Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia

Yıl 2015, Cilt: 1 Sayı: 3, 88 - 93, 04.11.2015

Nilay Duman Nilay Sen Korkmaz Zafer Erol

https://doi.org/10.18621/eurj.2015.1.3.88

Cited By: 1

Öz

Objectives. The literature does not include any comparative study on the eosinophil count in premalignant and malignant cutaneous squamous neoplasias. Our aim was to compare the tissue eosinophilic count in actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC). Methods. The study included 20 AK and 20 invasive SCC patients. Age, gender, and lesion location were retrospectively evaluated as clinical parameters. Histopathological parameters included density of inflammation score, lesion grade, and the lesion-associated eosinophil count per 10 high-power (40×) microscopic fields, all of which were compared between groups. Results. In all, 65% of the AK group had lesions with moderate inflammation, whereas 85% of the SCC group had lesions with dense inflammation (p=0.001). The mean eosinophil count in the SCC group was significantly higher than that in the AK group, independent of the density of inflammation (p=0.000). In addition, lesion grade was not associated with the eosinophil count in either group (AK group: p=0.601; SCC group: p=0.416). Conclusions. Cutaneous SCC lesions had higher eosinophil counts than AK lesions, indicating the role of the eosinophil count as a histopathological marker of stromal invasion.

Anahtar Kelimeler

Eosinophilia, actinic keratosis, squamous cell carcinoma, invasion

Kaynakça

• Jain M, Kasetty S, Sudheendra US, Tijare M, Khan S, Desai A. Assessment of tissue eosinophilia as a prognosticator in oral epithelial dysplasia and oral squamous cell carcinoma-an image analysis study. Patholog Res Int. 2014;2014:507512.
• Alrawi SJ, Tan D, Stoler DL, Dayton M, Anderson GR, Mojica P, et al. Tissue eosinophilic infiltration: a useful marker for assessing stromal invasion, survival and locoregional recurrence in head and neck squamous neoplasia. Cancer J. 2005 May-Jun;11(3):217-25.
• Ratushny V, Gober MD, Hick R, Ridky TW, Seykora JT. From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest. 2012 Feb;122(2):464-72.
• Cockerell CJ. Histopathology of incipient intraepidermal squamous cell carcinoma (“actinic keratosis”). J Am Acad Dermatol. 2000 Jan;42(1 Pt 2):11-7.
• Bhargava A, Saigal S, Chalishazar M. Histopathological grading systems in oral squamous cell carcinoma: a review. J Int Oral Health. 2010 Dec;2(4):1-10.
• Lowe D, Fletcher CD, Shaw MP, McKee PH. Eosinophil infiltration in keratoacanthoma and squamous cell carcinoma of the skin. Histopathology. 1984 Jul;8(4):619-25.
• Spiegel GW, Ashraf M, Brooks JJ. Eosinophils as a marker for invasion in cervical squamous neoplastic lesions. Int J Gynecol Pathol. 2002 Apr;21(2):117-24.
• Agarwal S, Wadhwa N, Gupta G. Eosinophils as a marker for invasion in cervical squamous neoplastic lesions. Int J Gynecol Pathol. 2003 Apr;22(2):213.
• Said M, Wiseman S, Yang J, Alrawi S, Douglas W, Cherey R, et al. Tissue eosinophilia: a morphologic marker for assessing stromal invasion in laryngeal squamous neoplasms. BMC Clin Pathol. 2005 Jan 7;5(1):1.
• Kapp DS, LiVolsi VA. Intense eosinophilic stromal infiltration incarcinoma of the uterine cervix: a clinicopathologic study of 14 cases. Gynecol Oncol. 1983 Aug;16(1):19-30.
• Lowe DG. Carcinoma of the cervix with massive eosinophilia. Br J Obstet Gynaecol. 1988 Apr;95(4):393-401.
• Joshi PS, Kaijkar MS. A histochemical study of tissue eosinophilia in oral squamous cell carcinoma using Congo red staining. Dent Res J (Isfahan). 2013 Nov;10(6):784-9.
• Pereira MC, Oliveira DT, Kowalski LP. The role of eosinophils and eosinophil cationic protein in oral cancer: a review. Arch Oral Biol. 2011 Apr;56(4):353-8.