Opticospinal Multiple Sclerosis Clinical Course and Immunological Parameters

Year 2018, Volume: 8 Issue: 2, 47 - 51, 12.11.2018

Özlem Mercan , Zekiye Ülger Cemile Handan Mısırlı Recai Türkoğlu

Abstract

DOI: 10.26650/experimed.2018.18002

Objectives: The clinical course of
opticospinal multiple sclerosis (OSMS) is different from that of classical
multiple sclerosis (MS) and exhibits a remarkable similarity with that of
neuromyelitis optica (NMO). This study aimed to define the immunological
parameters of OSMS to distinguish OSMS from classic MS and NMO and to highlight
the pathology of OSMS and treatment choice.

Material and Method: In total, 20 patients
with MS, 14 with OSMS, 18 with NMO, and 21 healthy controls were enrolled in
the study. Serum cytokine levels were measured using the multiple bead method,
and the results were compared with those obtained using the post hoc analysis
of variance and Tukey’s test.

Results: Interleukin (IL)-8 levels were
significantly lower in the MS and OSMS groups than in the NMO and control
groups (p<0.0001). IL-6 levels were found to be significantly lower in the
NMO and control groups than in the MS and OSMS groups (p=0.042). Tumor necrosis
factor alpha ( TNF-α) levels were significantly lower in the NMO and control
groups than in the MS and OSMS groups (p<0.0001).

Conclusion: The findings of our study
suggest that people with OSMS and NMO exhibit different levels of cytokines and
that Aqp-4-negative OSMS, which is not a spinal longitudinal disease, is not a
variant of NMO.

Keywords

Optic nerve, spinal cord, demyelinatic

Optikospinal Multipl Skleroz Klinik Seyir ve İmmünolojik Parametreler

Abstract

DOI: 10.26650/experimed.2018.18002

Amaç: Optikospinal multipl sklerozun (OSMS)
klinik seyrinin klasik multipl sklerozdan (MS) farklı olduğu bilinmekte,
nöromyelitis optika (NMO) ile de benzerliği dikkat çekmektedir. Biz bu
çalışmayla OSMS’i klasik MS ve NM’dan ayıracak immunolojik parametreler
tanımlayıp hastalığın seyri ve tedavi seçimi açısından fikir vermesini
amaçladık.

Gereç ve Yöntem: Çalışmaya 20 MS, 14 OSMS,
18 NMO ve 21 sağlıklı kontrol olgusu alındı. Serum sitokin düzeyleri çoklu
boncuk yöntemi ile ölçüldü. Sonuçlar 
ANOVA ve Tukey’in post hoc testi ile karşılaştırıldı.

Bulgular: IL-8 düzeyleri MS ve OSMS
gruplarında NMO ve sağlıklı kontrol grubuna göre anlamlı derecede düşük
saptandı (p<0,0001). IL-6 düzeyleri ise NMO ve sağlıklı kontrol gruplarında
MS ve OSMS grubundan anlamlı derecede düşüktü (p=0.042). Tümör nekrotizan
faktör alfa (TNF-α) düzeyine bakıldığında NMO ve sağlıklı kontrol gruplarının
MS ve OSMS gruplarından anlamlı derecede düşük olduğu görüldü (p<0,0001).

Sonuç: Çalışmamız OSMS ve NMO hastalarında
birbirinden farklı sitokin düzeylerinin olduğunu göstermiş ve özellikle spinal
longitüdinal lezyonu olmayan,  Aquaporin-4
(Aqp-4) negatif OSMS’nin bir NMO spektrum hastalığı varyantı olmadığını
destekleyen bulgular sunmuştur. 

Keywords

Optik sinir, spinal kord, demiyelinizan

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