comorbidity; colon tumor location; permeation features during colonoscopy;
resection type and method; morbidity and mortality; lymph node metastasis and
stage of the disease; follow-up period; recurrence during follow-up; and
survival data of the patients were recorded and evaluated. Results. Statistically,
no significant difference was detected between the three age groups in terms of
demographic features; presence of comorbidity; colon tumor location; permeation
features in colonoscopy; resection type and method; morbidity and mortality;
lymph node metastasis and stage of the disease; follow-up period; recurrence
during follow-up; or survival data. Conclusion. Curative resections for
colorectal cancer can be safely carried out in octogenarian patients.
References
- [1] Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013;63:11-30.
- [2] Hu CJ, Liao CC, Chang CC, Wu CH, Chen TL. Postoperative adverse outcomes in surgical patients with dementia: a retrospective cohort study. World J Surg 2012;36:2051-8.
- [3] Partridge JS, Harari D, Dhesi JK. Frailty in the older surgical patient: a review. Age Ageing 2012;41:142-7.
- [4] Sawhney R, Sehl M, Naeim A. Physiological aspects of aging: impact on cancer management and decision making. Part I. Cancer J 2005;11:449-60.
- [5] Cheung HY, Chung CC, Fung JT, Wong JC, Yau KK, Li MK. Laparoscopic resection for colorectal cancer in octogenarians: results in a decade. Dis Colon Rectum 2007;50:1905-10.
- [6] Colorectal Cancer Collaborative Group: Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 2000;356:968-74.
- [7] Shahir MA, LemmensVE,van de Poll-Franse LV, Voogd AC, Martijn H, Janssen-Heijnen ML. Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: a population-based study. Eur J Cancer 2006;42:3015-21.
- [8] Malkhosyan SR, Yamamoto H, Piao Z, Perucho M. Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women. Gastroenterology 2000;119:98.
- [9] Arai T, Takubo K, Sawabe M, Esaki Y. Pathologic characteristics of colorectal cancer in the elderly: a retrospective study of 947 surgical cases. J Clin Gastroenterol 2000;31:67-72.
- [10] Basili G, Lorenzetti L, Biondi G, Preziuso E, Angrisano C, Carnesecchi P, et al. Colorectal cancer in the elderly. Is there a role for safe and curative surgery? ANZ J Surg 2008;78:466-70.
- [11] Tekkis PP, Kinsman R, Thompson MR, Stamatakis JD. The Association of Coloproctology of Great Britain and Ireland study of large bowel obstruction caused by colorectal cancer. Ann Surg 2004;240:76-81.
- [12] Gross CP, Guo Z, McAvay GJ, Allore HG, Young M, Tinetti ME. Multimorbidity and survival in older persons with colorectal cancer. J Am Geriatr Soc 2006;54:1898-904.
- [13] Faivre J, LemmensVE, Quipourt V, Bouvier AM. Management and survival of colorectal cancer in the elderly in population-based studies. Eur J Cancer 2007;43:2279-84.
- [14] Theocharis GJ, Arvaniti V, Assimakopoulos SF, Thomopoulos KC, Xourgias V, Mylonakou I, et al. Acute upper gastrointestinal bleeding in octogenarians: clinical outcome and factors related to mortality. World J Gastroenterol 2008;14:4047-53.
- [15] Surgery for colorectal cancer in elderly patients: a systematic review. Colorectal Cancer Collaborative Group. Lancet 2000;356:968-74.
- [16] Marusch F, Koch A, Schmidt U, Steinert R, Ueberrueck T, Bittner R, et al. The impact of the risk factor “age” on the early postoperative results of surgery for colorectal carcinoma and its significance for perioperative management. World J Surg 2005;29:1013-121.
- [17] Frasson M, Braga M, Vignali A, Zuliani W, Di Carlo V. Benefits of laparoscopic colorectal resection are more pronounced in elderly patients. Dis Colon Rectum 2008;51:296-300.
- [18] The Colon Cancer Laparoscopic or Open Resection Study Group. Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial. Lancet Oncol 2009;10: 44-52.
- [19] Vignali A, DiPalo S, Tamburini A, Radaelli G, Orsenigo E, Staudacher C. Laparoscopic vs. open colectomies in octogenarians: A case-matched control study. Dis Colon Rectum 2005;48:2070-5.
- [20] Hildebrandt U, Kessler K, Plusczyk T, Pistorius G, Vollmar B, Menger MD. Comparison of surgical stress between laparoscopic and open colonic resections. Surg Endosc 2003;17:242-6.
