Red cell distribution width and red cell distribution width to total serum calcium ratio as predictors of mortality in acute pancreatitis: a retrospective cohort study

Year 2020, Volume: 6 Issue: 2, 92 - 98, 04.03.2020

Cihan Bedel , Sefa Türkoğlu

https://doi.org/10.18621/eurj.465878

Cited By: 4

Abstract

Objectives:
We
investigated whether red cell
distribution width (RDW) and red cell distribution width to total serum calcium
(RDW-to-TSC) ratio were associated with mortality in patients with acute
pancreatitis (AP).

Methods: A
total of 170 patients who present emergency department  between January 2017 and June 2018 with a
diagnosis of AP were enrolled in this study. A comparison between survivor and nonsurvivor AP patients
was performed. Diagnosis of AP were defined according to the revised Atlanta
classification 2012. Variables evaluated included demographics, hospital
stay, laboratorial parameters and mortality.

Results: AP
related in-hospital mortality was 6.4%. Red cell distribution (RDW), white
blood cell (WBC), platelet, serum
glucose and RDW-to-TSC ratio were associated with AP mortality. RDW-to-TSC ratio had the
highest AUC (0.88; 95% CI, 0.756-1.0), followed by RDW, serum glucose, platelet and WBC (AUC = 0.801, 0.797, 0.743 and
0.687 respectively). A cut-off value of RDW-to-TSC
ratio >2.0, the highest sensitivity (91.9%), specificity (81.1%), PPV
(82.9%), and NPV (91.1%) were achieved for prediction of AP related in-hospital
mortality in approximately 86.5% of the cases (p < 0.001).

Conclusions: RDW
and TSC are  simple, inexpensive routine
serum parameters, provided in a complete blood count test and available at
admission. This study
showed that RDW > 16.6 and RDW-to-TSC > 2.0 were very good predictors for
AP mortality. 

Keywords

acute pancreatitis, mortality, red cell distribution width, serum calcium

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