Apelin Levels According to the Site of Involvement in Inflammatory Bowel Diseases
Year 2024,
Volume: 14 Issue: 2, 126 - 130, 26.08.2024
Ezgi Değerli
,
Selcan Cesur
,
Ahmet Yavuz
,
Mahmut Said Değerli
,
Zeynep Ermiş Karaali
Abstract
Objective: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), presents ongoing challenges in terms of diagnosis and management. With increasing treatment options, reliable markers for assessing treatment response have become crucial. This study explored the potential of apelin, a peptide hormone implicated in inflammation, as a biomarker for monitoring disease activity in patients with IBD undergoing colonoscopy.
Materials and Methods: The study included 91 patients who were followed up for IBD. Apelin levels were measured in serum, and the site of involvement was simultaneously examined by colonoscopy. Alternations of apelin levels depending on the location of involvement was also considered.
Results: Despite the widespread presence of apelin in the gastrointestinal system (GIS), our findings did not reveal significant differences in apelin levels among patients with varying colonoscopic involvement (p=0.73).
Conclusion: Although apelin has potential as a biomarker of gastrointestinal inflammation in IBD, its precise role and clinical applicability necessitate comprehensive studies involving larger patient populations. Future research on apelin and IBD could refine its utility in disease monitoring and enhance its diagnostic significance.
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Year 2024,
Volume: 14 Issue: 2, 126 - 130, 26.08.2024
Ezgi Değerli
,
Selcan Cesur
,
Ahmet Yavuz
,
Mahmut Said Değerli
,
Zeynep Ermiş Karaali
References
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- 2. Jarmakiewicz-Czaja S, Zielinska M, Sokal A, Filip R. Genetic and epigenetic etiology of ınflammatory bowel disease: an update. Genes (Basel) 2022; 13(12): 2388. google scholar
- 3. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life 2019; 12(2): 113-22. google scholar
- 4. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998; 251(2): 471-6. google scholar
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- 7. Susaki E, Wang G, Cao G, Wang HQ, Englander EW, Greeley GH Jr. Apelin cells in the rat stomach. Regul Pept 2005; 129(1-3): 37-41. google scholar
- 8. Wang G, Anini Y, Wei W, Qi X, OCarroll AM, Mochizuki T, et al. Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion. Endocrinology 2004; 145(3): 1342-8. google scholar
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- 10. Mosli MH, Zou G, Garg SK, Feagan SG, MacDonald JK, Chande N, et al. C-reactive protein, fecal calprotectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients: a systematic review and meta-analysis. Am J Gastroenterol 2015; 110(6): 802-20. google scholar
- 11. Sipponen T, Kolho KL. Fecal calprotectin in diagnosis and clinical assessment of inflammatory bowel disease. Scand J Gastroenterol 2015; 50(1): 74-80. google scholar
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- 14. Topuz M, Cosgun M, Akkuş O, Bulut A, Sen O, Topuz AN, et al. Effect of spironolactone on plasma Apelin-12 levels in patients with chronic systolic heart failure. Acta Cardiol Sin 2016; 32(6): 690-7. google scholar
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- 19. Ge Y, Li Y, Chen Q, et al. Adipokine apelin ameliorates chronic colitis in Il-10-/- mice by promoting intestinal lymphatic functions. Biochem Pharmacol 2018; 148: 202-12. google scholar
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