Antifosfolipid Sendromunda Doku Faktörü Düzeyi ve Doku Faktörü Promotor Bölge -603a/g Polimorfizminin Değerlendirilmesi

Year 2019, , 1 - 6, 30.04.2019

Resul Kahraman , Veysel Hancer Arzu Ergen Bedia Çakmakoğlu Reyhan Diz Küçükkaya

https://doi.org/10.26650/experimed.2019.19006

Abstract

Keywords

aPLA, antifosfolipid antikorlar, APS, antifosfolipid sendromu, TF, doku faktörü

Evaluation of Tissue Factor -603 A/G Promoter Gene Polymorphism in Thrombotic Processes in Patients with Antiphospholipid Syndrome

Abstract

DOI:
10.26650/experimed.2019.19006

Objective: Major clinical manifestations of
Antiphospholipid syndrome (APS) are trombosis and thrombosis related
complications. Tissue factor (TF) serves primary initiatory of the in vivo
coagulation. TF gene expression may be induced in endothelial cells to initiate
thrombus formation. In this study, we investigated the frequency of TF 603A/G
promoter gene polymorphism in patients with antiphospholipid syndrome (APS) and
its effects on TF expression and thrombotic events.

Materials and Methods: This study included
64 patients with APS (APS patient with thrombosis arterial and venous (n=38),
antiphospholipid antibody-positive patients without thrombosis (n=26) and 44
healthy controls (HCs). Plasma TF levels and antiphospholipid antibodies were
measured by ELISA method. Lupus anticoagulant was measured by activated partial
thromboplastin time and kaolin clotting time. TF-603 A/G polymorphism was
investigated by PCR method.

Results: Our results have showed that
patients with APS, TF levels were found in patients significantly higher than
the healthy control group (p: 0.006, p<0.001, respectively). Compared
between the two patient groups, TF level was significantly higher in the
patient with thrombosis group compared to the patient without thrombosis group
(p: 0.027).

Conclusion: In this study, we suggest that
thrombotic complications observed in patients with APS are associated with
increased TF expression.

Cite this article as: Kahraman R, Hançer V,
Ergen A, Çakmakoğlu B, Diz Küçükkaya R. Evaluation of tissue factor -603 A/G
promoter gene polymorphism in thrombotic processes in patients with
antiphospholipid syndrome. Experimed 2019; 9(1): 1-6.

Keywords

aPLA, antiphospholipid antibodies, APS, antiphospho­lipid syndrome, TF, tissue factor

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