Yara İyileşmesi ve Deneysel Yara Modelleri

Abstract

Yara iyileşmesi hücresel, biyokimyasal ve sistemik proseslerde travma ile başlayan bozulmanın yeni doku oluşumu ile normal haline döndürülmesidir. Akut yaralar belirli bir süre içerisinde dokunun normal anatomik ve işlevsel bütünlüğüne geri dönebildiği yaralar olup tedavisi nisbeten problemsizdir. Kronik yaralar ise akut yaraların aksine, genellikle altta yatan bir hastalık nedeniyle yara iyileşme süreçlerinin kesintiye uğraması sonucu anatomik ve işlevsel bütünlüğün sağlanamadığı yaralardır. Kronik yaralar gelişmiş ülkelerde nüfusun önemli bir bölümünü etkileyen, yaşam kalitesini düşüren önemli bir sağlık sorunu olmasının yanı sıra, yara tedavisi sağlık sistemlerine ciddi bir mali yük getirmektedir. Son yıllardaki teknolojik gelişmelerle birlikte, yara tedavisinde kullanılan ilaçlar ve tıbbi cihazlar bakımından önemli ilerlemeler kaydedilmiştir, ancak bu gelişmelere rağmen, yara iyileşme süreçlerindeki karmaşık yapı ve hasta çeşitliliği nedeniyle yara tedavisi alanındaki deneysel araştırmalar, hala önemini korumaktadır. Bu derlemede, yara iyileşmesi ve deneysel yara modellerine odaklanılarak temel kavramlar ve araştırmada kullanılan güncel uygulamalar ele alınmıştır. Cite this article as: Baktır G. Wound Repair and Experimental Wound Models. Experimed 2019; 9(3): 130-7.

Keywords

• Yara,yara iyileşmesi,deneysel yara modelleri

Wound Repair and Experimental Wound Models

Abstract

Wound healing is the restoration of distorted cellular, biochemical and systemic processes with trauma to normalization with new tissue formation. Acute wounds are wounds in which the tissue can return to normal anatomical and functional integrity over a period of time, and treatment is relatively problem-free. Chronic wounds, on the other hand, are wounds in which anatomic and functional integrity cannot be achieved as a result of disruption of wound healing processes due to an underlying disease. Chronic wounds are a major health problem that affects a significant proportion of the population and reduces the quality of life. Moreover, wound care creates a significant financial burden on health systems in developed countries. With the technological advances in recent years, significant progress has been made in terms of drugs and medical devices used in wound treatment, however, despite these developments, experimental research in the field of wound therapy remains important due to the complex structure in wound healing processes and patient diversity. In this review, basic concepts and current applications used in wound research are discussed focusing on wound healing process and experimental wound models. Cite this article as: Baktır G. Wound Repair and Experimental Wound Models. Experimed 2019; 9(3): 130-7.

Keywords

• Wound,wound repair,experimental wound models

References

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