The utilization of the large unstained cell (LUC) parameter in lymphoid, haematopoietic and related tissue’s malignant neoplasms

Year 2025, Volume: 11 Issue: 4, 732 - 740, 04.07.2025

Gamze Gök , Serpil Erdoğan , Erbay Asutay , Gülsen Yılmaz , Özcan Erel , Fatma Meriç Yılmaz

https://doi.org/10.18621/eurj.1625710

Abstract

Objectives: Large unstained cells (LUCs) are a differential count parameter reported by routine hematology analysis, and LUC percentages (LUC%) reflect active lymphocytes and peroxidase-negative cells. We aimed the evaluate the LUC% parameter in routine practice towards malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic, and related tissue.

Methods: LUC analysis was performed with Siemens ADVIA® 2120 Hematology System. Data were obtained from Ankara Bilkent City Hospital’s laboratory information system.

Results: A statistical difference in the LUC % data in the case of LUC % <4.5 and LUC % ≥4.5 among preliminary diagnoses was observed (P<0.001). According to the Kruskal-Wallis test, a statistical difference was observed between preliminary diagnosis and LUC % values (P<0.001). The One-way ANOVA test with Bonferroni correction was performed for post hoc multiple comparisons of the preliminary diagnosis among LUC%. LUC% was higher in Hodgkin Lymphoma patients than Myeloid leukaemia patients (P=0.002). LUC % was higher in the Lymphoid leukaemia patients than in the patients with Hodgkin lymphoma (P<0.001), Other and unspecified types of non-Hodgkin lymphoma (P<0.001), Multiple myeloma and malignant plasma cell neoplasms (P<0.001). LUC% was higher in patients with leukemia unspecified cell type than Hodgkin lymphoma (P<0.001), Follicular lymphoma (P<0.001), Non-follicular lymphoma (P<0.001), Mature T-Cell and Natural Killer Cell lymphomas (P<0.001), Other and unspecified types of non-Hodgkin lymphoma (P<0.001), Malignant immunoproliferative diseases (P<0.001), Multiple myeloma and malignant plasma cell neoplasms (P<0.001), Lymphoid leukaemia (P<0.001), Myeloid leukaemia (P<0.001), Other leukaemias of specified cell type patients (P<0.001).

Conclusions: The present study underscores the importance of LUC% in line with ICD-10 and may provide ideas for new research. Prospective studies including patient and control groups may be useful in assessing LUC%.

Keywords

Large unstained cells (LUCs) , Siemens ADVIA 2120 , complete blood cell count , ICD-10 , neoplasms

Ethical Statement

This study was approved by the Ankara City Hospital Clinical Research Ethics Committee No. 1 (Decision no. E1-20-481, date: 30.04.2020).

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