Yıl 2020, Cilt 6 , Sayı 1, Sayfalar 62 - 66 2020-01-04

Nephrotoxicity rates related to colistin and evaluation of risk factors

Ali ASAN [1] , Derya KARASU [2] , Cuma Bülent GÜL [3] , Gülsün AKINCIOĞLU [4] , Nizameddin KOCA [5] , Mustafa Özgür AKÇA [6] , Canan YILMAZ [7] , İsra KARADUMAN [8] , Şükran KÖSE [9]


Objectives: Colistimethate sodium (colistin) is the member of polymyxins, the cyclic structured cationic polypeptide antibiotics. The purpose of our study is to determine the patients’ nephrotoxicity rates and risk factors related to nephrotoxicity development that are under colistin treatment in the tertiary intensive care unit (ICU).

Methods: One-hundred colistin received patients files were reviewed retrospectively, who were in tertiary ICU in Bursa Yüksek Ihtisas Training and Research Hospital. Fifteen patients with the history of renal failurewere excluded from the study. The data before the first colistin treatment was taken into consideration for the patients received repetitive colistin treatment. RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) classification was used for the evaluation of nephrotoxicity.

Results: The patients mean age was 67.81 ± 16.56 years (range: 21-94) and 52.9% were male. Nephrotoxicity was determined in 35 (41.2%) patients. According to the RIFLE classification the nephrotoxicity rates were determined for risk, injury and deficiency were 24.7%, 10.6% and 5.9%, respectively. Nephrotoxicity was detectedin 9 (25.7%) out of 35 patients on the first day of the colistin treatment. Mortality rate was observed as 82.9% in patients with nephrotoxicity.

Conclusions: Colistin treatment is preferable for the treatment of multi drug resistant infections in intensive care unit. The patients,under certain circumstances, i.e., malignancy, using additional nephrotoxic agent and elder age must be closely monitored for the possible nephrotoxicity development. 

colistin, nephrotoxicity, RIFLE score
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Bölüm Original Article
Yazarlar

Orcid: 0000-0002-8856-7356
Yazar: Ali ASAN (Sorumlu Yazar)
Kurum: Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0003-1867-9018
Yazar: Derya KARASU
Kurum: Department of Anesthesiology and Reanimation, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0003-2467-9356
Yazar: Cuma Bülent GÜL
Kurum: Department of Nephrology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0001-8451-5201
Yazar: Gülsün AKINCIOĞLU
Kurum: Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Tepecik Training and Research Hospital, İzmir, Turkey
Ülke: Turkey


Orcid: 0000-0003-1457-4366
Yazar: Nizameddin KOCA
Kurum: Department of Internal Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0001-7988-0095
Yazar: Mustafa Özgür AKÇA
Kurum: Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0002-6626-3626
Yazar: Canan YILMAZ
Kurum: Department of Anesthesiology and Reanimation, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0003-2302-012X
Yazar: İsra KARADUMAN
Kurum: Department of Anesthesiology and Reanimation, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0002-4228-1213
Yazar: Şükran KÖSE
Kurum: Department of Internal Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 4 Ocak 2020

EndNote %0 The European Research Journal Nephrotoxicity rates related to colistin and evaluation of risk factors %A Ali ASAN , Derya KARASU , Cuma Bülent GÜL , Gülsün AKINCIOĞLU , Nizameddin KOCA , Mustafa Özgür AKÇA , Canan YILMAZ , İsra KARADUMAN , Şükran KÖSE %T Nephrotoxicity rates related to colistin and evaluation of risk factors %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 1 %R doi: 10.18621/eurj.459250 %U 10.18621/eurj.459250