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Yıl 2023, Cilt: 48 Sayı: 2, 337 - 358, 01.08.2023
https://doi.org/10.55262/fabadeczacilik.1187441

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Interaction of Statins with Grapefruit Juice

Yıl 2023, Cilt: 48 Sayı: 2, 337 - 358, 01.08.2023
https://doi.org/10.55262/fabadeczacilik.1187441

Öz

Grapefruit juice, which discovered to interact with felodipine for the first time, is now known to interact with more that 80 drugs. Statins are among the drugs that interact with grapefruit juice. Grapefruit juice-statin interactions were first investigated in 1998 in human pharmacokinetic studies with lovastatin and simvastatin. The pharmacokinetic and pharmacodynamic basis of the interaction has been extensively investigated in studies. Flavonoids and furanocoumarins, the main components of grapefruit juice, have been reported to cause drug interactions. Furthermore, statin-grapefruit juice interactions occur mostly through inhibition of cytochrome-3A4 (CYP3A4), to a lesser extent through inhibition of P-glycoprotein (P-gp) and organic anion transporting polypeptides (OATPs). Changes in plasma drug levels as a result of interaction may increase the side-effect of statins or reduce their therapeutic efficacy. Therefore, patients using statins are generally advised to avoid grapefruit juice consumption.

Kaynakça

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  • Zolkiflee, N.F., Affandi, M.M., Majeed, A.B.A. (2017). Lovastatin: history, physicochemistry, pharmacokinetics and enhanced solubility. International Journal of Research in Pharmaceutical Sciences, 8(1), 90-102.
Toplam 95 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Derleme
Yazarlar

Müge Ateş 0000-0001-9533-5791

Selma Şahin 0000-0001-5736-5906

Yayımlanma Tarihi 1 Ağustos 2023
Gönderilme Tarihi 11 Ekim 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 48 Sayı: 2

Kaynak Göster

APA Ateş, M., & Şahin, S. (2023). Interaction of Statins with Grapefruit Juice. Fabad Eczacılık Bilimler Dergisi, 48(2), 337-358. https://doi.org/10.55262/fabadeczacilik.1187441