Peroxisome Proliferator-activated Receptor-alpha (PPARA) and – Gamma (PPARG) Polymorphisms as Risk Factors for Dyslipidemia and MetS in Turkish Adults

Filiz Güçlü Geyik; Evrim Kömürcü-bayrak; Günay Can; Nihan Erginel-ünaltuna

doi:10.26650/experimed.1382282

Research Article

Peroxisome Proliferator-activated Receptor-alpha (PPARA) and – Gamma (PPARG) Polymorphisms as Risk Factors for Dyslipidemia and MetS in Turkish Adults

Year 2023, , 281 - 289, 28.12.2023

Filiz Güçlü Geyik , Evrim Kömürcü-bayrak , Günay Can , Nihan Erginel-ünaltuna

https://doi.org/10.26650/experimed.1382282

Abstract

Objective: Dyslipidemia and metabolic syndrome (MetS) are complex diseases affected by environmental factors such as lifestyle and genetic predisposition. The genes encoding peroxisome proliferator-activated receptor-gamma (PPARG) and alpha (PPARA) are crucial in the development of dyslipidemia and MetS. We aimed to investigate the relation of these genes with dyslipidemia and MetS in the Turkish adult population.
Materials and Methods: The Turkish Adult Risk Factor (TARF-TEKHARF) cohort was randomly selected, and a cross-sectional analysis was performed. The PPARA rs1800206 C>G genotypes were determined in a sample of 339 unrelated Turkish adults by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and 12% polyacrylamide gel electrophoresis (PAGE) methods. The PPARG rs1801282 C>G genotypes were determined in a sample of 436 unrelated Turkish adults by a PCR-RFLP method.
Results: Both single nucleotide polymorphisms (SNPs) minor alleles were related to a risk of dyslipidemia. Logistic regression analysis showed a significantly increased risk for dyslipidemia in G allele carriers of rs1800206 C>G (Odds Ratio (OR)= 3.26; 95% CI= 1.16-9.12), and in G risk allele carriers of rs1801282 (OR= 1.85; 95% CI= 1.07-3.19), after adjustment for age, gender, lipid-lowering medication usage, physical activity and smoking status. Regarding MetS risk in the TARF study group, the G-allele of rs1800206 PPARA gene exhibited a significant OR of 3.75, after adjustment for gender, age, smoking status, and physical activity.
Conclusion: The G alleles of the studied SNPs in the PPARA and PPARG genes are related to increased dyslipidemia risk. Furthermore, The G allele of the PPARA gene is related to increased MetS risk.

Keywords

Dyslipidemia, metabolic syndrome, PPARA, PPARG and Turkish adults

Supporting Institution

This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK Project number: SBAG-3091)

Project Number

TUBITAK Project number: SBAG-3091

Thanks

Acknowledgements This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK Project number: SBAG-3091). We thank the Turkish Society of Cardiology and the pharmaceutical companies AstraZeneca, Pfizer and Sanofi-Aventis (Istanbul) that have financially supported the Turkish Adult Risk Factor study.

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