- [21] Phillips PS, Farquharson SM, Sexton R, Heald RJ, Moran BJ. Rectal cancer in the elderly: patients’ perception of bowel control after restorative surgery. Dis Colon Rectum 2004;47:287-90.
- [22] Pinto RA, Ruiz D, Edden Y, Weiss EG, Nogueras JJ, Wexner SD. How reliable is laparoscopic colorectal surgery compared with laparotomy for octogenarians? Surg Endosc 2011;25:2692-8.
- [23] Laurent C, Leblanc F, Wutrich P, Scheffler M, Rullier E. Laparoscopic versus open surgery for rectal cancer. Long term oncological results. Ann Surg 2009;250:54-61.
- [24] Lujan J, Valero G, Hernandez A, Sanchez A, Frutos MD, Parrilla P. Randomized clinical trial comparing laparoscopic and open surgery in patients with rectal cancer. Br J Surg 2009;96:982-9.
- [25] Issa N, Grassi C, Melki Y, Powsner E, Dreznik Z. Laparoscopic colectomy for carcinoma of the colon in octogenarians. J Gastrointest Surg 2011;15:2011-5.
- [26] Akiyoshi T, Kuroyanagi H, Oya M, Konishi T, Fukuda M, Fujimoto Y, et al. Short-term outcomes of laparoscopic rectal surgery for primary rectal cancer in elderly patients: is it safe and beneficial? J Gastrontest Surg 2009;13:1614-8.
- [27] Rutten H, den Dulk M, Lemmens V, Nieuwenhuijzen G, Krijnen P, Jansen-Landheer M, et al. Survival of elderly rectal cancer patients not improved: analysis of population based data on the impact of TME surgery. Eur J Cancer 2007;43:2295-300.
- [28] Fielding LP, Phillips RK, Hittinger R. Factors influencing mortality after curative resection for large bowel cancer in elderly patients. Lancet 1989;333:595-7.
- [29] Irvin TT. Prognosis of colorectal cancer in the elderly. Br J Surg 1988;75:419-21.
- [30] Hermans E, vanSchaik PM, Prins HA, Ernst MF, Dautzenberg PJ, Bosscha K. Outcome of colonic surgery in elderly patients with colon cancer. J Oncol 2010;2010:865908.
- [31] Widdison AL, Barnett SW, Betambeau N. The impact of age on outcome after surgery for colorectal adenocarcinoma. Ann R Coll Surg Engl 2011;93:445-50.
- [32] Tan KY, Kawamura Y, MizokamiK, Sasaki J, Tsujinaka S, Maeda T, et al. Colorectal surgery in octogenarian patients – outcomes and predictors of morbidity. Int J Colorectal Dis 2009;24:185-9.
- [33] Modini C, Romagnoli F, De Milito R, Romeo V, Petroni R, La Torre F, et al. Octogenarians: an increasing challenge for acute care and colorectal surgeons. An outcomes analysis of emergency colorectal surgery in the elderly. Colorectal Dis 2012;14:312-8.
- [34] Leong QM, Aung MO, Ho CK, Sim R. Emergency colorectal resections in Asian octogenarians: factors impacting surgical outcome. SurgToday 2009;39:575-9.
- [35] Kllingback M, Barron P, Dent O. Elective resection and anastomosis for colorectal caner: a prospective audit of mortality and morbidity 1976-1998. Aust N Z J Surg 2008;72:689-98.
- [36] Ozturk E, Yilmazlar T. Factors affecting the mortality risk in elderly patients undergoing surgery. ANZ J Surg 2007;77:156-9.
- [37] Kotake K, Asano M, Ozawa H, Kobayashi H, Sugihara K. Tumour characteristics, treatment patterns and survival of patients aged 80 years or older with colorectal cancer. Colorectal Disease 2014;17:205-15.
- [38] Patel SS, Nelson R, Sanchez J, Lee W, Uyeno L, Garcia-Aguilar J, et al. Elderly patients with colon cancer have unique tumor characteristics and poor survival. Cancer 2013;119:739-47.
- [39] ASheikh A, Joel AS, Johnson MA, Vimalachandran D. Outcome of colorectal cancer resection in octogenarians. S Afr J Surg 2013;51:68-72.
- [40] Devon KM, Vergara-Fernandez O, Victor JC, McLeod RS. Colorectal cancer surgery in elderly patients: presentation, treatment, and outcomes. Dis Colon Rectum 2009;52:1272-7.