Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study

Year 2024, , 92 - 101, 26.08.2024

Nur Damla Korkmaz , Birsen Elibol , Seda Süsgün , Ceyhun Toruntay , Alişan Bayrakoğlu , Mazlum Yuzgulec , Zihni Elagoz , Ayşegül Yabacı Tak , Emrah Yücesan , Ferda İlgen Uslu , Gülsen Babacan Yıldız , Azize Esra Başar Gürsoy , Fahri Akbaş , Bilge Sümbül

https://doi.org/10.26650/experimed.1472096

Abstract

Objective: Neuroinflammation and blood-brain barrier (BBB) dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death. BBB integrity decline is evident in Alzheimer's Disease (AD), Parkinson's Disease (PD), Multiple Sclerosis (MS), and epilepsy.
Materials and Methods: We measured levels of lipopolysaccharide (LPS), the largest endotoxin, and brain-derived neurotrophic factor (BDNF) in patients' blood plasma and correlated them with biochemical parameters to identify biomarkers for these diseases.
Results: Significant associations were observed between LPS, C-reactive protein (CRP), BDNF, and lactate dehydrogenase (LDH) levels across conditions. LPS was positively correlated with CRP levels in epilepsy (r=0.753, p=0.002). Additionally, BDNF was negatively correlated with CRP in PD patients (r=-0.53, p=0.042). Moreover, a negative correlation was found between LPS and LDH in AD patients (r=-0.521, p=0.047).
Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.

Keywords

Brain-derived neurotrophic factor, lipopolysaccharide, neuroinflammation, neurological diseases, biomarker

Ethical Statement

The study was approved by the Bezmialem Vakif University Research Ethics Committee (07.06.2017, No:12/27; 05/07.2017, No:14/18; 10.07.2020, No:08/117; 10.03.2021, No:3/11) and informed consent was obtained from all participants. In addition, this study was conducted in accordance with the ethical principles described by the Declaration of Helsinki.

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