Akut Miyokard Enfarktüsü Geçiren Genç Hastalarda Oksidatif Stres Belirteçleri ve Kardiyak Enzimlerle İlişkisi

Abstract

Amaç: Oksidatif stres ile akut miyokard infarktüsü (AMİ) arasındaki ilişki pek çok çalışma ile gösterilmiştir. Total antioksidan seviyesi (TAS), total oksidan seviyesi (TOS) ve oksidatif stres indeksi (OSI) oksidatif dengeyi yansıtır. Genç hastalarda AMİ'nin risk faktörleri, klinik özellikleri ve prognozu, yaşlı gruptan farklıdır. Bu çalışma TAS, TOS ve OSI'nin kantitatif ölçümü ile genç AMİ hastalarında 48 saat içerisindeki seyrini ve kardiyak belirteçlerle ilişkisini belirlemeyi amaçlamaktadır.

Gereç ve Yöntem: Bu prospektif, kontrollü çalışmaya 45 yaş ve al-tında AMİ tanısı almış 50 hasta ve kontrol grubu olarak 20 sağlıklı birey dahil edilmiştir. TOS ve TAS, venöz kan örneklerinden spektrofotometrik yöntemle ölçülmüştür. Oksidatif stres indeksi bu pa-rametreler üzerinden elde edilmiştir.

Bulgular: Toplam 50 hastanın kırkbeşi erkek ve ortalama yaş (36±6,8) idi. TOS ve OSI değerleri kontrol grubuna göre anlamlı olarak yüksek bulundu (p=0,002; p=0,005). TAS değerleri kontrol grubundan farklı bulunmadı (p=0,46). Sırasıyla CK 0. saat (s) ve TOS 0. s., CK-MB 0. s. ve TOS 0. s., CK 48. s. ve OSI 48. s., CK-MB 48. s. ve OSI 48. s. arasında anlamlı bir korelasyon olduğu bulundu (r=0,36, p=0,008; r=0,46, p=0,001; r=0,32, p=0,03; r=0,36, p<0,01).

Sonuç: Oksidatif stres AMİ'nin erken saatlerinde artmaktadır. TOS ve OSI değerleri, yalnızca belirli zaman dilimlerinde kardiyak belir-teçlerle ilişkilendirebilmekte ve genç AMİ hastalarında prognostik değerleri sınırlı olmaktadır. TAS, kardiyak belirteçlerle ilişkili bulunmamıştır.

Keywords

• Total antioksidan seviyesi
• total oksidan sevi-yesi
• oksidatif stres indeksi
• miyokard infarktüsü

Oxidative Stress Markers in Young Patients with Acute Myocardial Infarction and Their Correlation with Cardiac Enzymes

Abstract

Objective: The relationship between oxidative stress and acute myo-cardial infarction has been shown in studies. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) reflect the oxidative balance. The risk factors, clinical features, and prognosis of acute myocardial infarction (AMI) in young patients differ from older counterparts. This study aims to determine the oxidative stress in the young acute AMI patients and its' correlation with cardiac markers within 48 hours by the quantitative measurement of TAS, TOS, and OSI.

Material and Method: In this prospective, controlled study, we included 50 patients who were 45 years old or younger and di-agnosed with AMI, as well as 20 healthy individuals as the control group. TOS and TAS were measured from venous blood samples via the spectrophotometric method. The oxidative stress index was obtained from these parameters.

Results: Forty-five of totally 50 patients were male, and the mean age was (36±6.8). TOS and OSI values were found significantly higher than in the control group (p=0.002, p=0.005, respectively). TAS val-ues were found not to be different from the control group (p=0.46). A significant correlation was found between CK 0. hour (h.), and TOS 0. h., CK-MB 0. h., and TOS 0. h., CK 48. h. and OSI 48. h., CK-MB 48. h. and OSI 48. h., respectively (r=0.36, p=0.008), (r=0.46, p=0.001), (r=0.32, p=0.03), (r=0.36, p<0.01).

Conclusion: Oxidative stress increases in the early hours of AMI. The TOS and OSI values are correlated with cardiac markers at only some time points, and their prognostic values are limited in young AMI patients. TAS is not correlated with cardiac markers.

Keywords

• Total antioxidant status
• total oxidant status
• oxidative stress index
• myocardial infarction

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