Mezenkimal Kök Hücre Sinyal Yolakları ve Etkileşim Faktörleri

Yıl 2019, Cilt: 9 Sayı: 3, 120 - 129, 01.12.2019

Gülsemin Çiçek Selçuk Duman Tahsin Murad Aktan

Öz

Kök hücreler, farklı tip fonksiyonel hücrelere dönüşme potansiyeline sahip, kendi kendini yenileyebilen ve farklılaşmamış hücrelerdir. Bu hücreler, kökenleri temel alınarak iki ana tip olarak sınıflandırılabilir: Preimplante embriyonun iç hücre kitlesinden köken alan ve 3 germ yaprağını da yapılandırabilecek embriyonik kök hücreler ile farklı doku ve organlarda bulunan, en az bir tip fonksiyonel yapıya farklılaşabilme kapasitesine sahip erişkin kök hücreler. Bu her iki kök hücre tipi de çok farklı etkileşim faktörleri varlığında kendi sinyal yollarını kullanarak kendi özelliklerini ve kapasitelerini sunar. Bu kök hücrelerin özelliklerini ayrıntılı olarak bilmek, terapötik maddelere önemli katkı sağlayacaktır.

Cite this article as: Çiçek G, Duman S, Aktan TM. Mesenchymal Stem Cell Signaling Pathway and Interaction Factors. Experimed 2019; 9(3): 120-9.

Anahtar Kelimeler

Kök hücre, sinyal yolağı, etkileşim faktörleri

Mesenchymal Stem Cell Signaling Pathway and Interaction Factors

Öz

Stem cells are self-renewing and undifferentiated cells with potential to transform into different types of functional cells. These cells can be classified into two types based on their roots; embryonic stem cells that originate from the inner cell mass of preimplanted embryos and can structure the tree germinal layers and, mature stem cells that have the potential to differentiate into at least one type of functional structure. Both types of the stem cells present their own characteristics and capacities by using their own signal pathways in the presence of very different interaction factors. Knowing the characteristics of those stem cells in detail will importantly contribute to therapeutics.

Cite this article as: Çiçek G, Duman S, Aktan TM. Mesenchymal Stem Cell Signaling Pathway and Interaction Factors. Experimed 2019; 9(3): 120-9.

Anahtar Kelimeler

Stem cell, signal pathway, interaction factors

Kaynakça

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